Applications of Coumarins as Cardiovascular and Anti-Cancer Agents: A Short Review

Shejwalkar, Pushkar

doi:10.19080/jocct.2017.08.555749

Cited by 4 publications

(2 citation statements)

References 31 publications

(37 reference statements)

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“…Their role as secondary metabolites is to the protect from the herbivores, microorganisms and infection via antioxidative and enzyme inhibitory activities [156]. Numerous scientific studies have demonstrated miscellaneous pharmacological effects of coumarins, including antioxidative, cardioprotective, anti-inflammatory and anticancer activities [157,159]. The latter arises from their ability to inhibit the protein kinase and telomerase, induce a caspase-mediating apoptosis and exert an anti-angiogenic effect, as discussed by Önder [156].…”

Section: Coumarinsmentioning

confidence: 99%

Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

et al. 2022

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Since the middle of the last century, marine organisms have been identified as producers of chemically and biologically diverse secondary metabolites which have exerted various biological activities including anticancer, anti-inflammatory, antioxidant, antimicrobial, antifouling and others. This review primarily focuses on the marine phenolic compounds and their derivatives with potent anticancer activity, isolated and/or modified in the last decade. Reports on the elucidation of their structures as well as biosynthetic studies and total synthesis are also covered. Presented phenolic compounds inhibited cancer cells proliferation or migration, at sub-micromolar or nanomolar concentrations (lamellarins D (37), M (38), K (39), aspergiolide B (41), fradimycin B (62), makulavamine J (66), mayamycin (69), N-acetyl-N-demethylmayamycin (70) or norhierridin B (75)). In addition, they exhibited anticancer properties by a diverse biological mechanism including induction of apoptosis or inhibition of cell migration and invasive potential. Finally, phlorotannins 1–7 and bromophenols 12–29 represent the most researched phenolic compounds, of which the former are recognized as protective agents against UVB or gamma radiation-induced skin damages. Finally, phenolic metabolites were assorted into six main classes: phlorotannins, bromophenols, flavonoids, coumarins, terpenophenolics, quinones and hydroquinones. The derivatives that could not be attributed to any of the above-mentioned classes were grouped in a separate class named miscellaneous compounds.

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Section: Coumarinsmentioning

confidence: 99%

Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

et al. 2022

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“…antitumor [33], anticonvulsant , antipsychotic, analgesic, and antiviral activities [34]. This work aimed to explore a coumarin-based scaffold with multi-biomedical activities.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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The incidence of many human disorders, such as cancer, oxidative stress, diabetes mellitus, and inflammatory diseases, has been mountingly increased because of many factors, including environmental pollution, static lifestyle, and unhealthy feeding. In an attempt to explore a scaffold with multiple biomedical activities, four natural phenolic acids, namely vanillic-, protocatechuic-, ferulic-, and caffeic-acid, were selected to construct twelve derived coumarins. The skeletal formulas of the semi-synthesized coumarins were confirmed by analyzing their spectra afforded via various spectrophotometers. The biomedical characteristics of these coumarins were investigated and included their antioxidant, anti-inflammatory, antidiabetic, and anticancer activities. The antioxidant activity was quantified by monitoring the potential of these coumarins to reduce DPPH and hydroxyl oxidants and provide an electron in the redox reaction. The anti-inflammatory activity was detected by specifying the inhibitory and selectivity of these coumarins on two COX isozymes. The antidiabetic activity was determined by examining the capacity of these coumarins to suppress two enzymes involved in blood glucose regulation. The anticancer activity and cytotoxicity were examined via MTT-based methodology versus four cancer cell lines and one normal cell line. The findings revealed that the semi-synthesized coumarins exhibited potent antioxidant and anticancer activities with low-induced cytotoxicity. Also, these coumarins showed modest antidiabetic potential and inhibitory effects versus the COX isozymes, with some selectivity toward the inhibition of COX-2. The authors concluded that these coumarins, specifically YC11, provide a valid structural template for synthesizing multi-functional agents effective in treating health situations in which oxidative stress, inflammation, diabetes, and cancer are combined.

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Synthesis, in silico analysis, and biomedical effects of coumarins derived from resveratrol

Mustafa

2023

Phytomedicine Plus

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Applications of Coumarins as Cardiovascular and Anti-Cancer Agents: A Short Review

Cited by 4 publications

References 31 publications

Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

Anticancer Activities of Marine-Derived Phenolic Compounds and Their Derivatives

Untitled

Synthesis, in silico analysis, and biomedical effects of coumarins derived from resveratrol

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