Applications of physiological bases of aging to forensic science

Zapico, Sara C.; Ubelaker, Douglas H.; Adserias‐Garriga, Joe

doi:10.1002/9781119482062.ch13

Cited by 4 publications

(2 citation statements)

References 124 publications

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“…Another similarly applied method has been developed using the sternal end of the fourth rib, likewise, the element can be compared to a set of standardized models to determine the age; the siding of the rib makes little difference to the results and a few other ribs can also be used. , Nevertheless, all of these methods are rendered completely ineffective if the remains are fragmented or are already heavily degraded. This has led to the emergence of molecular and chemical methods of biological ageing …”

Section: Introductionmentioning

confidence: 99%

Relative Protein Abundances and Biological Ageing in Whole Skeletal Elements

Johnston

Buckley

2020

J. Proteome Res.

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Establishing biological age is an integral part of forensic investigations, currently achieved through morphological methods with varying degrees of accuracy. Furthermore, biological ageing is much easier in juveniles than in adults, at which point traditional ageing methods struggle. Therefore, biomolecular approaches are considered of great interest, with several protein markers already recognized for their potential forensic significance. However, previous studies have typically relied on subsampling different parts of skeletal elements. Here, we attempt to evaluate the proteome of complete elements using a rat model. In the analysis of specimens spanning beyond adulthood (1 week to 1.5 years), we observed 729 unique proteins across 33 samples (three for each sex for each of the five (female) or six (male)), five of which represent newly identified proteins in relation to age estimation: vimentin, osteopontin, matrilin-1, apolipoprotein A-I, and prothrombin. Most of these follow the trend of decreasing abundance through age, with the exception of prothrombin that increases. We consider the combined use of these relative abundances, along with those of previously noted fetuin-A, biglycan, albumin, and chromogranin-A signatures, as being of potential value to the development of an age estimation tool worthy of further evaluation in forensic contexts.

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Section: Introductionmentioning

confidence: 99%

Relative Protein Abundances and Biological Ageing in Whole Skeletal Elements

Johnston

Buckley

2020

J. Proteome Res.

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“…It has turned out that, in addition to the detection of D-amino acids in the cell walls of prokaryotes, free D-amino acids are involved in normal metabolism and in the regulation of eukaryotic vital activity [8]. D-AspA has been found in mammalian hormone-producing cells [9] and human dental dentin [10]. It has also been established that it is not the natural biologically active L-isomer which is effective in the treatment of certain diseases, but its synthetic D-antipode [11,12].…”

Section: Introductionmentioning

confidence: 99%

Features of L-Menthol Crystallization in Optically Active Medium Based on L- and D-Asparaginate Chitosan

Shipovskaya

Gegel

Shipenok

2023

J-BPE

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The phase separation kinetics of an ethanolic L-menthol solution in an aqueous solution of optically and biologically active chitosan L-and D-aspartate was studied. It has been established that this process proceeds according to the extraction crystallization mechanism and combines two types of phase separation, namely: liquid-liquid and liquid-crystal. The effect of aspartic acid stereoisomer, chitosan molecular weight, and polymer: acid ratio on the optical, structural-morphological, and dimensional characteristics of dispersed phase droplets at the initial stage of phase separation and crystal aggregates of the L-menthol condensed phase at the final stage was assessed. In the chitosan D-aspartate medium, as well as with an increase in the concentration of components in the optically active medium and the molecular weight of the polymer, the rate of phase separation, the size of droplets and particles increase. It has been suggested that the system under study is promising for encapsulating hydrophobic drugs, creating chirooptic waveguides, and sensors for biomedical purposes, as well as developing new methods for studying the fundamental principles of phase separation in intracellular regulation of membraneless organelles and subcellular organization of biosystems, including under stress conditions of a living organism underlying the development of new pharmaceuticals to treat rare and currently incurable diseases.

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Forensic Anthropology

Ubelaker¹

2023

A Companion to Biological Anthropology

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Applications of physiological bases of aging to forensic science

Cited by 4 publications

References 124 publications

Relative Protein Abundances and Biological Ageing in Whole Skeletal Elements

Relative Protein Abundances and Biological Ageing in Whole Skeletal Elements

Features of L-Menthol Crystallization in Optically Active Medium Based on L- and D-Asparaginate Chitosan

Forensic Anthropology

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