Applications of chitin and chitosan nanofibers in bone regenerative engineering

Tao, Fenghua; Cheng, Yanxiang; Shi, Xiaowen; Zheng, Huifeng; Du, Yong; Wei, Xiang; Deng, Hongbing

doi:10.1016/j.carbpol.2019.115658

Cited by 238 publications

(132 citation statements)

References 162 publications

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“…This systematic review aimed to obtain an up-to-date overview of the usage and efficacy of chitosan-based scaffold used alone or combined with other biomaterials, (whose characteristics and properties are shown in Tables 7 and 8), molecules, and cellular components. Thanks to its multiple properties, CS has been used for years in periodontal regeneration techniques [42][43][44][45][46]; the analysis of the most recent literature conducted in our paper highlighted that this biomaterial might be combined with other natural-or synthetic-based polymers obtaining bi-and trilayered scaffolds, which allow the simultaneous regeneration of the different tissues of the periodontal apparatus [21,25]. This capacity clarifies the reason why CS-based scaffolds should be used in the field of periodontal tissue engineering.…”

Section: Discussionsupporting

confidence: 52%

Nanomaterials for Periodontal Tissue Engineering: Chitosan-Based Scaffolds. A Systematic Review

et al. 2020

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Introduction. Several biomaterials are used in periodontal tissue engineering in order to obtain a three-dimensional scaffold, which could enhance the oral bone regeneration. These novel biomaterials, when placed in the affected area, activate a cascade of events, inducing regenerative cellular responses, and replacing the missing tissue. Natural and synthetic polymers can be used alone or in combination with other biomaterials, growth factors, and stem cells. Natural-based polymer chitosan is widely used in periodontal tissue engineering. It presents biodegradability, biocompatibility, and biological renewability properties. It is bacteriostatic and nontoxic and has hemostatic and mucoadhesive capacity. The aim of this systematic review is to obtain an updated overview of the utilization and effectiveness of chitosan-based scaffold (CS-bs) in the alveolar bone regeneration process. Materials and Methods. During database searching (using PubMed, Cochrane Library, and CINAHL), 72 items were found. The title, abstract, and full text of each study were carefully analyzed and only 22 articles were selected. Thirteen articles were excluded based on their title, five after reading the abstract, twenty-six after reading the full text, and six were not considered because of their publication date (prior to 2010). Quality assessment and data extraction were performed in the twelve included randomized controlled trials. Data concerning cell proliferation and viability (CPV), mineralization level (M), and alkaline phosphatase activity (ALPA) were recorded from each article Results. All the included trials tested CS-bs that were combined with other biomaterials (such as hydroxyapatite, alginate, polylactic-co-glycolic acid, polycaprolactone), growth factors (basic fibroblast growth factor, bone morphogenetic protein) and/or stem cells (periodontal ligament stem cells, human jaw bone marrow-derived mesenchymal stem cells). Values about the proliferation of cementoblasts (CB) and periodontal ligament cells (PDLCs), the activity of alkaline phosphatase, and the mineralization level determined by pure chitosan scaffolds resulted in lower than those caused by chitosan-based scaffolds combined with other molecules and biomaterials. Conclusions. A higher periodontal regenerative potential was recorded in the case of CS-based scaffolds combined with other polymeric biomaterials and bioceramics (bio compared to those provided by CS alone. Furthermore, literature demonstrated that the addition of growth factors and stem cells to CS-based scaffolds might improve the biological properties of chitosan.

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Section: Discussionsupporting

confidence: 52%

Nanomaterials for Periodontal Tissue Engineering: Chitosan-Based Scaffolds. A Systematic Review

et al. 2020

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“…Several research projects have been carried out about the biocompatibility of both natural and synthetic electrospun polymers [149][150][151]. Among the first, chitosan [152], collagen [153], gelatin [154] or cellulose [155] have been widely explored in tissue engineering due to their bio-based origin, renewability, biocompatibility and biodegradability. Synthetic polymers such as poly (ε-caprolactone) (PCL) or PVA are among the most studied especially because they are easy to electrospun and present good mechanical properties [156,157].…”

Section: Advanced Smart Propertiesmentioning

confidence: 99%

Potential Applications of Magnesium-Based Polymeric Nanocomposites Obtained by Electrospinning Technique

et al. 2020

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In the last few decades, the development of new electrospun materials with different morphologies and advanced multifunctional properties are strongly consolidated. There are several reviews that describe the processing, use and characterization of electrospun nanocomposites, however, based on our knowledge, no review on electrospun nanocomposites reinforced with nanoparticles (NPs) based on magnesium, Mg-based NPs, are reported. Therefore, in the present review, we focus attention on the fabrication of these promising electrospun materials and their potential applications. Firstly, the electrospinning technique and its main processing window-parameters are described, as well as some post-processing methods used to obtain Mg-based materials. Then, the applications of Mg-based electrospun nanocomposites in different fields are pointed out, thus taking into account the current trend in developing inorganic-organic nanocomposites to gradually satisfy the challenges that the industry generates. Mg-based electrospun nanocomposites are becoming an attractive field of research for environmental remediation (waste-water cleaning and air filtration) as well as for novel technical textiles. However, the mayor application of Mg-based electrospun materials is in the biomedical field, as pointed out. Therefore, this review aims to clarify the tendency in using electrospinning technique and Mg-based nanoparticles to huge development at industrial level in the near future.

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“…According to the structure and composition of natural bone, natural macromolecule/HAP composite scaffolds synthesized by biomimetic mineralization with natural bioactive macromolecules are currently key research focuses in this field [ 59 , 106 , 107 ]. Among these macromolecules, chitosan is a popular alternative because of its excellent biological properties [ 108 ].…”

Section: Applications Of Chitosan-based Biomimetically Mineralizedmentioning

confidence: 99%

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Ren

et al. 2020

Molecules

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Chitosan is a natural, biodegradable cationic polysaccharide, which has a similar chemical structure and similar biological behaviors to the components of the extracellular matrix in the biomineralization process of teeth or bone. Its excellent biocompatibility, biodegradability, and polyelectrolyte action make it a suitable organic template, which, combined with biomimetic mineralization technology, can be used to develop organic-inorganic composite materials for hard tissue repair. In recent years, various chitosan-based biomimetic organic-inorganic composite materials have been applied in the field of bone tissue engineering and enamel or dentin biomimetic repair in different forms (hydrogels, fibers, porous scaffolds, microspheres, etc.), and the inorganic components of the composites are usually biogenic minerals, such as hydroxyapatite, other calcium phosphate phases, or silica. These composites have good mechanical properties, biocompatibility, bioactivity, osteogenic potential, and other biological properties and are thus considered as promising novel materials for repairing the defects of hard tissue. This review is mainly focused on the properties and preparations of biomimetically mineralized composite materials using chitosan as an organic template, and the current application of various chitosan-based biomimetically mineralized composite materials in bone tissue engineering and dental hard tissue repair is summarized.

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Applications of chitin and chitosan nanofibers in bone regenerative engineering

Cited by 238 publications

References 162 publications

Nanomaterials for Periodontal Tissue Engineering: Chitosan-Based Scaffolds. A Systematic Review

Nanomaterials for Periodontal Tissue Engineering: Chitosan-Based Scaffolds. A Systematic Review

Potential Applications of Magnesium-Based Polymeric Nanocomposites Obtained by Electrospinning Technique

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

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