Applications of Laser Speckle Contrast Imaging Technology in Dermatology

Linkous, Courtney; Pagan, Angel D; Shope, Chelsea; Andrews, Laura; Snyder, Alan; Ye, Tong; Valdebran, Manuel

doi:10.1016/j.xjidi.2023.100187

Cited by 7 publications

(3 citation statements)

References 33 publications

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“…Particularly, LSCI is extensively used for assessment of wounds, burns, and ulcers healing monitoring, port wine stain (PWS) birthmark treatment, perfusion studying, and so on. [187,[199][200][201][202][203][204][205] Guven et al [206] presented a comparison of LSCI with LDF perfusion imaging for tissue perfusion assessment. Both techniques showed a strong linear correlation in perfusion measurements.…”

Section: Skin Perfusion Monitoringmentioning

confidence: 99%

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Advances in Dynamic Light Scattering Imaging of Blood Flow

Sdobnov,

Piavchenko,

Bykov

et al. 2023

Laser & Photonics Reviews

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Dynamic light scattering (DLS) is a well known experimental approach uniquely suited for the characterization of small particles undergoing Brownian motion in randomly inhomogeneous turbid scattering medium, including water suspension, polymers in solutions, cells cultures, and so on. DLS is based on the illuminating of turbid medium with a coherent laser light and further analyzes the intensity fluctuations caused by the motion of the scattering particles. The DLS‐based spin‐off derivative techniques, such laser Doppler flowmetry (LDF), diffusing wave spectroscopy (DWS), laser speckle contrast imaging (LSCI), and Doppler optical coherence tomography (DOCT), are exploited widely for non‐invasive imaging of blood flow in brain, skin, muscles, and other biological tissues. The recent advancements in the DLS‐based imaging technologies in frame of their application for brain blood flow monitoring, skin perfusion measurements, and non‐invasive blood micro‐circulation characterization are overviewed. The fundamentals, breakthrough potential, and practical findings revealed by DLS‐based blood flow imaging studies, including the limitations and challenges of the approach such as movement artifacts, non‐ergodicity, and overcoming high scattering properties of studied medium, are also discussed. It is concluded that continued research and further technological advancements in DLS‐based imaging will pave the way for new exciting developments and insights into blood flow diagnostic imaging.

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Section: Skin Perfusion Monitoringmentioning

confidence: 99%

Section: Recent Progress In Dls‐based Imaging Of Blood Flowmentioning

confidence: 99%

Advances in Dynamic Light Scattering Imaging of Blood Flow

Sdobnov,

Piavchenko,

Bykov

et al. 2023

Laser & Photonics Reviews

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“…Among the myriad noninvasive methods available for skin perfusion assessment, unlike on skin flaps, only a few, such as optical coherence tomography, laser Doppler imaging, infrared thermal imaging, or laser speckle contrast imaging (LSCI), have been employed on skin grafts [6][7][8][9]. We highlight the advantages of LSCI over the other techniques, namely the rapid and contactless perfusion assessment with an excellent spatial and temporal resolution, making it suitable for studying the skin graft microcirculation at once, including in the intraoperative setting [10][11][12].…”

mentioning

confidence: 99%

Postoperative Time and Anatomic Location Influence Skin Graft Reperfusion Assessed With Laser Speckle Contrast Imaging

Pinho,

Brinca,

Xará

et al. 2024

Lasers Surg Med

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ObjectivesUnder optimal conditions, afferent and efferent human skin graft microcirculation can be restored 8–12 days postgrafting. Still, the evidence about the reperfusion dynamics beyond this period in a dermato‐oncologic setting is scant. We aimed to characterise the reperfusion of human skin grafts over 4 weeks according to the necrosis extension (less than 20%, or 20%–50%) and anatomic location using laser speckle contrast imaging (LSCI).MethodsOver 16 months, all eligible adults undergoing skin grafts following skin cancer removal on the scalp, face and lower limb were enroled. Perfusion was assessed with LSCI on the wound margin (control skin) on day 0 and on the graft surface on days 7, 14, 21 and 28. Graft necrosis extension was determined on day 28.ResultsForty‐seven grafts of 47 participants were analysed. Regardless of necrosis extension, graft perfusion equalled the control skin by day 7, surpassed it by day 21, and stabilised onwards. Grafts with less than 20% necrosis on the scalp and lower limb shared this reperfusion pattern and had a consistently better‐perfused centre than the periphery for the first 21 days. On the face, the graft perfusion did not differ from the control skin from day 7 onwards, and there were no differences in reperfusion within the graft during the study.ConclusionSkin graft reperfusion is a protracted process that evolves differently in the graft centre and periphery, influenced by postoperative time and anatomic location. A better knowledge of this process can potentially enhance the development of strategies to induce vessel ingrowth into tissue‐engineered skin substitutes.

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