Applications of nanotechnology in medical field: a brief review

Haleem, Abid; Javaid, Mohd; Singh, Ravi Pratap; Rab, Shanay; Suman, Rajiv

doi:10.1016/j.glohj.2023.02.008

Cited by 183 publications

(70 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the last few years, nanomedicine has emerged as a hot topic in cancer therapeutics for pharmacokinetics improvement and side-effects reduction. 137,138 Nanodrugs are usually biocompatible, non-immunogenic and non-toxic, and can deliver poorly soluble cargos to the tumor site in a more effective manner. Also, size, shape and surface can be easily tailored to modulate the desired biological response.…”

Section: Oxaliplatin-based Pt(iv) Prodrugsmentioning

confidence: 99%

Pt(iv) anticancer prodrugs bearing an oxaliplatin scaffold: what do we know about their bioactivity?

Lopez-Sanchez,

Bertrand

2024

Inorg. Chem. Front.

View full text Add to dashboard Cite

show abstract

Section: Oxaliplatin-based Pt(iv) Prodrugsmentioning

confidence: 99%

Pt(iv) anticancer prodrugs bearing an oxaliplatin scaffold: what do we know about their bioactivity?

Lopez-Sanchez,

Bertrand

2024

Inorg. Chem. Front.

View full text Add to dashboard Cite

show abstract

“…158 The substantial research in nanomedicine has transformed the field of drug discovery to a new level with significant healthcare implications. 159 To analyze the clinical success rate of nanomedicines in the global market, we conducted an analytical evaluation by gathering the number of relevant publications, clinical trial reports, and FDA approval face sheets. 160−162 These reports included not only preliminary investigation but also proof of concepts, novel nanotechnology methodologies, and clinical trial outputs on nanomedicine-based drug discovery.…”

Section: Clinical Success Of Nanomedicines and Phytonanomedicines In ...mentioning

confidence: 99%

“…The growing interest in application of nanotechnology in cancer is largely attributable to its unique features for drug delivery, as well as the therapeutic nature of some nanomaterials themselves . The substantial research in nanomedicine has transformed the field of drug discovery to a new level with significant healthcare implications . To analyze the clinical success rate of nanomedicines in the global market, we conducted an analytical evaluation by gathering the number of relevant publications, clinical trial reports, and FDA approval face sheets. − These reports included not only preliminary investigation but also proof of concepts, novel nanotechnology methodologies, and clinical trial outputs on nanomedicine-based drug discovery. − Aside from literature, there are 608 cancer-related clinical trials available as of 2022 according to ClinicalTrials.gov .…”

Section: Clinical Success Of Nanomedicines and Phytonanomedicines In ...mentioning

confidence: 99%

Phytochemical-Based Nanomedicine for Targeting Tumor Microenvironment and Inhibiting Cancer Chemoresistance: Recent Advances and Pharmacological Insights

Sa,

Mohapatra,

Swain

et al. 2023

Mol. Pharmaceutics

View full text Add to dashboard Cite

Cancer remains the leading cause of death and rapidly evolving disease worldwide. The understanding of disease pathophysiology has improved through advanced research investigation, and several therapeutic strategies are being used for better cancer treatment. However, the increase in cancer relapse and metastatic-related deaths indicate that available therapies and clinically approved chemotherapy drugs are not sufficient to combat cancer. Further, the constant crosstalk between tumor cells and the tumor microenvironment (TME) is crucial for the development, progression, metastasis, and therapeutic response to tumors. In this regard, phytochemicals with multimodal targeting abilities can be used as an alternative to current cancer therapy by inhibiting cancer survival pathways or modulating TME. However, due to their poor pharmacokinetics and low bioavailability, the success of phytochemicals in clinical trials is limited. Therefore, developing phytochemical-based nanomedicine or phytonanomedicine can improve the pharmacokinetic profile of these phytochemicals. Herein, the molecular characteristics and pharmacological insights of the proposed phytonanomedicine in cancer therapy targeting tumor tissue and altering the characteristics of cancer stem cells, chemoresistance, TME, and cancer immunity are well discussed. Further, we have highlighted the clinical perspective and challenges of phytonanomedicine in filling the gap in potential cancer therapeutics using various nanoplatforms. Overall, we have discussed how clinical success and pharmacological insights could make it more beneficial to boost the concept of nanomedicine in the academic and pharmaceutical fields to counter cancer metastases and drug resistance.

show abstract

“…Nanotechnology is an interdisciplinary field that encompasses the integration of several scientific disciplines, including natural sciences, mathematics, computer science, and materials science. It focuses on the study and manipulation of physical matter at the nanoscale, which corresponds to dimensions on the order of nanometers . The remarkable capabilities of constructed submicrometer structures, which have dimensions similar to those of biological molecules, have been acknowledged since the 1950s.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Acharya,

Behera,

Behera

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Over the past decade, nanotechnology has seen extensive integration into biomedical applications, playing a crucial role in biodetection, drug delivery, and diagnostic imaging. This is especially important in reproductive health care, which has become an emerging and significant area of research. Global concerns have intensified around disorders such as infertility, endometriosis, ectopic pregnancy, erectile dysfunction, benign prostate hyperplasia, sexually transmitted infections, and reproductive cancers. Nanotechnology presents promising solutions to address these concerns by introducing innovative tools and techniques, facilitating early detection, targeted drug delivery, and improved imaging capabilities. Through the utilization of nanoscale materials and devices, researchers can craft treatments that are not only more precise but also more effective, significantly enhancing outcomes in reproductive healthcare. Looking forward, the future of nanotechnology in reproductive medicine holds immense potential for reshaping diagnostics, personalized therapies, and fertility preservation. The utilization of nanotechnology-driven drug delivery systems is anticipated to elevate treatment effectiveness, minimize side effects, and offer patients therapies that are not only more precise but also more efficient. This review aims to delve into the various types, properties, and preparation techniques of nanocarriers specifically designed for drug delivery in the context of reproductive disorders, shedding light on the current landscape and potential future directions in this dynamic field.

show abstract

Applications of nanotechnology in medical field: a brief review

Cited by 183 publications

References 76 publications

Pt(iv) anticancer prodrugs bearing an oxaliplatin scaffold: what do we know about their bioactivity?

Pt(iv) anticancer prodrugs bearing an oxaliplatin scaffold: what do we know about their bioactivity?

Phytochemical-Based Nanomedicine for Targeting Tumor Microenvironment and Inhibiting Cancer Chemoresistance: Recent Advances and Pharmacological Insights

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Contact Info

Product

Resources

About