Applications of High Performance Liquid Chromatography in the Petroleomic Analysis of Crude Oil: A Mini-Review

Abstract

High performance liquid chromatography (HPLC) is a well established analytical technique in the study of crude oil, and it has recently become more integrated within the field of petroleomics as a first step before high-resolution mass spectrometric analysis. This mini-review summarizes and discusses the applications of HPLC for the analyses of crude oil and its related products that have been published over the last 10 years. A brief introduction to separation science is provided, and applications are divided by compound class (group-type separations, heteroatoms, and other specialty analytes). Special attention is paid to applications that specifically couple to Fourier Transform ion cyclotron resonance mass spectrometry, and these are discussed in a separate section.

2021 Pioneers in Energy Research: Alan Marshall

“…Heshka provided a mini-review on the application of high-performance liquid chromatography for petroleum characterization. The historical perspective and recent progress on the integration with mass spectrometry within the past decade were reviewed.…”

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