Applications of Nanotechnology in Dermatology

Napagoda, Mayuri; Wijayaratne, Weerasinghe Mudiyanselage Dilip Gaya Bandara; Witharana, Sanjeeva

doi:10.1007/978-981-19-8050-3_6

Cited by 2 publications

(1 citation statement)

References 125 publications

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“…The unrivalled surface energy of noble MNPs promotes the generation of new superb physical, chemical, and biological properties such as small particle sizes, light susceptibility, tailored morphology and surface interactions, chemical stability, and biological compatibility [ 14 , 15 ]. Among noble MNPs, silver nanoparticles (AgNPs) surpassed all due to their tunable surface engineering, potent biological activity, multiple inhibition mechanisms, and facile methods of synthesis [ 16 , 17 , 18 , 19 ]. However, some demerits concerning the antibacterial activity of AgNPs were encountered, such as the possibility of particle agglomeration, elevated cost, developed AMR to AgNPs, and their toxicological effects at high concentrations [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Docking Study of Novel Thioureidophosphonate-Incorporated Silver Nanocomposites as Potent Antibacterial Agents

et al. 2023

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Newly synthesized mono- and bis-thioureidophosphonate (MTP and BTP) analogues in eco-friendly conditions were employed as reducing/capping cores for 100, 500, and 1000 mg L−1 of silver nitrate. The physicochemical properties of silver nanocomposites (MTP(BTP)/Ag NCs) were fully elucidated using spectroscopic and microscopic tools. The antibacterial activity of the nanocomposites was screened against six multidrug-resistant pathogenic strains, comparable to ampicillin and ciprofloxacin commercial drugs. The antibacterial performance of BTP was more substantial than MTP, notably with the best minimum inhibitory concentration (MIC) of 0.0781 mg/mL towards Bacillus subtilis, Salmonella typhi, and Pseudomonas aeruginosa. Among all, BTP provided the clearest zone of inhibition (ZOI) of 35 ± 1.00 mm against Salmonella typhi. After the dispersion of silver nanoparticles (AgNPs), MTP/Ag NCs offered dose-dependently distinct advantages over the same nanoparticle with BTP; a more noteworthy decline by 4098 × MIC to 0.1525 × 10−3 mg/mL was recorded for MTP/Ag-1000 against Pseudomonas aeruginosa over BTP/Ag-1000. Towards methicillin-resistant Staphylococcus aureus (MRSA), the as-prepared MTP(BTP)/Ag-1000 displayed superior bactericidal ability in 8 h. Because of the anionic surface of MTP(BTP)/Ag-1000, they could effectively resist MRSA (ATCC-43300) attachment, achieving higher antifouling rates of 42.2 and 34.4% at most optimum dose (5 mg/mL), respectively. The tunable surface work function between MTP and AgNPs promoted the antibiofilm activity of MTP/Ag-1000 by 1.7 fold over BTP/Ag-1000. Lastly, the molecular docking studies affirmed the eminent binding affinity of BTP over MTP—besides the improved binding energy of MTP/Ag NC by 37.8%—towards B. subtilis-2FQT protein. Overall, this study indicates the immense potential of TP/Ag NCs as promising nanoscale antibacterial candidates.

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