Applications of Platelet-Rich Fibrin Matrix in Facial Plastic Surgery

Abstract

Platelet concentrates enjoyed some clinical popularity in facial plastic surgery several years ago. However, interest waned due to expense, amount of blood required, equipment, space, and staff needed, and lack of clinically significant benefit. A novel, simple method of preparing an autologous platelet derivative (Selphyl; Aesthetic Factors, Princeton, NJ) allows rapid and inexpensive generation of a platelet-rich fibrin matrix (PRFM) that can be used to enhance healing after facial procedures as well as to rejuvenate the face without tissue manipulation. PRFM provides autologous, natural, but concentrated platelet growth factor release and stimulation of surrounding tissue. This article describes its use for cosmetic facial applications.

Is there sufficient research data to use platelet-rich plasma in dermatology?

“…Although the optimal PRP platelet concentration is unclear, the current method by which PRP is prepared is reported to involve 300-700% enrichment, with high platelet concentrations. [1] Owing to these high concentrations of growth factors, PRP has been used successfully in periodontal therapy, maxillofacial surgery, orthopedics, and sports medicine and recently, PRP has attracted attention in the field of dermatology.…”

Advanced Lipotransfer Techniques

“…Princeton, New Jersey) to process 18 cc of peripheral blood. Recent studies have shown excellent results when autologous fat is combined with PRP in aesthetic plastic surgery (73,74,75). In order to increase the potential for autologous fat graft acceptance and retention we mix the harvested fat with the autologous PRP in a 4:1 ratio.…”

Periodontal regeneration of an intrabony osseous defect with combination of platelet rich fibrin and bovine derived demineralized bone matrix: A case report

“…The application of PRF in fields of plastic surgery 13 , oral and maxillofacial surgery 14 and implant surgery 15 has demonstrated successful and rapid results in terms of bone regeneration. The field of Periodontal therapy, although, has just begun to explore the vast benefits of PRF.…”