Applications of nanomaterials in liquid chromatography: Opportunities for separation with high efficiency and selectivity

Zhang, Zhengxiang; Wang, Zhiyong; Liao, Yiping; Liu, Huwei

doi:10.1002/jssc.200600154

Cited by 77 publications

(43 citation statements)

References 64 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The structure of single-walled carbon nanotubes (SWCNTs) can be envisaged as the folding of one single layer of graphite into the tubular form with seamless joining of the edges [5]. Due to their non-polar properties, tremendous efforts have been made to overcome the major technical barrier of its poor water solubility.…”

Section: Introductionmentioning

confidence: 99%

Single-walled carbon nanotube-based polymer monoliths for the enantioselective nano-liquid chromatographic separation of racemic pharmaceuticals

Ahmed

Yajadda

Han

et al. 2014

Journal of Chromatography A

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Single-walled carbon nanotube-based polymer monoliths for the enantioselective nano-liquid chromatographic separation of racemic pharmaceuticals

Ahmed

Yajadda

Han

et al. 2014

Journal of Chromatography A

View full text Add to dashboard Cite

“…[16][17][18][19][20][21][22][23] The addition of nanomaterials was achieved either prior to monolith in situ polymerization or immobilized after the monolith is formed, i.e., form chemical bonds with the functional groups present on the monolith surface. The rationale to choose nanomaterials as anchors is due to their impressive inherent physical and chemical properties that enhance the separation performance of the monoliths.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial Fused Monolithic Microcolumns for Biomolecule Separation

Vijayalakshmi¹,

Tetala²

2018

View full text Add to dashboard Cite

Achieving a highly pure biomolecule of interest is of great importance and chromatography based techniques are the reliable tools for this challenging task. During the last few decades, monoliths have been explored as alternative chromatography stationary phases for biomolecule separation. In this Minireview, we aim to provide information on different nanomaterials incorporated within the network of monoliths and strategies applied to perform nanomaterial surface functionalization. Subsequently, the applications of "nanomaterials embedded monolithic microcolumns" for separation of target biomolecules such as proteins and peptides with the help of different chromatography principles such as affinity, ionic and hydrophobic is also discussed in detail.

show abstract

“…The specific properties of nanoparticles such as carbon (or boron nitride) nanotubes are of particular interest in separation science [1][2][3][4][5]. They could improve the analytical performances of the chromatographic methods such as higher resolution and chromatographic retention or better repeatability and stability due to the specific 1 3…”

Section: Introductionmentioning

confidence: 99%

A Novel Fluorinated Boron Nitride Nanotube Organic Monolithic Column for Capillary Liquid Chromatography

2014

View full text Add to dashboard Cite

interactions between the analyte and the carbon nanotube (electrostatic interactions, π-π stacking, dispersion forces, hydrophobic effect, etc). The interest of the incorporation of boron nitride nanotubes (BNNTs) [6] or single wall carbon nanotubes (SWCNT) [7] into a polymeric chromatographic support to enhance the performance of the HPLC isocratic mode separation quality for small size molecules was clearly demonstrated. The performance of the monolithic column indicated that SWCNTs and BNNTs could enhance the chromatographic retention of small neutral molecules due to the hydrophobic interactions between nanotubes and analytes. Acid-treated SWCNT and MWCNT were coated into fused silica capillaries columns and used for capillary electrochromatography (CEC) applications; these capillaries were applied for base line separation of a mixture of seven nitrogen-containing aromatic compounds [8] and for the electrophoretic determination of different pharmaceutical compounds [9]. Fluorinated stationary phases generated specific selectivity, different elution orders for some class of compounds than those observed on the classical alkyl C8 or C18 stationary phases [10][11][12][13][14][15]. Nanotubes are insoluble in most common solvents; this poor solubility is the main obstacle of their using. Many efforts have been made to overcome this barrier, and various strategies including surface modifications and functionalization approaches have been reported in the literature. The aim of this study was to investigate the influence of BNNT and F-BNNT on chromatographic retention and separation properties of a monolithic polymeric stationary phase. A simple way was described to prepare and maintain a uniform matrix in the capillary column. The fabricated columns were characterized and their performance evaluated for the retention and separation of different model compounds.Abstract A novel HPLC stationary phase based on fluorinated boron nitride nanotubes (F-BNNTs) incorporated into a monolithic polymeric material was developed. This F-BNNT stationary phase was synthesized to combine the analytical performance of boron nitride nanotubes and the fluorine-based unique selectivity for polar compounds. This F-BNNT column appeared to work well when fluorinated or halogenated compounds were encountered.

show abstract

Applications of nanomaterials in liquid chromatography: Opportunities for separation with high efficiency and selectivity

Cited by 77 publications

References 64 publications

Single-walled carbon nanotube-based polymer monoliths for the enantioselective nano-liquid chromatographic separation of racemic pharmaceuticals

Single-walled carbon nanotube-based polymer monoliths for the enantioselective nano-liquid chromatographic separation of racemic pharmaceuticals

Nanomaterial Fused Monolithic Microcolumns for Biomolecule Separation

A Novel Fluorinated Boron Nitride Nanotube Organic Monolithic Column for Capillary Liquid Chromatography

Contact Info

Product

Resources

About