Applications of deuterium oxide in human health

Bila, Wendell Costa; Mariano, Reysla Maria da Silveira; Silva, Valmin Ramos da; Santos, Maria Izabel dos; Lamounier, Joel Alves; Ferriolli, Eduardo; Galdino, Alexsandro Sobreira

doi:10.1080/10256016.2017.1281806

Cited by 13 publications

(9 citation statements)

References 92 publications

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“…Among the disadvantages are high cost, time-consuming sample preparation, complex analysis, and the impossibility of determining retention directly. 21 The results obtained follow the model of two-compartment body composition (LM and FM), which does not permit the assessment of body water distribution in different compartments or of BF distribution. For this reason, the method should not be applied to subjects with edema, decompensated heart failure, or other conditions involving changes in body water volume.…”

Section: Discussionmentioning

confidence: 88%

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Comparison of body composition analysis methods among centenary women: Seeking simpler methods

Duarte

Pelichek

et al. 2019

SAGE Open Medicine

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Objectives: The aim of this study was to evaluate the most commonly used body composition tools in clinical practice, such as anthropometry and electrical bioimpedance, and compare it with deuterium oxide. Methods: An exploratory cross-sectional study was conducted on women aged 100 years or above at home. Body composition was determined by measuring skinfolds (Jackson and Pollock and Durnin and Womersley equations), by bioimpedance, and by the deuterium oxide method. Results: Body mass index values were lower than 22 kg/m2 in 64% of the subjects. When the various methods used were compared with deuterium oxide, there was better agreement for the determination of fat mass than lean mass. For fat mass, agreement was better when using bioimpedance (Lin’s coefficient = 0.70), whereas for lean mass, agreement was better using the Durnin and Womersley equation (Lin’s coefficient = 0.51). Conclusion: It is possible to use bioimpedance and skinfolds to evaluate fat mass and lean mass, respectively, in centenarians.

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Section: Discussionmentioning

confidence: 88%

“…Among the disadvantages are high cost, time-consuming sample preparation, complex analysis, and the impossibility of determining retention directly. 21…”

Section: Discussionmentioning

confidence: 99%

Comparison of body composition analysis methods among centenary women: Seeking simpler methods

Duarte

Pelichek

et al. 2019

SAGE Open Medicine

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“…It should be noted that an additional possibility of fractionation is observed for heavy isotopes of hydrogen and oxygen that are part of an activated enzyme–substrate complex due to fixation of 2 H and 18 O from the solvent (water: HDO [39,43,44] or H 2 18 O), in which all biochemical processes (Reactions 2 and 3, Figure 2 and Figure 3) proceed. The latter can lead to a more significant and widespread fractionation of these isotopes in living systems [1,45,46,47,48].…”

Section: Molecular Effects Of 2h/1h Exchangementioning

confidence: 99%

Possible Mechanisms of Biological Effects Observed in Living Systems during 2H/1H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes

et al. 2019

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This article presents the original descriptions of some recent physics mechanisms (based on the thermodynamic, kinetic, and quantum tunnel effects) providing stable 2H/1H isotope fractionation, leading to the accumulation of particular isotopic forms in intra- or intercellular space, including the molecular effects of deuterium interaction with 18O/17O/16O, 15N/14N, 13C/12C, and other stable biogenic isotopes. These effects were observed mainly at the organelle (mitochondria) and cell levels. A new hypothesis for heavy nonradioactive isotope fractionation in living systems via neutron effect realization is discussed. The comparative analysis of some experimental studies results revealed the following observation: “Isotopic shock” is highly probable and is observed mostly when chemical bonds form between atoms with a summary odd number of neutrons (i.e., bonds with a non-compensated neutron, which correspond to the following equation: Nn − Np = 2k + 1, where k ϵ Z, k is the integer, Z is the set of non-negative integers, Nn is number of neutrons, and Np is number of protons of each individual atom, or in pair of isotopes with a chemical bond). Data on the efficacy and metabolic pathways of the therapy also considered 2H-modified drinking and diet for some diseases, such as Alzheimer’s disease, Friedreich’s ataxia, mitochondrial disorders, diabetes, cerebral hypoxia, Parkinson’s disease, and brain cancer.

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“…The particular importance is conferred upon distribution of heavy non-radioactive isotopes of hydrogen ( 2 H/ 1 H) and oxygen ( 18O/ 16 O) [4]. At the same time the attention of scientists is often paid to study of isotopic composition in blood, urine and skin appendages [5][6][7][8], but distribution of isotopes in tissues of internal organs and its influence on growth and development of future generations is not sufficiently studied.…”

Section: Introductionmentioning

confidence: 99%

Change of 2H/1H Ratio and Adaptive Potential in Living Systems under Formation of Isotope Gradient

Джимак

Fedulova

Моисеев

et al. 2019

J. Pharm. Nutr. Sci.

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This article presents data on ability of drinking water with depleted concentrations of deuterium (deuterim depleted water – DDW, ?2H = -762 ‰) to influence on the adaptive capacities and functional activity of rats organism during long period of DDW consumption. The obtained data confirms the favorable effect of reduced ?2H on hepatocytes of medium and shows significant (by 10%) increase of body weight among rats which consumed DDW for 3 weeks after birth. It is also shown that when rats consumed DDW, the non-uniform distribution of deuterium in the blood plasma and liver, kidney and heart tissues is observed. At the same time under natural conditions ?2H was significantly lower in blood plasma than in tissues of internal organs (?2H plasma > ?2H of tissues of internal organs), whereas DDW consumption resulted in more significant decrease of ?2H level in blood plasma than in the internal organs, which phenomena was accompanied by change of direction of 2H/1H isotope gradient: ?2H of plasma < ?2H of tissue of internal organs. Stable change in direction of 2H/1H isotope gradient over 3 weeks is expressed by lower rate of weight gain in the first generation of rats. All these facts can be caused by influence of 2H/1H isotope gradient on long-term adaptation mechanisms, but not on short-term adaptation reactions. Decrease of ?2H in blood plasma and tissues of internal organs increases to a greater extent the resistance of an organism to influence of unfavorable environmental factors among future generations of rats consuming DDW for a long time.

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Applications of deuterium oxide in human health

Cited by 13 publications

References 92 publications

Comparison of body composition analysis methods among centenary women: Seeking simpler methods

Comparison of body composition analysis methods among centenary women: Seeking simpler methods

Possible Mechanisms of Biological Effects Observed in Living Systems during 2H/1H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes

Change of 2H/1H Ratio and Adaptive Potential in Living Systems under Formation of Isotope Gradient

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