“…In the future, with the potential emergence of new compression or new segmentation techniques, especially with the ongoing development of artificial intelligence (AI) based methods [ 36 , 37 ], the concept of a multi-level compression approach could still be used, with automatic segmentation of any pre-defined PROIs, SROIs, and background, to achieve even greater results in terms of compression ratio, while maintaining satisfactory image quality. Although the reduced image size in our proposed approach finds its main application in data storage optimization (i.e., image archiving), it could also benefit other domains in radiology, for example in the growing field of teleradiology [ 38 , 39 ], where it could lead to faster data transfers and reduced bandwidth requirements.…”