Applications of Nanopharmaceuticals in Delivery and Targeting

Ibrahim, Mohamed A.; Abdellatif, Ahmed A. H.

doi:10.1007/978-3-030-44925-4_2

Cited by 4 publications

(4 citation statements)

References 195 publications

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“…Nanoparticles of polymers can be loaded with a high concentration of a drug substance, but due to its inclusion in the nanoparticles it does not cause harm to the body [ 84 , 85 ]. The drug included in nanoparticles is protected from the body’s environment, helping it to maintain its bioactivity [ 86 , 87 , 88 ].…”

Section: Main Applications Of Biodegradable Polymeric Nanoparticlesmentioning

confidence: 99%

Biopolymeric Nanoparticles–Multifunctional Materials of the Future

et al. 2022

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Nanotechnology plays an important role in biological research, especially in the development of delivery systems with lower toxicity and greater efficiency. These include not only metallic nanoparticles, but also biopolymeric nanoparticles. Biopolymeric nanoparticles (BPNs) are mainly developed for their provision of several advantages, such as biocompatibility, biodegradability, and minimal toxicity, in addition to the general advantages of nanoparticles. Therefore, given that biopolymers are biodegradable, natural, and environmentally friendly, they have attracted great attention due to their multiple applications in biomedicine, such as drug delivery, antibacterial activity, etc. This review on biopolymeric nanoparticles highlights their various synthesis methods, such as the ionic gelation method, nanoprecipitation method, and microemulsion method. In addition, the review also covers the applications of biodegradable polymeric nanoparticles in different areas—especially in the pharmaceutical, biomedical, and agricultural domains. In conclusion, the present review highlights recent advances in the synthesis and applications of biopolymeric nanoparticles and presents both fundamental and applied aspects that can be used for further development in the field of biopolymeric nanoparticles.

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Section: Main Applications Of Biodegradable Polymeric Nanoparticlesmentioning

confidence: 99%

Biopolymeric Nanoparticles–Multifunctional Materials of the Future

et al. 2022

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“…Therefore, to coat specific ligands such as antibodies, peptides, designed proteins or nucleic acid on the surface of the nanoparticles for its delivery to the targeted sites is significant [36]. The small molecules are the most prominent targeting agents due to their advantages such as ease of preparation, solidity, and chemical phenomenon [37]. How ever, nanoparticulates can enter the human body via nebulizing, parental and direct administered intake.…”

Section: Targeted Drug Deliverymentioning

confidence: 99%

Nanomedicines: A Focus on Nanomaterials as Drug Delivery System with Current Trends and Future Advancement

et al. 2022

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The rapid advancement of nanomedicine presents novel alternatives that have the potential to transform health care. Targeted drug delivery as well as the synthesis of nanocarriers is a growing discipline that has been intensively researched to reduce the complexity of present medicines in a variety of diseases and to develop new treatment and diagnostic techniques. There are several designed nanomaterials used as a delivery system such as liposomes, micelles, dendrimers, polymers, carbon-based materials, and many other substances, which deliver the drug moiety directly into its targeted body area reducing toxic effect of conventional drug delivery, thus reducing the amount of drug required for therapeutic efficacy and offering many more advantages. Currently, these are used in many applications, including cancer treatment, imaging contrast agents, and biomarker detection and so on. This review provides a comprehensive update in the field of targeted nano-based drug delivery systems, by conducting a thorough examination of the drug synthesis, types, targets, and application of nanomedicines in improving the therapeutic efficiency.

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“…SPIONs are utilized as iron supplements in anaemic patients due to their non-toxic and bio-compatible nature [ 38 ]. They are also being examined for imaging vasculature and tumors [ 39 ], gene therapy, drug delivery [ 40 ], tracing of labeled cells [ 41 ], thermal ablation of tumors via magnetic heating [ 42 ], and organ preservation [ 43 ]. Within the last decade, the Food and Drug Administration (FDA)’s approval of ferumoxytol (Feraheme) to nurse patients with iron deficiency and chronic kidney disease highlighted the clinical applicability of SPIONs in therapy [ 44 ].…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Nanoparticles Functionalised with Re(I) Tricarbonyl Complexes for Cancer Theranostics

Mkhatshwa

Moremi

Makgopa

et al. 2021

IJMS

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Globally, cancer is the second (to cardiovascular diseases) leading cause of death. Regardless of various efforts (i.e., finance, research, and workforce) to advance novel cancer theranostics (diagnosis and therapy), there have been few successful attempts towards ongoing clinical treatment options as a result of the complications posed by cancerous tumors. In recent years, the application of magnetic nanomedicine as theranostic devices has garnered enormous attention in cancer treatment research. Magnetic nanoparticles (MNPs) are capable of tuning the magnetic field in their environment, which positively impacts theranostic applications in nanomedicine significantly. MNPs are utilized as contrasting agents for cancer diagnosis, molecular imaging, hyperfusion region visualization, and T cell-based radiotherapy because of their interesting features of small size, high reactive surface area, target ability to cells, and functionalization capability. Radiolabelling of NPs is a powerful diagnostic approach in nuclear medicine imaging and therapy. The use of luminescent radioactive rhenium(I), 188/186Re, tricarbonyl complexes functionalised with magnetite Fe3O4 NPs in nanomedicine has improved the diagnosis and therapy of cancer tumors. This is because the combination of Re(I) with MNPs can improve low distribution and cell penetration into deeper tissues.

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Applications of Nanopharmaceuticals in Delivery and Targeting

Cited by 4 publications

References 195 publications

Biopolymeric Nanoparticles–Multifunctional Materials of the Future

Biopolymeric Nanoparticles–Multifunctional Materials of the Future

Nanomedicines: A Focus on Nanomaterials as Drug Delivery System with Current Trends and Future Advancement

Nanoparticles Functionalised with Re(I) Tricarbonyl Complexes for Cancer Theranostics

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