Applications of Calixarenes as Potential Ionophores for Electrochemical Sensors

Nashar, Rasha M. El; Wagdy, Hebatallah A.; Aboul‐Enein, Hassan Y.

doi:10.2174/157341109788680273

Cited by 23 publications

(10 citation statements)

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“…This issue can be resolved by measuring the intensity of both beams, probe beam and diffracted beam simultaneously, by the incorporation of a low-cost beam splitter. The two ionophores used in this article have been widely used in the fabrication of ion-selective electrodes for potentiometric measurements [ 12 , 13 , 14 ]. Ion-selective potentiometry is a popular electro-analytical method [ 15 , 16 ] and there are a number of applications which include, but are not limited to the detection of ions in water or other media.…”

Section: Introductionmentioning

confidence: 99%

Modified Surface Relief Layer Created by Holographic Lithography: Application to Selective Sodium and Potassium Sensing

Gul

O’Neill

Cassidy

et al. 2019

Sensors

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Point-of-care diagnostics will rely upon the development of low-cost, noncomplex, and easily integrated systems in order to examine biological samples such as blood and urine obtained from the patient. The development of metal ion sensors is a subject of significant relevance for physiological samples. The level of different blood electrolytes, mainly H+, Na+, K+ and Cl− is considerably used to monitor irregular physiologies. The particular challenge in biosensing, and in fact for any other sensor, is signal differentiation between non-specifically bound material and the specific detecting of the target molecule/ion. The biosensors described in this paper are fabricated by a holographic recording of surface relief structures in a photopolymer material. The surface structures are modified by coating with either dibenzo-18-crown-6 (DC) or tetraethyl 4-tert-butylcalix[4]arene (TBC), which are embedded in a polymer matrix. Interrogation of these structures by light allows indirect measurement of the concentration of the analyte. The influence of polymer matrices with different porosities, plasticised polyvinyl chloride (PVC) and a sol-gel matrix, on the performance of the sensors for detection of K+ and Na+ is examined. Here we demonstrate a proof of concept that by using a matrix with higher porosity one can increase the sensitivity of the sensor. The results showed that the DC sensing layer provides a selective response to K+ over Na+ and the TBC modified grating is more responsive to Na+ over K+. The sensor responds to K+ and Na+ within the physiological concentration ranges.

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Section: Introductionmentioning

confidence: 99%

Modified Surface Relief Layer Created by Holographic Lithography: Application to Selective Sodium and Potassium Sensing

Gul

O’Neill

Cassidy

et al. 2019

Sensors

View full text Add to dashboard Cite

show abstract

“…Interrogation of these structures by light allows indirect measurements of chemical analytes' concentration in real time. These two ionophores have been previously widely used in the fabrication of ion selective electrode for potentiometric measurements [5][6] [7].…”

Section: Introductionmentioning

confidence: 99%

Development of sensitive holographic devices for physiological metal ion detection

Gul¹,

Martin²,

Cassidy³

et al. 2017

Nanoengineering: Fabrication, Properties, Optics, and Devices XIV

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The development of selective alkali metal ions sensors in particular is a subject of significant interest. In this respect, the level of blood electrolytes, particularly H + , Na + , K + and Cl -, is widely used to monitor aberrant physiologies associated with pulmonary emphysema, acute and chronic renal failure, heart failure, diabetes. The sensors reported in this paper are created by holographic recording of surface relief structures in a self-processing photopolymer material. The structures are functionalized by ionophores dibenzo-18-crown-6 (DC) and tetraethyl 4-tert-butylcalix[4]arene (TBC) in plasticised polyvinyl chloride (PVC) matrix. Interrogation of these structures by light allows indirect measurements of chemical analytes' concentration in real time. We present results on the optimisation and testing of the holographic sensor. A self-processing acrylamide-based photopolymer was used to fabricate the required photonic structures. The performance of the sensors for detection of K + and Na + was investigated. It was observed that the functionalisation with DC provides a selective response of the devices to K + over Na + and TBC coated surface structures are selectively sensitive to Na + . The sensor responds to Na + within the physiological ranges. Normal levels of Na + and K + in human serum lie within the ranges 135-148mM and 3.5-5.3 mM respectively.

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“…25, No. 1 (2013), [1][2][3][4][5][6][7][8][9][10][11][12] http://dx.doi.org/10.14233/ajchem.2013.12058A in sensor chemistry. The applications of calixarene derivatives in five main fields of potentiometry, voltammetry, luminescent, colorimetric and miscellaneous techniques are reviewed.…”

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confidence: 99%

“…Potentiometric sensors: Potentiometric sensors are reviewed in this section, followed by the researches conducted by the calixarenes complexes. El Nashar et al 10 reviewed pharmaceutical and biological applications of calixarenes using potentiometric sensors from 2001 up to 2009. Zine et al 11 described potassium-ion selective microelectrodes with calix [4]crown-5 ionophore and linear response range of 6 × 10 -6 to 1 × 10 -1 M and detection limit of 1.8 × 10 -6 M. Gupta et al 12 evaluated an ionophore for the analysis of Sr 2+ by a carboxy methoxy calix [6]arene derivative.…”

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Application of Calixarenes in Development of Sensors

Bahram¹,

Pourabdollah²

2013

Asian J. Chem.

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Calixarenes, were introduced in 1870 for the first time but were ignored until 1940. In 1970s they were studied with uncertainty. During 1990 they were presented in brief out line with an emphasize on the use of these molecules for chemical separations. Finally, the discovery of calixarenes was attributed to Zinke (1940) and fully interpreted by Gutsche in 1970. Gutsche was also the first to draw attention to the potential use of them as molecular receptors or enzyme mimics. He proposed that these cyclic oligomers, known as collectively calixarenes in 1978, having recognized in space-filling models of the tetramer a chalice or cup-like shape reminiscent of a Greek crater vase. Baldini et al. 1 in their review paper, illustrated the conformations of calixarenes including: cone, partial cone, 1,2-alternate and 1,3-alternate. Various methods for functionalizing calixarenes have been developed and numerous calixarene derivatives have been synthesized during the past two decades. Various applications of calixarenes are used in purification, chromatography, catalysis, enzyme mimics, ion selective electrodes, phase transfer, transport across membranes, ion channels and self-assembling monolayers 2. Calixarenes have demonstrated outstanding complex ability towards ions, neutral molecules, etc. and are considered as the third best host molecules after cyclodextrins and crown ethers 3. During the last three decades calixarene chromoionophores have long

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Applications of Calixarenes as Potential Ionophores for Electrochemical Sensors

Cited by 23 publications

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Modified Surface Relief Layer Created by Holographic Lithography: Application to Selective Sodium and Potassium Sensing

Modified Surface Relief Layer Created by Holographic Lithography: Application to Selective Sodium and Potassium Sensing

Development of sensitive holographic devices for physiological metal ion detection

Application of Calixarenes in Development of Sensors

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