Applications of hydrothermal synthesis of Escherichia coli derived carbon dots in in vitro and in vivo imaging and p-nitrophenol detection

Qin, Kunhao; Zhang, Dongfang; Ding, Yafang; Zheng, Xiaodan; Xiang, Yingying; Hua, Jianhao; Zhang, Qi; Ji, Xiuling; Li, Bo; Wei, Yunlin

doi:10.1039/c9an01753d

Cited by 67 publications

(21 citation statements)

References 38 publications

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“… 61 In a recent work, CDs derived from Escherichia coli (CDs-WT) showed the ability to permeate mouse skin and tissues. 62 When CDs were injected into mice, strong fluorescence signals in intestinal region were observed up to 12 hours after injection. The fluorescence signals disappeared after 24 hours of injection indicating a rapid excretion of CDs.…”

Section: Penetration Of Biological Barriers With Carbon Dotsmentioning

confidence: 99%

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Zhang

Sigdel

Mintz

et al. 2021

IJN

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Drug delivery across the blood–brain barrier (BBB) is one of the biggest challenges in modern medicine due to the BBB’s highly semipermeable property that limits most therapeutic agents of brain diseases to enter the central nervous system (CNS). In recent years, nanoparticles, especially carbon dots (CDs), exhibit many unprecedented applications for drug delivery. Several types of CDs and CD-ligand conjugates have been reported successfully penetrating the BBB, which shows a promising progress in the application of CD-based drug delivery system (DDS) for the treatment of CNS diseases. In this review, our discussion of CDs includes their classification, preparations, structures, properties, and applications for the treatment of neurodegenerative diseases, especially Alzheimer’s disease (AD) and brain tumor. Moreover, abundant functional groups on the surface, especially amine and carboxyl groups, allow CDs to conjugate with diverse drugs as versatile drug nanocarriers. In addition, structure of the BBB is briefly described, and mechanisms for transporting various molecules across the BBB and other biological barriers are elucidated. Most importantly, recent developments in drug delivery with CDs as BBB-penetrating nanodrugs and drug nanocarriers to target CNS diseases especially Alzheimer’s disease and brain tumor are summarized. Eventually, future prospects of the CD-based DDS are discussed in combination with the development of artificial intelligence and nanorobots.

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Section: Penetration Of Biological Barriers With Carbon Dotsmentioning

confidence: 99%

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Zhang

Sigdel

Mintz

et al. 2021

IJN

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“…Besides the high quantum yield and adjustable emission wavelength, which are also possessed by traditional semiconductor quantum dots, C-dots have many other excellent characteristics, including good photostability, low cytotoxicity, good biocompatibility, easy surface modification and high chemical inertness, and therefore have attracted considerable scholarly attention in recent years. Hence far, C-dots have been widely used in many fields such as cell imaging [3][4][5], in vivo imaging [6,7], drug delivery [8][9][10], fluorescence sensing [11][12][13], photocatalysis [14][15][16], multicolor light-emitting diode (LED) production [17,18], energy conversion and storage [19][20][21], etc. C-dots are gradually become one of the research hotspots in the above-mentioned fields and considered as a potential substitute for semiconductor quantum dots.…”

Section: Introductionmentioning

confidence: 99%

A Review of Carbon Dots Produced from Biomass Wastes

et al. 2020

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The fluorescent carbon dot is a novel type of carbon nanomaterial. In comparison with semiconductor quantum dots and fluorescence organic agents, it possesses significant advantages such as excellent photostability and biocompatibility, low cytotoxicity and easy surface functionalization, which endow it a wide application prospect in fields of bioimaging, chemical sensing, environmental monitoring, disease diagnosis and photocatalysis as well. Biomass waste is a good choice for the production of carbon dots owing to its abundance, wide availability, eco-friendly nature and a source of low cost renewable raw materials such as cellulose, hemicellulose, lignin, carbohydrates and proteins, etc. This paper reviews the main sources of biomass waste, the feasibility and superiority of adopting biomass waste as a carbon source for the synthesis of carbon dots, the synthetic approaches of carbon dots from biomass waste and their applications. The advantages and deficiencies of carbon dots from biomass waste and the major influencing factors on their photoluminescence characteristics are summarized and discussed. The challenges and perspectives in the synthesis of carbon dots from biomass wastes are also briefly outlined.

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“…After that, CDs have received extensive and significant attention owing to their unique structure and fascinating properties in different fields. As one of the new allotropes of carbon, CDs show many remarkable advantages, such as low cytotoxicity [7], good biocompatibility [8], stable chemical inertness [9], efficient light harvesting [9] and outstanding photoinduced electron transfer [10], thus making them promising candidates for various applications in biosensors [11][12][13], bioimaging [14,15], optoelectronic devices [16,17], solar cells, etc. [18,19].…”

Section: Introductionmentioning

confidence: 99%

Carbon Dots: Synthesis, Properties and Applications

Ren²,

et al. 2021

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Carbon dots (CDs) are known as the rising star of carbon-based nanomaterials and, by virtue of their unique structure and fascinating properties, they have attracted considerable interest in different fields such as biological sensing, drug delivery, photodynamic therapy, photocatalysis, and solar cells in recent years. Particularly, the outstanding electronic and optical properties of the CDs have attracted increasing attention in biomedical and photocatalytic applications owing to their low toxicity, biocompatibility, excellent photostability, tunable fluorescence, outstanding efficient up-converted photoluminescence behavior, and photo-induced electron transfer ability. This article reviews recent progress on the synthesis routes and optical properties of CDs as well as biomedical and photocatalytic applications. Furthermore, we discuss an outlook on future and potential development of the CDs based biosensor, biological dye, biological vehicle, and photocatalysts in this booming research field.

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Applications of hydrothermal synthesis of Escherichia coli derived carbon dots in in vitro and in vivo imaging and p-nitrophenol detection

Abstract: The schematic of the synthesis route for fluorescent CDs-WT and the applications in the bioimaging and detection for p-NP is presented.

Cited by 67 publications

References 38 publications

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

A Review of Carbon Dots Produced from Biomass Wastes

Carbon Dots: Synthesis, Properties and Applications

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