Applications of nanostructured Pt-Au hybrid film for the simultaneous determination of catecholamines in the presence of ascorbic acid

Thiagarajan, S.; Chen, Shen‐Ming

doi:10.1007/s10008-008-0582-7

Cited by 23 publications

(8 citation statements)

References 36 publications

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“…They are, the nano-Au self assembled GCE for selective determination of epinephrine in the presence of ascorbic acid [16], nanostructured Pt-Au hybrid film for simultaneous determination of catecholamines in the presence of ascorbic acid [17], DNA combined gold nanoparticle multi layer films for selective determination of norepinephrine in presence of AA [18], boron-doped diamond electrode modified with gold nanoparticles/polyelectrolyte-coated polystyrene colloids [19], nano-Au self-assembly on GCE [20], and ferrocene encapsulated Pd-linked ormosil based biosensor for the dopamine detection process [21], respectively.…”

Section: Introductionmentioning

confidence: 99%

Palladium nanoparticles modified electrode for the selective detection of catecholamine neurotransmitters in presence of ascorbic acid

Thiagarajan

Yang

Chen

2009

Bioelectrochemistry

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Section: Introductionmentioning

confidence: 99%

Palladium nanoparticles modified electrode for the selective detection of catecholamine neurotransmitters in presence of ascorbic acid

Thiagarajan

Yang

Chen

2009

Bioelectrochemistry

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“…The linear range of response and limit of detection were analyzed in comparison to electrochemical sensors to adrenaline reported in the literature (Table 1). [39][40][41][42][43][44][45][46][47][48][49][50][51] As can be seen, the BEDT-TTF/DNA/TiO 2 /ITO photoelectroanalytical sensor shows a linear range of response of four orders of magnitude and a limit of detection of 1 nmol L -1 , which were as good as the best electrochemical sensors to adrenaline. The precision of measurements using the BEDT-TTF/DNA/TiO 2 /ITO photoelectroanalytical sensor was investigated from intra-day and inter-day repeatability studies.…”

Section: Optimization Of the Bedt-ttf/dna/tio 2 Photoelectroanalyticamentioning

confidence: 68%

Photoelectroanalytical Detection of Adrenaline Based on DNA and TiO2 Nanoparticles Sensitized with Bis(ethylenedithio)tetrathiafulvalene Exploiting LED Light

Santos¹,

Neto²,

Macena³

et al. 2017

J. Braz. Chem. Soc.

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In this study, a photoelectroanalytical sensor for determination of adrenaline based on deoxyribonucleic acid (DNA) and anatase titanium dioxide (TiO 2 ) nanoparticles sensitized with bis(ethylenedithio)tetrathiafulvalene (BEDT-TTF) was developed, which we henceforward call BEDT-TTF/DNA/TiO 2 /ITO. The photoelectroanalytical sensor showed high photocurrent to adrenaline under visible light emitting diode (LED) light irradiation in comparison to each component of the composite material. Under optimized conditions, the BEDT-TTF/DNA/TiO 2 /ITO sensor shows a linear response range from 10 nmol L -1 up to 100 µmol L -1 with a sensitivity of 8.1 nA L µmol -1 and limit of detection of 1 nmol L -1 for the detection of adrenaline. The photoelectrochemical sensor showed high photocurrent to adrenaline in comparison to photocurrent response to ascorbic acid and uric acid. The BEDT-TTF/DNA/TiO 2 /ITO photoelectrochemical sensor was successfully applied to urine samples, with recovery values between 96 and 106%. Keywords: adrenaline, photoelectrochemical sensor, visible LED light, deoxyribonucleic acid IntroductionAdrenaline, also known as epinephrine, is one of the most important message transfer compound in the mammalian central nervous system, which exist as an organic cation in the nervous tissue and the biological body fluid. 1 The level of adrenaline in the body affects a series of actions of the nervous system including the regulation of blood pressure, heart rate, lipolysis, immune response and glycogen metabolism. 2 In addition, adrenaline has been advocated during early cardiopulmonary resuscitation, early defibrillation and early advanced care in cardiac arrest for decades. 3 Therefore, the quantification of adrenaline in biological samples is of high interest nowadays. Urine represents one of the most easily attainable and, consequently, very common samples in adrenaline clinical analysis and diagnostics. The levels of adrenaline in biological fluids such as urine depends on the age and condition of the patient. 4 For healthy people, for example, the physiological concentration of adrenaline found in urine samples are in nanomolar level (22-109 nmol L -1 ). 5A number of analytical methodologies have been proposed for determination of adrenaline such as fluorimetric, 6 spectrophotometric, 7 enzymatic radioimmunoassay, 8 gas chromatography, 9 high performance liquid chromatography, 10 capillary electrophoresis 11 and electrochemical methods. [12][13][14][15] Despite the high number of analytical methods for adrenaline determination, most of them suffer from some disadvantages such as high cost, long analysis time, extensive sample pretreatment based on derivatization, extraction and purification as well as demands for highly trained users. The fluorometric and radioenzymatic assays are presently the most widely used techniques for the estimation of plasma, urine and tissue adrenaline. The fluorometric assay lacks specificity and sensitivity. The radioenzymatic assay is significantly more sensitive and specific...

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“…A gold nanoparticle-doped DNA composite electrode has been used for the detection of norepinephrine in the presence of ascorbic acid (Lu 2004). A nanostructured platinum-gold (Pt–Au) hybrid film modified glassy carbon electrode fabricated by electro-deposition (Thiagarajan 2009) was able to detect both epinephrine and norepinephrine individually and in the presence of ascorbic acid. Simultaneous determination of epinephrine and norepinephrine was investigated by square wave voltammetry using multi-walled carbon nanotubes modified edge plane pyrolytic graphite electrode (Goyal 2011).…”

Section: Electrochemical Detection Of Monoamine Neurotransmittersmentioning

confidence: 99%

Recent Developments in Electrochemical Sensors for the Detection of Neurotransmitters for Applications in Biomedicine

2015

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Neurotransmitters are important biological molecules that are essential to many neurophysiological processes including memory, cognition, and behavioral states. The development of analytical methodologies to accurately detect neurotransmitters is of great importance in neurological and biological research. Specifically designed microelectrodes or microbiosensors have demonstrated potential for rapid, real-time measurements with high spatial resolution. Such devices can facilitate study of the role and mechanism of action of neurotransmitters and can find potential uses in biomedicine. This paper reviews the current status and recent advances in the development and application of electrochemical sensors for the detection of small-molecule neurotransmitters. Measurement challenges and opportunities of electroanalytical methods to advance study and understanding of neurotransmitters in various biological models and disease conditions are discussed.

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Applications of nanostructured Pt-Au hybrid film for the simultaneous determination of catecholamines in the presence of ascorbic acid

Cited by 23 publications

References 36 publications

Palladium nanoparticles modified electrode for the selective detection of catecholamine neurotransmitters in presence of ascorbic acid

Palladium nanoparticles modified electrode for the selective detection of catecholamine neurotransmitters in presence of ascorbic acid

Photoelectroanalytical Detection of Adrenaline Based on DNA and TiO2 Nanoparticles Sensitized with Bis(ethylenedithio)tetrathiafulvalene Exploiting LED Light

Recent Developments in Electrochemical Sensors for the Detection of Neurotransmitters for Applications in Biomedicine

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