Applications of Nanomaterials in Neurological Diseases, Neuronal Differentiation, Neuronal Protection, and Neurotoxicity

Alhibshi, Amani; Alamoudi, Widyan; Farooq, Rai Khalid

doi:10.1007/978-981-15-4802-4_6

Cited by 4 publications

(1 citation statement)

References 263 publications

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“…CNS diseases pose a major threat to human health, and BBB’s presence makes targeted drug delivery a huge challenge. Engineered nanomaterials can be used to provide neuroprotective strategies to overcome the challenges to some extent ( Alhibshi et al, 2020 ). The researchers developed naringenin-loaded solid lipid NPs of 210 nm and showed that the NPs effectively enhanced the neuroprotective effects of naringenin by inhibiting autophagy and enhancing mitochondrial membrane potential, which may be a promising option for the prevention of neurological disorders through autophagy inhibition ( Conklin et al, 2022 ; Nouri et al, 2022 ).…”

Section: Chronic Inflammatory Diseases and Nanomaterialsmentioning

confidence: 99%

The applications of functional materials-based nano-formulations in the prevention, diagnosis and treatment of chronic inflammation-related diseases

Wang

Peng

et al. 2023

Front. Pharmacol.

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Chronic inflammation, in general, refers to systemic immune abnormalities most often caused by the environment or lifestyle, which is the basis for various skin diseases, autoimmune diseases, cardiovascular diseases, liver diseases, digestive diseases, cancer, and so on. Therapeutic strategies have focused on immunosuppression and anti-inflammation, but conventional approaches have been poor in enhancing the substantive therapeutic effect of drugs. Nanomaterials continue to attract attention for their high flexibility, durability and simplicity of preparation, as well as high profitability. Nanotechnology is used in various areas of clinical medicine, such as medical diagnosis, monitoring and treatment. However, some related problems cannot be ignored, including various cytotoxic and worsening inflammation caused by the nanomaterials themselves. This paper provides an overview of functional nanomaterial formulations for the prevention, diagnosis and treatment of chronic inflammation-related diseases, with the intention of providing some reference for the enhancement and optimization of existing therapeutic approaches.

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Section: Chronic Inflammatory Diseases and Nanomaterialsmentioning

confidence: 99%