Applications of Optically Controlled Gold Nanostructures in Biomedical Engineering

Phummirat, Pisrut; Mann, Nicholas H.; Preece, Daryl

doi:10.3389/fbioe.2020.602021

Cited by 7 publications

(5 citation statements)

References 79 publications

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“…The maximum weight observed was 4.3 ± 0.3 mg for the 10% tablets with 8 nM AuNPs. The maximum density was 0.247 ± 0.0.039 g/cm 3 for the 6% dextran tablets with 8 nM AuNPs. The maximum opacity was 4.009 ± 0.107 for the 6% dextran tablets with 8 nM AuNPs.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Gold Tablets: Gold Nanoparticles Encapsulated into Dextran Tablets and Their pH-Responsive Behavior as an Easy-to-Use Platform for Multipurpose Applications

2022

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Many applications using gold nanoparticles (AuNPs) require (i) their functionalization with a biopolymer to increase their stability and (ii) their transformation into an easy-to-handle material, which provide them with specific properties. In this research, a portable tablet platform is presented based on dextran-encapsulated gold nanoparticles (AuNPs-dTab) by a ligand exchange reaction between citrate-capped gold nanoparticles (AuNPs-Cit) and dextran. These newly fabricated tablets were characterized utilizing ultraviolet–visible spectroscopy (UV–vis), Fourier transform infrared spectroscopy–attenuated total reflectance (FTIR–ATR), transmission electron microscopy (TEM), dynamic light scattering (DLS), X-ray diffraction spectroscopy (XRD), differential scanning calorimetry (DSC), and atomic force microscopy (AFM) techniques. The results showed that dextran-capped gold nanoparticles in a tablet platform (AuNPs-dTab) were well-dispersed and highly stable for at least a year at room temperature. In addition to particle and surface characterization of AuNPs-dTab, the tablet morphology in terms of thickness, diameter, density, and opacity was also measured using 6 and 10% dextran with 2, 4 and 8 nM AuNPs-Cit. We further investigated the pH-responsive behavior of AuNPs-dTab in the presence and absence of sodium chloride. Results showed that neutral and alkaline environments were suitable to render AuNPs dispersed in a tablet, while an acidic condition controls the aggregation rate of AuNPs as confirmed by concentration-dependent aggregation phenomena. Besides the easy fabrication, these tablets were portable and low-cost (approx. 1.22 CAD per 100 tablets of a 100 μL solution of dextran-capped gold nanoparticles (AuNPs-dSol)). The biocompatible nature of dextran along with the acidic medium trigger nature of AuNPs makes our proposed tablet a potential candidate for cancer therapy due to the acidic surrounding of tumor tissues as compared to normal cells. Also, our proposed tablet approach paves the way for the fabrication of portable and easy-to-use optical sensors based on the AuNPs embedded in a natural polymeric architecture that would serve as a colorimetric recognition indicator for detecting analytes of interest.

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Section: ■ Results and Discussionmentioning

confidence: 99%

“…Gold nanoparticles (AuNPs) have diverse applications in the area of heterogeneous catalysis, food sciences, biomedical engineering, − drug delivery, , biosensing − bioimaging, and many more. These nanoparticles have shown remarkable chemical, biological, optical, thermal, and electronic characteristics.…”

Section: Introductionmentioning

confidence: 99%

Gold Tablets: Gold Nanoparticles Encapsulated into Dextran Tablets and Their pH-Responsive Behavior as an Easy-to-Use Platform for Multipurpose Applications

2022

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“…The greatly enhanced signal-enabled SERS can detect an analyte with a lower concentration, even down to molecule level [13,14]. SERS could provide unique fingerprint spectrum information of the target; it is widely used in many fields such as pharmacology [15,16], food safety [17,18], environmental monitoring [19], and bioengineering [20]. The preparation of appropriate SERS substrates is an important prerequisite for application [21,22].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Application of Ag@SiO2/Au Core–Shell SERS Composite in Detecting Cu2+ in Water Environment

Zhang,

Meng,

Kalyinur

et al. 2024

Molecules

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A sensitive and simple method for detecting Cu2+ in the water source was proposed by using surface-enhanced Raman scattering spectroscopy (SERS) based on the Ag@SiO2/Au core–shell composite. The Ag@SiO2 SERS tag was synthesized by a simple approach, in which Ag nanoparticles were first embedded with Raman reporter PATP and next coated with a SiO2 shell. The Ag@SiO2 nanoparticles had strong stability even in a high-concentration salty solution, and there were no changes to their properties and appearance within one month. The Ag@SiO2/Au composite was fabricated through a controllable self-assemble process. L-cysteine was decorated on the surface of a functionalized Ag@SiO2/Au composite, as the amino and carboxyl groups of it can form coordinate covalent bond with Cu2+, which shows that the Ag@SiO2/Au composite labelled with L-cysteine has excellent performance for the detection of Cu2+ in aqueous media. In this study, the SERS detection of Cu2+ was carried out using Ag@SiO2 nanoparticles, and the limit of detection (LOD) as low as 0.1 mg/L was achieved.

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“…Furthermore, the gold nanoparticles have been used to enhance bio-optical imaging, and to improve its resolution, sensitivity, and penetration depth [ 55 ]. Because of the LSPR in the visible or near-infrared region, nanoparticles can play crucial roles in optical tweezers by enhancing the gradient force if the trapping laser is tuned to the long-wavelength side [ 56 ].…”

Section: Introductionmentioning

confidence: 99%

Optical Force and Torque on a Graphene-Coated Gold Nanosphere by a Vector Bessel Beam

Yan

Ling

et al. 2022

Micromachines

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In the framework of the generalized Lorenz–Mie theory (GLMT), the optical force and torque on a graphene-coated gold nanosphere by a vector Bessel beam are investigated. The core of the particle is gold, whose dielectric function is given by the Drude–Sommerfeld model, and the coating is multilayer graphene with layer number N, whose dielectric function is described by the Lorentz–Drude model. The axial optical force Fz and torque Tz are numerically analyzed, and the effects of the layer number N, wavelength λ, and beam parameters (half-cone angle α0, polarization, and order l) are mainly discussed. Numerical results show that the optical force and torque peaks can be adjusted by increasing the thickness of the graphene coating, and can not be adjusted by changing α0 and l. However, α0 and l can change the magnitude of the optical force and torque. The numerical results have potential applications involving the trapped graphene-coated gold nanosphere.

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Applications of Optically Controlled Gold Nanostructures in Biomedical Engineering

Cited by 7 publications

References 79 publications

Gold Tablets: Gold Nanoparticles Encapsulated into Dextran Tablets and Their pH-Responsive Behavior as an Easy-to-Use Platform for Multipurpose Applications

Gold Tablets: Gold Nanoparticles Encapsulated into Dextran Tablets and Their pH-Responsive Behavior as an Easy-to-Use Platform for Multipurpose Applications

Fabrication and Application of Ag@SiO2/Au Core–Shell SERS Composite in Detecting Cu2+ in Water Environment

Optical Force and Torque on a Graphene-Coated Gold Nanosphere by a Vector Bessel Beam

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