Applications of Hadamard transform-gas chromatography/mass spectrometry to the detection of acetone in healthy human and diabetes mellitus patient breath

Fan, Gang; Yang, Chien Lin; Lin, Cheng Huang; Chen, Chien‐Chung; Shih, Chun‐Hsing

doi:10.1016/j.talanta.2013.12.025

Cited by 77 publications

(45 citation statements)

References 47 publications

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“…Studies have also found a high correlation between BGL and the concentration of breath acetone [165, 185, 186, 195, 197, 198] in patients with diabetes. The exhaled breath acetone concentration has been reported to be in the range of 0.044 ppm [199] to 2.744 ppm [83] for normal healthy subjects, 2.2 ppm [200] to 21 ppm [165, 201] for type 1 diabetes patients, and 1.76 ppm [165, 183] to 9.4 ppm [200] for type 2 diabetes patients. The elevation of acetone level indicates either a deficit of insulin in cells or cells’ inability to effectively utilize available insulin [28].…”

Section: Relating Breath Vocs To Diabetes Mellitusmentioning

confidence: 99%

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

2016

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Analysis of volatile organic compounds (VOCs) emanating from human exhaled breath can provide deep insight into the status of various biochemical processes in the human body. VOCs can serve as potential biomarkers of physiological and pathophysiological conditions related to several diseases. Breath VOC analysis, a noninvasive and quick biomonitoring approach, also has potential for the early detection and progress monitoring of several diseases. This paper gives an overview of the major VOCs present in human exhaled breath, possible biochemical pathways of breath VOC generation, diagnostic importance of their analysis, and analytical techniques used in the breath test. Breath analysis relating to diabetes mellitus and its characteristic breath biomarkers is focused on. Finally, some challenges and limitations of the breath test are discussed.

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Section: Relating Breath Vocs To Diabetes Mellitusmentioning

confidence: 99%

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

2016

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“…They can be divided into two groups: on-line methods, i.e. proton transfer reaction mass spectrometry (PTR-MS) [20], atmospheric pressure chemical ionization mass spectrometry (APCI-MS) [21] and off-line methods such as: gas chromatography -mass spectrometry (GC-MS) [22], selected ion flow tube mass spectrometry (SIFT-MS) [23] based on sample preconcentration. Those methods are in fact very expensive and required a well qualified personnel, therefore their use is exclusively restricted to the laboratories.…”

Section: Introductionmentioning

confidence: 99%

Microsystem in LTCC Technology to the Detection of Acetone in Exhaled Breath

Rydosz¹

2015

IJIEE

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An acetone is a well-known diabetes biomarker, since patients with diabetes tend to have higher acetone levels in their breath than healthy people. Exhaled acetone levels are usually in the range of 0.3-0.9 ppm (parts per million) for healthy subjects and over 3 ppm for patients with diabetes. Commercially-available gas sensors are under development for measuring samples at several tens ppm. Due to this fact, the microsystem with micropreconcentrator and sensor array is proposed as a solution that overcomes these limitations. The microsystem designed by author was manufactured in LTCC (Low Temperature Cofired Ceramics) technology. The microsystem based on micropreconcentrator structure as well as metal oxide gas sensors array. Acetone in diabetic breath was found to be higher than 1.11 ppm, while its concentration in normal breath was lower than 0.83 ppm. Index Terms-Breath analysis, low temperature cofired ceramics (LTCC), exhaled acetone measurements, micropreconcentrators.A. Rydosz received the M.Sc. and Ph.D. degrees in electronic engineering from the AGH University of Science and Technology, Krakow, Poland in 2009 and 2014, respectively. His current research interests include gas sensors and micropreconcentrators, LTCC, MEMS technology as well as gas sensors system applications.

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“…Additionally, the medical reports show that a large amount of acetone is generated and acetone concentration is found to elevate by about two degrees of magnitude in the plasma of diabetic patients [5][6][7]. Hence, acetone is generally regarded as an important biomarker of diabetes or accessorial tool for diabetes diagnosis [8][9][10][11][12][13][14][15][16]. The commonly analytical techniques for determining acetone for diabetes diagnosis are based on derivatization techniques or mass spectrometry (MS) in conjunction with separation techniques, such as highperformance liquid chromatography (HPLC), gas chromatography (GC) [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Hence, acetone is generally regarded as an important biomarker of diabetes or accessorial tool for diabetes diagnosis [8][9][10][11][12][13][14][15][16]. The commonly analytical techniques for determining acetone for diabetes diagnosis are based on derivatization techniques or mass spectrometry (MS) in conjunction with separation techniques, such as highperformance liquid chromatography (HPLC), gas chromatography (GC) [8][9][10][11]. However, the above-mentioned detection methods for acetone often suffer from some disadvantages, such as sophisticated procedures, bulky equipment and low detection sensitivity.…”

Section: Introductionmentioning

confidence: 99%

A novel acetone sensor utilizing cataluminescence on layered double oxide

Zhang

Rong

Chen

et al. 2014

Sensors and Actuators B: Chemical

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a b s t r a c tThis work developed a facile and effective sensor for the determination of acetone, the diabetic biomarker, which was based on cataluminescence (CTL) emission on the surface of layered double oxide (LDO) that is a layered nanomaterial with easy preparation and environmental friendliness. Under the optimized conditions, the linear range of the CTL intensity versus concentration of acetone was 0.1-16 mM with the detection limit of 0.02 mM (S/N = 3). The relative standard deviation (RSD) for 50 repeated measurements of 1.0 mM acetone was 3.6%. Interestingly, there was no or weak response to seven common volatile organic compounds (VOCs), including ethanol, heptanal, ethyl acetate, methanol, formaldehyde, acetic acid and toluene. Furthermore, the proposed CTL sensor was successfully used for sensing acetone in human plasma samples of diabetes patients with a satisfactory recovery. The results demonstrated that the proposed CTL sensor had a promising capability for the sensing of acetone in diabetes diagnosis. The possible CTL mechanism from the oxidation of acetone on the surface of LDO was also discussed.

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Applications of Hadamard transform-gas chromatography/mass spectrometry to the detection of acetone in healthy human and diabetes mellitus patient breath

Cited by 77 publications

References 47 publications

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

Microsystem in LTCC Technology to the Detection of Acetone in Exhaled Breath

A novel acetone sensor utilizing cataluminescence on layered double oxide

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