Applications of Fungal Polysaccharides

Osińska-Jaroszuk, Monika; Sulej, Justyna; Jaszek, Magdalena; Jaroszuk-Ściseł, Jolanta

doi:10.1016/b978-0-12-809633-8.21092-3

Cited by 8 publications

(7 citation statements)

References 148 publications

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“…The fungal cell wall is 90% composed of polysaccharides, including glycogen, β-glucan, α-glucan, galactan, mannan, galactomannan, xylomannan, polygalactosaminde, chitin, chitosan, cellulose, and polyuronide [ 6 ]. These polysaccharides play a predominant role in the rheological, growth, pathogenicity, cell protection, resistance, chemical signal transfer, and stress-related pathways of fungi [ 7 ]. Recently, fungal polysaccharides have gained great attention for pharmacological, cosmetic, and food applications due to their biological properties (e.g., antiviral, antimicrobial, antitumor, antioxidant, immunomodulatory, hypolipidemic, hepatoprotective, and hypoglycemic), biodegradability, and biocompatibility [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Isolation of Polysaccharides from Trichoderma harzianum with Antioxidant, Anticancer, and Enzyme Inhibition Properties

et al. 2021

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In this work, a total of six polysaccharides were isolated from culture filtrate (EPS1, EPS2) and mycelia (IPS1–IPS4) of Trichoderma harzianum. The HPLC analysis results showed that EPS1, EPS2, IPS1, and IPS2 were composed of mannose, ribose, glucose, galactose, and arabinose. The FT-IR, 1H, and 13C NMR chemical shifts confirmed that the signals in EPS1 mainly consist of (1→4)-linked α-d-glucopyranose. EPS1 and IPS1 showed a smooth and clean surface, while EPS2, IPS2, and IPS3 exhibited a microporous structure. Among polysaccharides, EPS1 displayed higher ABTS+ (47.09 ± 2.25% and DPPH (26.44 ± 0.12%) scavenging activities, as well as higher α-amylase (69.30 ± 1.28%) and α-glucosidase (68.22 ± 0.64 %) inhibition activity than the other polysaccharides. EPS1 exhibited high cytotoxicity to MDA-MB293 cells, with an IC50 of 0.437 mg/mL, and this was also confirmed by cell staining and FACS assays. These results report the physicochemical and bioactive properties of polysaccharides from T. harzianum.

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Section: Introductionmentioning

confidence: 99%

Isolation of Polysaccharides from Trichoderma harzianum with Antioxidant, Anticancer, and Enzyme Inhibition Properties

et al. 2021

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“…Polysaccharides are the main component (about 90%) of the AC cell wall, and the β-glucan is the central core of the cell wall (Osińska-Jaroszuk et al, 2021). The β-glucan concentration in mush- rooms ranged from 0.21 to 0.53 g/100 g (dry weight basis) (Rop et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The entire fermented culture media was subsequently dried at a low temperature (55 °C) to preserve the bioactivity. As AC strain fermented proteins and carbohydrates are present in culture media, they could produce a wide variety of metabolic products, including amino acids, peptides and polysaccharides, such as β-glucan (Mukhopadhyay and Guha, 2015;Osińska-Jaroszuk et al, 2021), and several undefined metabolites that may have beneficial effects for pigs. The nutrient content of ACC is shown in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Effect of dietary <i>Auricularia cornea</i> culture supplementation on growth performance, serum biochemistry profile and meat quality in growing-finishing pigs

Liu¹,

Ju²,

Liu³

et al. 2021

J. Anim. Feed Sci.

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Auricularia cornea culture (ACC) is a dried product containing Auricularia cornea (AC) mycelium and various metabolites of AC fermentation. The objective of this study was to investigate the effects of dietary ACC supplementation on growth performance, short-chain fatty acid concentration in faeces, serum biochemical profile and meat quality in growing-finishing pigs. In total, 96 growing pigs with initial body weight 91.94 ± 7.59 kg, were allotted to one of four dietary treatments for 45 days. Treatments were: basal diet and three experimental diets with 0.3, 0.6 and 1.2% ACC addition, respectively. It was shown that pigs fed ACC diets had a greater average daily gain (P < 0.05), and also lower glucose content in serum (P < 0.05). In comparison with control animals, in pigs fed diets with ACC an increased butyrate content (P < 0.05) in faeces and greater monocarboxylate transporter 1 (MCT1) mRNA expression (P < 0.05) in the colon were noted. There was also observed an increasing trend concerning a* value (P = 0.09) and the higher polyunsaturated fatty acid contents in longissimus dorsi muscle (P = 0.01). In conclusion, the dietary ACC addition could improve the growth and health of animals as well as meat quality to a certain degree. So, a 1.2% ACC supplementation can be recommended for growing-finishing pigs.

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“…The precipitate ("crude EPS") obtained by centrifugation may contain certain amounts of other substances, such as proteins, minerals, or low molecular mass carbohydrates, leading to the polysaccharide purification step [89]. Ion exchange chromatography (IEC) and gel permeation chromatography (GPC) are methods that can be used for the purification of exopolysaccharides [133]. Regarding the composition and structure of fungal exopolysaccharides, they can usually be analyzed by high-performance liquid chromatography (HPLC), gas-liquid chromatography (GLC), gas-liquid chromatography-mass spectrometry (GLC-MS), and 1D and 2D NMR spectroscopy [5].…”

Section: Extraction and Analytical Methods Of Fungal Exopolysaccharidesmentioning

confidence: 99%

Exopolysaccharides of Fungal Origin: Properties and Pharmaceutical Applications

et al. 2023

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Fungal exopolysaccharides (EPSs) represent an important group of bioactive compounds secreted by fungi. These biopolymers can be utilized individually or in combination with different bioactive substances for a broad range of pharmaceutical field applications, due to their various biological activities, such as antioxidant, antimicrobial, anti-inflammatory, antiviral, anti-diabetic, and anticoagulant effects. The paper presents an up-to-date review of the main fungal polysaccharides (pullulan, schizophyllan, scleroglucan, botryosphaeran, lentinan, grifolan, and lasiodiplodan), highlighting their structures, producing strains, and useful properties in a double position, as controlled release (rate and selectively targeting) drug carriers, but mostly as active immunomodulating and antitumor compounds in cancer therapy.

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Applications of Fungal Polysaccharides

Cited by 8 publications

References 148 publications

Isolation of Polysaccharides from Trichoderma harzianum with Antioxidant, Anticancer, and Enzyme Inhibition Properties

Isolation of Polysaccharides from Trichoderma harzianum with Antioxidant, Anticancer, and Enzyme Inhibition Properties

Effect of dietary <i>Auricularia cornea</i> culture supplementation on growth performance, serum biochemistry profile and meat quality in growing-finishing pigs

Exopolysaccharides of Fungal Origin: Properties and Pharmaceutical Applications

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