Applications of Neuromodulation in Pain Management

Knotková, Helena; Greenberg, Aaron; Soto, Eliezer; Cruciani, Ricardo A.

doi:10.1007/978-1-4939-1408-1_15

Cited by 3 publications

(3 citation statements)

References 257 publications

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“…Neuromodulation is promising because it can establish causal relationships between a brain region and particular behavioral functions (Knotkova & Rasche, 2014; S. H. Lee & Dan, 2012). Neuromodulation techniques such as optogenetics, transcranial magnetic stimulation (TMS), and electrical brain stimulation (EBS) allow researchers to transiently alter processing in a region and to determine the effects of this modulation on task performance (Suthana & Fried, 2014; Knotkova & Rasche, 2014). Showing that a cognitive process is transiently altered when a particular region is specifically stimulated demonstrates a causal link between the two (Suthana & Fried, 2014).…”

Section: Introductionmentioning

confidence: 99%

Electrical stimulation in hippocampus and entorhinal cortex impairs spatial and temporal memory

Goyal

Miller

Watrous

et al. 2017

Preprint

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The medial temporal lobe (MTL) is widely implicated in supporting episodic memory and navigation, but its precise functional role in organizing memory across time and space remains elusive. Here we examine the specific cognitive processes implemented by MTL structures (hippocampus and entorhinal cortex) to organize memory by using electrical brain stimulation, leveraging its ability to establish causal links between brain regions and features of behavior. We studied neurosurgical patients of both sexes who performed spatial-navigation and verbal-episodic memory tasks while brain stimulation was applied in various regions during learning. During the verbal memory task, stimulation in the MTL disrupted the temporal organization of encoded memories such that items learned with stimulation tended to be recalled in a more randomized order. During the spatial task, MTL stimulation impaired subjects’ abilities to remember items located far away from boundaries. These stimulation effects were specific to the MTL. Our findings thus provide the first causal demonstration in humans of the specific memory processes that are performed by the MTL to encode when and where events occurred.Significance StatementNumerous studies have implicated the medial temporal lobe (MTL) in encoding spatial and temporal memories, but they have not been able to causally demonstrate the nature of the cognitive processes by which this occurs in real-time. Electrical brain stimulation is able to demonstrate causal links between a brain region and a given function with high temporal precision. By examining behavior in a memory task as subjects received MTL stimulation, we provide the first causal evidence demonstrating the role of the MTL in organizing the spatial and temporal aspects of episodic memory.

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Section: Introductionmentioning

confidence: 99%

Electrical stimulation in hippocampus and entorhinal cortex impairs spatial and temporal memory

Goyal

Miller

Watrous

et al. 2017

Preprint

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“…At the end of each session, participants were evaluated by a Visual Analog Scale (VAS) [81] to report their subjective sensation. For the pre-tACS and post-tACS sessions, a VAS of fatigue evaluation was performed.…”

Section: Visual Analog Scalementioning

confidence: 99%

tACS facilitates flickering driving by boosting steady-state visual evoked potentials

Liu¹,

Yan²,

Chen³

et al. 2021

J. Neural Eng.

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Objective. There has become of increasing interest in transcranial alternating current stimulation (tACS) since its inception nearly a decade ago. tACS in modulating brain state is an active area of research and has been demonstrated effective in various neuropsychological and clinical domains. In the visual domain, much effort has been dedicated to brain rhythms and rhythmic stimulation, i.e. tACS. However, less is known about the interplay between the rhythmic stimulation and visual stimulation. Approach. Here, we used steady-state visual evoked potential (SSVEP), induced by flickering driving as a widely used technique for frequency-tagging, to investigate the aftereffect of tACS in healthy human subjects. Seven blocks of 64-channel electroencephalogram were recorded before and after the administration of 20min 10Hz tACS, while subjects performed several blocks of SSVEP tasks. We characterized the physiological properties of tACS aftereffect by comparing and validating the temporal, spatial, spatiotemporal and signal-to-noise ratio (SNR) patterns between and within blocks in real tACS and sham tACS. Main results. Our result revealed that tACS boosted the 10Hz SSVEP significantly. Besides, the aftereffect on SSVEP was mitigated with time and lasted up to 5 min. Significance. Our results demonstrate the feasibility of facilitating the flickering driving by external rhythmic stimulation and open a new possibility to alter the brain state in a direction by noninvasive transcranial brain stimulation.

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“…tDCS stimulation of the motor cortex using a montage with electrodes placed on the surface of the head over the area of motor cortex and contralateral supraorbital region (M1‐SO montage) has been frequently used in both research and clinical settings, not only for modulation of motor function , but also when aiming for pain relief , or for modulation of sleep characteristics . To date, the M1 electrode position in the M1‐SO montage can be determined using one of the following methods: 1) direct determination of the “hot spot” via evaluation of motor evoked potentials (MEPs) induced by the transcranial magnetic stimulation (TMS) of the motor area, with or without support by neuronavigational systems ; or 2) using the electrode position measurements delineated by the International 10–20 EEG system (Fig.…”

Section: Introductionmentioning

confidence: 99%

Automatic M1-SO Montage Headgear for Transcranial Direct Current Stimulation (TDCS) Suitable for Home and High-Throughput In-Clinic Applications

Knotková

Riggs²,

Berisha

et al. 2019

Neuromodulation: Technology at the Neural Interface

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Applications of Neuromodulation in Pain Management

Cited by 3 publications

References 257 publications

Electrical stimulation in hippocampus and entorhinal cortex impairs spatial and temporal memory

Electrical stimulation in hippocampus and entorhinal cortex impairs spatial and temporal memory

tACS facilitates flickering driving by boosting steady-state visual evoked potentials

Automatic M1-SO Montage Headgear for Transcranial Direct Current Stimulation (TDCS) Suitable for Home and High-Throughput In-Clinic Applications

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