Applications of Different Techniques in Estimation of Aggregation and Thermodynamic Behaviour of Brij 58 at Different Temperatures

Abstract

INTRODUCTIONA high percentage of pharmaceutically active compounds are insoluble in water having low and variable bioavailability 1,2 . Therefore, several techniques are in practice to increase the solubility of such drugs including the utility of the surfactants/ amphiphiles [3][4][5][6][7] . Surfactant are the substances that preferentially adsorb at an interface and lower the interfacial tension between two liquids or phases 8 . A large number of surfactants are available in the market, which have wide spread applications in different industries including dyestuffs, cosmetics, detergents, paints, plastic fibers, pesticides, pharmaceuticals and lubricants etc. 9 . The surface activity of surfactants is due to their amphiphilic structure having both a polar or hydrophilic head and a non-polar or a hydrophobic tail 10 . Their vital role in both fundamental and applied sciences is due to their most spectacular property to assemble into higher order structures spontaneously. This process is commonly known as self-assembly. It usually involves molecules that contain two distinct components, differing in their affinity for solutes. Molecules containing both hydrophobic and hydrophilic types of components with distinctive chemical and physical properties are said to be amphiphiles.An amphiphilic molecule can arrange itself at the surface of the water such that the polar part interacts with the water and the non-polar part is held above the surface (either in the air or in a non-polar liquid). The presence of these molecules