Applications of Metabolomics Analysis in Environmental Research

Bedia, Carmen; Cardoso, Paulo; Dalmau, Núria; Garreta-Lara, Elba; Gómez‐Canela, Cristian; Gorrochategui, Eva; Navarro-Reig, Meritxell; Ortiz-Villanueva, Elena; Puig‐Castellví, Francesc; Tauler, Romà

doi:10.1016/bs.coac.2018.07.006

Cited by 17 publications

(6 citation statements)

References 196 publications

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“…Plants subjected to drought stress are generally affected due to limited water uptake from the roots or excessive transpiration rates from high temperatures [ 25 ]. Current trends in climate change are expected to exacerbate the impacts of drought on global crop productivity due to increased temperature and unstable rainfalls, which could increase drought severity by 20% [ 25 , 79 ]. Metabolomics profiling of crops and model plants has been performed to elucidate plant responses to drought conditions, evaluate plant adaptations to drought stress, and discover metabolic biomarkers for stress tolerance.…”

Section: Current Applications Of Plant Metabolomics In Crop Improvementmentioning

confidence: 99%

Metabolomics and Chemoinformatics in Agricultural Biotechnology Research: Complementary Probes in Unravelling New Metabolites for Crop Improvement

Mashabela

Masamba

Kappo

2022

Biology

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The United Nations (UN) estimate that the global population will reach 10 billion people by 2050. These projections have placed the agroeconomic industry under immense pressure to meet the growing demand for food and maintain global food security. However, factors associated with climate variability and the emergence of virulent plant pathogens and pests pose a considerable threat to meeting these demands. Advanced crop improvement strategies are required to circumvent the deleterious effects of biotic and abiotic stress and improve yields. Metabolomics is an emerging field in the omics pipeline and systems biology concerned with the quantitative and qualitative analysis of metabolites from a biological specimen under specified conditions. In the past few decades, metabolomics techniques have been extensively used to decipher and describe the metabolic networks associated with plant growth and development and the response and adaptation to biotic and abiotic stress. In recent years, metabolomics technologies, particularly plant metabolomics, have expanded to screening metabolic biomarkers for enhanced performance in yield and stress tolerance for metabolomics-assisted breeding. This review explores the recent advances in the application of metabolomics in agricultural biotechnology for biomarker discovery and the identification of new metabolites for crop improvement. We describe the basic plant metabolomics workflow, the essential analytical techniques, and the power of these combined analytical techniques with chemometrics and chemoinformatics tools. Furthermore, there are mentions of integrated omics systems for metabolomics-assisted breeding and of current applications.

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Section: Current Applications Of Plant Metabolomics In Crop Improvementmentioning

confidence: 99%

Metabolomics and Chemoinformatics in Agricultural Biotechnology Research: Complementary Probes in Unravelling New Metabolites for Crop Improvement

Mashabela

Masamba

Kappo

2022

Biology

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“…Metabolomics is clearly correlated with the functionality of the organism, while the other “omics” such as genomics, transcriptomics and proteomics, are closest to its capabilities ( Figure 1 ). While the applications of metabolomics are numerous and varied in areas such as food and natural products quality controls ( Lee et al, 2017 ; Li et al, 2021 ), environmental studies ( Viant, 2009 ; Bedia et al, 2018 ) or agriculture ( Kumar et al, 2017 ), the most highlighted and probably the most promising application fields of this methodology are clinical metabolomics and personalized medicine ( Wishart, 2016 ; Li B. et al, 2017 ; Kohler et al, 2017 ; Nielsen, 2017 ; Tolstikov et al, 2017 ; Trivedi et al, 2017 ; Jacob et al, 2019 ; Pang et al, 2019 ). Clinical metabolomics is a general terminology that deals with all the applications of this approach that involve human subjects.…”

Section: Clinical Metabolomics and Personalized Medicinementioning

confidence: 99%

Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives

Letertre

Giraudeau

Tullio

2021

Front. Mol. Biosci.

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Personalized medicine is probably the most promising area being developed in modern medicine. This approach attempts to optimize the therapies and the patient care based on the individual patient characteristics. Its success highly depends on the way the characterization of the disease and its evolution, the patient’s classification, its follow-up and the treatment could be optimized. Thus, personalized medicine must combine innovative tools to measure, integrate and model data. Towards this goal, clinical metabolomics appears as ideally suited to obtain relevant information. Indeed, the metabolomics signature brings crucial insight to stratify patients according to their responses to a pathology and/or a treatment, to provide prognostic and diagnostic biomarkers, and to improve therapeutic outcomes. However, the translation of metabolomics from laboratory studies to clinical practice remains a subsequent challenge. Nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) are the two key platforms for the measurement of the metabolome. NMR has several advantages and features that are essential in clinical metabolomics. Indeed, NMR spectroscopy is inherently very robust, reproducible, unbiased, quantitative, informative at the structural molecular level, requires little sample preparation and reduced data processing. NMR is also well adapted to the measurement of large cohorts, to multi-sites and to longitudinal studies. This review focus on the potential of NMR in the context of clinical metabolomics and personalized medicine. Starting with the current status of NMR-based metabolomics at the clinical level and highlighting its strengths, weaknesses and challenges, this article also explores how, far from the initial “opposition” or “competition”, NMR and MS have been integrated and have demonstrated a great complementarity, in terms of sample classification and biomarker identification. Finally, a perspective discussion provides insight into the current methodological developments that could significantly raise NMR as a more resolutive, sensitive and accessible tool for clinical applications and point-of-care diagnosis. Thanks to these advances, NMR has a strong potential to join the other analytical tools currently used in clinical settings.

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“…VOCs are numerous, varied, and ubiquitous. The list of these compounds amounts to more than 1000 species [ 115 ]. However, only a few of these are recurrent in gas sensing studies (e.g., ethanol, methanol, acetone, benzene, toluene, formaldehyde, or acetaldehyde) probably because of their abundance in the industry and the indoor/outdoor environment, and their significance as biomarkers in disease diagnosis, as summarized in Table 1 .…”

Section: Selectivity—in Search Of Specificitymentioning

confidence: 99%

VOCs Sensing by Metal Oxides, Conductive Polymers, and Carbon-Based Materials

et al. 2021

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This review summarizes the recent research efforts and developments in nanomaterials for sensing volatile organic compounds (VOCs). The discussion focuses on key materials such as metal oxides (e.g., ZnO, SnO2, TiO2 WO3), conductive polymers (e.g., polypyrrole, polythiophene, poly(3,4-ethylenedioxythiophene)), and carbon-based materials (e.g., graphene, graphene oxide, carbon nanotubes), and their mutual combination due to their representativeness in VOCs sensing. Moreover, it delves into the main characteristics and tuning of these materials to achieve enhanced functionality (sensitivity, selectivity, speed of response, and stability). The usual synthesis methods and their advantages towards their integration with microsystems for practical applications are also remarked on. The literature survey shows the most successful systems include structured morphologies, particularly hierarchical structures at the nanometric scale, with intentionally introduced tunable “decorative impurities” or well-defined interfaces forming bilayer structures. These groups of modified or functionalized structures, in which metal oxides are still the main protagonists either as host or guest elements, have proved improvements in VOCs sensing. The work also identifies the need to explore new hybrid material combinations, as well as the convenience of incorporating other transducing principles further than resistive that allow the exploitation of mixed output concepts (e.g., electric, optic, mechanic).

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Applications of Metabolomics Analysis in Environmental Research

Cited by 17 publications

References 196 publications

Metabolomics and Chemoinformatics in Agricultural Biotechnology Research: Complementary Probes in Unravelling New Metabolites for Crop Improvement

Metabolomics and Chemoinformatics in Agricultural Biotechnology Research: Complementary Probes in Unravelling New Metabolites for Crop Improvement

Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives

VOCs Sensing by Metal Oxides, Conductive Polymers, and Carbon-Based Materials

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