Applications of biotechnology and genomics in goats

Barrera-Saldaña, Hugo A.; Ascacio-Martínez, Jorge A.; Sifuentes‐Rincón, Ana María; Arellano-Vera, Williams; Arbiza, S.I.

doi:10.1016/j.smallrumres.2009.12.030

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…The GH is released into systemic circulation and causes the secretion of the insulin like growth factor – 1 (IGF-1) in target tissues, it also causes a series of direct metabolic effects as it is both hyperglycaemic and lipolytic (Polkowska et al 2011). As a consequence, the growth hormone is directly involved in animal processes such as metabolism (Barrera-Saldaña et al 2010), growth (Hua et al 2009), reproduction (Scaramuzzi et al 1999) and lactation (Baldi, 1999).…”

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confidence: 99%

Growth hormone gene variability and its effects on milk traits in primiparous Sarda goats

Dettori

Rocchigiani

Luridiana

et al. 2013

Journal of Dairy Research

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The aim of this research was to investigate variability in each of the five exons of the caprine growth hormone (gGH) gene, in order to establish the possible relationships with milk traits in Sarda breed goat. The general linear model procedure was used to analyse the effects of the single strand conformation (SSCP) profiles on milk traits of 100 lactating goats. Analysis of conformational polymorphism at exons 1-5 revealed a total of 25 differing banding patterns. Sequencing revealed 21 nucleotide changes (compared with GenBank D00476): 14 were polymorphic and 7 monomorphic; 19 in exonic regions, 5 of which were nonsynonymous. A SNP upstream of the transcription initiation codon (c.-3A>G) and an indel (c.*29_30insC) in the 3'UTR, were detected. Alignment of 4 cloned sequences including the entire gGH gene led to the identification of 22 nucleotide variations within the intron regions, including two indels. Association analysis revealed that each exon, except exon-1, affected milk yield, exons 1 and 3 influenced milk fat percentage, and all exons, except exon-2, had an effect on protein percentage, supporting previous results in livestock. The variability detected at the caprine GH gene might provide useful information for the phylogeny of ruminants and, more importantly, have implications on the biological function of the growth hormone and on those traits resulting from its physiological action, including milk production and composition. The caprine GH gene may become a useful molecular marker for a more effective genetic selection for milk production traits in goats.

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mentioning

confidence: 99%

Growth hormone gene variability and its effects on milk traits in primiparous Sarda goats

Dettori

Rocchigiani

Luridiana

et al. 2013

Journal of Dairy Research

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“…As a result of these physiological effects, GH is considered a candidate gene for marker-assisted selection in livestock [5][6][7]. The bovine growth hormone (GH) gene (Gen Bank Acc.…”

Section: Introductionmentioning

confidence: 99%

“…It plays an important role in growth, lactation, milk production, reproduction processes, protein, lipid and carbohydrate metabolism [ 1 , 2 , 3 , 4 ]. As a result of these physiological effects, GH is considered a candidate gene for marker-assisted selection in livestock [ 5 , 6 , 7 ]. The bovine growth hormone ( GH ) gene (Gen Bank Acc.…”

Section: Introductionmentioning

confidence: 99%

Effect of GH p.L127V Polymorphism and Feeding Systems on Milk Production Traits and Fatty Acid Composition in Modicana Cows

Bordonaro

Tumino

Marletta

et al. 2020

Animals

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Growth hormone participates in the regulation of lactation and lipid metabolism. A trial study was conducted to evaluate the effects of genetic polymorphism at GH p.L127V and its interaction with feeding system (extensive, EX; semi-intensive, SI) on milk traits and fatty acids composition in Modicana cows. In the semi-intensive farm (SI) diet consisted of hay, concentrate and 2 h of grazing. In the extensive farm (EX) feeding consisted in 8 h of grazing and hay. The frequencies of LL, LV and VV genotypes were, respectively: 0.64, 0.34, 0.02. GH polymorphism and its interaction with feeding system did not influence milk yield and composition. Cows carrying LL genotype produced milk with lower 6:0 and 8:0 and higher 16:1 c9 and 18:1 c9, total UFA and total MUFA. Feeding significantly affected fatty acids: in EX cows lower SFA and higher PUFA and UFA were found, compared to SI cows. The lower, more favorable atherogenic index of milk from EX system was coherent with the improved healthy characteristics of milk from animals fed almost exclusively on pasture. A significant interaction genotype x feeding system was evident for 18:1, higher in the LL cows only in the EX system, but not in the SI system.

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Genetic diversity of South African dairy goats for genetic management and improvement

Bosman

Marle-Köster

Visser

2015

Small Ruminant Research

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Highlights• 240 dairy goats from three breeds were genotyped using 25 microsatellite markers.• Moderate to high levels of genetic diversity was observed in all breeds.• Limited inbreeding was indicated by F IS values.• Populations clustered into three breeds and a crossbred population cluster.• Uncontrolled cross breeding should be avoided to maintain breed integrity. AbstractThe dairy goat industry is a small, but important role player in the South African agricultural sector. The limited number of animals representing the three main breeds (Saanen, British Alpine and Toggenburg) has raised concerns over the genetic diversity of these animals and the impact on their genetic management. In this study 240 dairy goats representing three breeds were genotyped with 25 microsatellite markers. Sufficient levels of genetic diversity were observed in all the breeds, with observed heterozygosity values exceeding 60%. A slight population differentiation was indicated by the low F ST values across and within the populations. This was confirmed by the AMOVA analyses with most of the variation shown within populations (91.7%). Negative F IS values in the three breeds indicated limited inbreeding. Population structure analyses revealed six distinct groups, with the Saanen population clustering into three sub-groups. The Toggenburg and British Alpine breeds formed their own separate cluster, with a last cluster formed by animals from all three pure-bred populations, indicating high levels of admixture. These results caution farmers against uncontrolled crossbreeding practices and recommend routine evaluation of genetic diversity.

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Applications of biotechnology and genomics in goats

Cited by 3 publications

References 35 publications

Growth hormone gene variability and its effects on milk traits in primiparous Sarda goats

Growth hormone gene variability and its effects on milk traits in primiparous Sarda goats

Effect of GH p.L127V Polymorphism and Feeding Systems on Milk Production Traits and Fatty Acid Composition in Modicana Cows

Genetic diversity of South African dairy goats for genetic management and improvement

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