“…By tuning the laser wavelength to align with the absorption bands of target molecules, researchers can enhance Raman signals, achieving higher sensitivity and specificity for detecting disease-related biomolecules, such as amyloid-beta (Aβ) peptides in AD and other brain disorders. 44,56 RRS enhances Raman signals by matching the excitation energy of incident photons to the electronic transition energy of target molecules, increasing the efficiency of Raman scattering and enabling the selective detection of disease-specific biomolecules. By selectively enhancing Raman signals from specific molecular vibrations through laser tuning, RRS provides detailed structural information about proteins and other key biomolecules involved in NDs and brain tumors, offering insights into changes in protein conformation, aggregation, and interactions, hallmarks of many brain disorders.…”