Applications of coordination compounds having Schiff bases: A review

Sharma, Jyoti; Dogra, Pernita; Sharma, Nadeem; Ajay, Ajay

doi:10.1063/1.5122381

Cited by 6 publications

(11 citation statements)

References 42 publications

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“…In brief, GUDF was prepared in DMSO solvent by using standardized steps including vortexing, centrifugation, and filtration by 0.45-micron syringe filter membrane to ensure that GUDF is sterile and compatible with cell culture. This was adopted from a previously published procedure by our lab [43][44][45][46]. Next, treatment by GUDF and DMSO control was allowed for 72 h. At the end of incubation, HCT-116 cells were harvested with the help of a routine procedure and evaluated for loss of proliferation and viability due to GUDF by using a Trypan blue dye exclusion assay.…”

Section: Preparation Of Extracellular Conditioned Mediummentioning

confidence: 99%

“…However, the importance of this paper is an extension to the previous observations by exploring metabolites in the extracellular conditioned medium of HCT-116 cells treated by GUDF. Therefore, the extracellular conditioned medium of GUDF and DMSO-treated HCT-116 cells were collected in separate sterile tubes and processed by centrifugation to ensure that viable and dead cells are not left in the tube so that only the extracellular nature of metabolites will be analyzed [43][44][45][46].…”

Section: Preparation Of Extracellular Conditioned Mediummentioning

confidence: 99%

“…The fractionated extracellular metabolites were collected in the running buffer (96 mM glycine of pH at 8.3). The detailed procedure was adopted from previously published inhouse VTGE-assisted purification of metabolites [44,43,45,46]. Furthermore, LC-HRMS analyses of VTGEpurified extracellular metabolite elutes were performed by Agilent TOF/Q-TOF Mass Spectrometer station Dual AJS ESI ion source.…”

Section: Extracellular Metabolite Profilingmentioning

confidence: 99%

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Secretion of Sphinganine by Drug-Induced Cancer Cells and Modified Mimetic Sphinganine (MMS) as c-Src Kinase Inhibitor

Nandangiri,

T N,

Raj

et al. 2024

Asian Pac J Cancer Prev

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Background: Cancer cells exhibit selective metabolic reprogramming to promote proliferation, invasiveness, and metastasis. Sphingolipids such as sphingosine and sphinganine have been reported to modulate cell death processes in cancer cells. However, the potential of extracellular sphinganine and its mimetic compounds as inducers of cancer cell death has not been thoroughly investigated. Methods: We obtained extracellular conditioned medium from HCT-116 cells treated with the previously reported anticancer composition, goat urine DMSO fraction (GUDF). The extracellular metabolites were purified using a novel and in-house developed vertical tube gel electrophoresis (VTGE) technique and identified through LC-HRMS. Extracellular metabolites such as sphinganine, sphingosine, C16 sphinganine, and phytosphingosine were screened for their inhibitory role against intracellular kinases using molecular docking. Molecular dynamics (MD) simulations were performed to study the inhibitory potential of a novel designed modified mimetic sphinganine (MMS) (Pubchem CID: 162625115) upon c-Src kinase. Furthermore, inhibitory potential and ADME profile of MMS was compared with luteolin, a known c-Src kinase inhibitor. Results: Data showed accumulation of sphinganine and other sphingolipids such as C16 sphinganine, phytosphingosine, and ceramide (d18:1/14:0) in the extracellular compartment of GUDF-treated HCT-116 cells. Molecular docking projected c-Src kinase as an inhibitory target of sphinganine. MD simulations projected MMS with strong (-7.1 kcal/mol) and specific (MET341, ASP404) binding to the inhibitory pocket of c-Src kinase. The projected MMS showed comparable inhibitory role and acceptable ADME profile over known inhibitors. Conclusion: In summary, our findings highlight the significance of extracellular sphinganine and other sphingolipids, including C16 sphinganine, phytosphingosine, and ceramide (d18:1/14:0), in the context of drug-induced cell death in HCT-116 cancer cells. Furthermore, we demonstrated the importance of extracellular sphinganine and its modified mimetic sphinganine (MMS) as a potential inhibitor of c-Src kinase. These findings suggest that MMS holds promise for future applications in targeted and combinatorial anticancer therapy.

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Section: Preparation Of Extracellular Conditioned Mediummentioning

confidence: 99%

Section: Preparation Of Extracellular Conditioned Mediummentioning

confidence: 99%

Section: Extracellular Metabolite Profilingmentioning

confidence: 99%

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Secretion of Sphinganine by Drug-Induced Cancer Cells and Modified Mimetic Sphinganine (MMS) as c-Src Kinase Inhibitor

Nandangiri,

T N,

Raj

et al. 2024

Asian Pac J Cancer Prev

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“…Сульфазин активно использовался для лечения грамположительных и грамотрицательных бактериальных инфекций, а также при токсоплазмозе и в комплексном лечении лекарственноустойчивых форм малярии. Биодоступность сульфазина в виде пероральных лекарственных форм составляет около 80 % [41]. Что касается сульфадимезина, то он также обладает широким антимикробным спектром биологической активности.…”

Section: противомикробная антигрибковая и противопаразитарная активностьunclassified

Review of Pyrimidine Derivatives as Pharmacologically Active Compounds

Chiriapkin

2022

Juvenis scientia

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Pyrimidine derivatives represent an extensive class of organic compounds that contain in their structure a six-membered heterocycle with two nitrogen atoms at positions 1 and 3. Substances of this group have a wide range of pharmacological activity, which makes it possible to consider the pyrimidine core as a promising scaffold for the development of new biologically active compounds. The article provides an analysis of the literature data of pyrimidine derivatives used in medical practice. For example, there are substances with antiviral, psychotropic, antimicrobial, antitumor, antifungal, antiparasitic and anabolic activity. Based on the structure-activity relationship of pyrimidine structures of active drugs, as well as other compounds that are considered candidates for the development of new drugs, it is possible to search for and design compounds with the desired types of pharmacological activity. Thus, a systematic analysis of pyrimidine derivatives from a pharmacological point of view can serve as a basis for further search for new highly effective and safe medicines.

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“…The latest power distribution system is fetching very susceptible to the various PQ (Power-Quality) problems [1]. PQ in distribution systems is a focal concern for industrial, commercial and residential purposes.…”

Section: Introductionmentioning

confidence: 99%

Esa Based Upqc Controller to Improve Power Quality in Microgrid System

Rao,

Sowjanya,

Rao

et al. 2019

IJEAT

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Generally, Power Quality is the main concern parameter in present power system scenario, the main causes for effecting the power quality is due to either harmonic distortion, voltage imbalances, reactive power variations. There are many techniques applied to maintain this power quality in literature. In Facts family, the UPQC controller plays a key role, because it uniquely controls all the transmission parameters. The UPQC controller is combination of series-shunt converters with common dc link. The signals required for these converters are generated by reference and actual signals of bus and dc link capacitor. Phase locked loop helps to provide the phase angle sequence required to improve power factor. In addition with, this paper is implemented with extended search algorithm to better control the dc link voltage for improving power quality. Mat lab/Simulink is used to test the system conditions and performance.

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Applications of coordination compounds having Schiff bases: A review

Cited by 6 publications

References 42 publications

Secretion of Sphinganine by Drug-Induced Cancer Cells and Modified Mimetic Sphinganine (MMS) as c-Src Kinase Inhibitor

Secretion of Sphinganine by Drug-Induced Cancer Cells and Modified Mimetic Sphinganine (MMS) as c-Src Kinase Inhibitor

Review of Pyrimidine Derivatives as Pharmacologically Active Compounds

Esa Based Upqc Controller to Improve Power Quality in Microgrid System

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