Applications of bioluminescence in biotechnology and beyond

Syed, Aisha J; Anderson, James C.

doi:10.1039/d0cs01492c

Cited by 154 publications

(117 citation statements)

References 371 publications

(390 reference statements)

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“…Oxidation of the luciferin diphenyterazine (DTZ) by Antares2 leads to orange-red light emission, rather than the blue light emitted by teLuc alone, due to bioluminescent energy transfer (BRET) of the energy of DTZ oxidation to the fluorophores of the CyOFP1 moieties. This is pronounced shift in the wavelength of emitted light is critical to the detection of functional mRNA delivery in vivo, as the absorbance of tissues is inversely proportion to the wavelength of light (63).…”

Section: Creation Of Antares2 Mrna-loaded Exosomesmentioning

confidence: 99%

Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Tsai

Atai

Cacciottolo

et al. 2021

Journal of Biological Chemistry

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Creation Of Antares2 Mrna-loaded Exosomesmentioning

confidence: 99%

Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Tsai

Atai

Cacciottolo

et al. 2021

Journal of Biological Chemistry

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“…Various luciferases have been incorporated into a diverse array of cell types and long been used as reporter tools for tracking gene expression patterns and cell movements in research animals (Love and Prescher, 2020). The knowledge of all enzymes participating in bioluminescence cascades opens the possibility of engineering organisms with self-sustained luminescence, thus allowing the development of substrateindependent bioluminescence-based reporter technologies (Syed and Anderson, 2021). Apart from practical importance the exploration of luciferin biosynthetic pathways promotes our understanding of the origins and function of bioluminescence and provides new insights into ecological significance of this trait.…”

Section: Discussionmentioning

confidence: 99%

Luciferins Under Construction: A Review of Known Biosynthetic Pathways

Tsarkova

2021

Front. Ecol. Evol.

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Bioluminescence, or the ability of a living organism to generate visible light, occurs as a result of biochemical reaction where enzyme, known as a luciferase, catalyzes the oxidation of a small-molecule substrate, known as luciferin. This advantageous trait has independently evolved dozens of times, with current estimates ranging from the most conservative 40, based on the biochemical diversity found across bioluminescence systems (Haddock et al., 2010) to 100, taking into account the physiological mechanisms involved in the behavioral control of light production across a wide range of taxa (Davis et al., 2016; Verdes and Gruber, 2017; Bessho-Uehara et al., 2020a; Lau and Oakley, 2021). Chemical structures of ten biochemically unrelated luciferins and several luciferase gene families have been described; however, a full biochemical pathway leading to light emission has been elucidated only for two: bacterial and fungal bioluminescence systems. Although the recent years have been marked by extraordinary discoveries and promising breakthroughs in understanding the molecular basis of multiple bioluminescence systems, the mechanisms of luciferin biosynthesis for many organisms remain almost entirely unknown. This article seeks to provide a succinct overview of currently known luciferins’ biosynthetic pathways.

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“…В настоящее время известно не менее десятка различных неапоптотических механизмов программируемой клеточной гибели, таких как аутофагия, некроптоз, ферроптоз, пироптоз, партанатоз, энтоз, нетоз и др. [ [10]. Такие системы широко распространены в природе, однако хорошо изучено и адаптировано для применения всего несколько.…”

Section: ферроптоз -новый вид программируемой клеточной гибелиunclassified

Perspektivy ispol'zovaniya biolyuminescentnoj sistemy Chaetopterus variopedatus dlya monitoringa ferroptoza v zhivyh organizmah

Щеглов¹,

Царькова²

2021

Вестник РГМУ

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Ferroptoz — osobyj tip programmiruemoj gibeli kletok, svyazannyj s intensivnym okisleniem lipidov pod dejstviem svobodnyh ionov dvuhvalentnogo zheleza. Novye induktory i supressory ferroptoza mogut stat' osnovoj dlya sozdaniya preparatov dlya lecheniya nejrodegenerativnyh i onkologicheskih zabolevanij. Dlya poiska takih induktorov (supressorov) ferroptoza neobhodimo detektirovat' etot process v zhivyh kletkah ili u laboratornyh zhivotnyh. Lyuciferaza (fotoprotein) morskogo drakona Chaetopterus variopedatus dlya svoej aktivnosti trebuet pomimo dvuh kofaktorov nalichiya ionov zheleza i peroksida vodoroda (libo organicheskih gidroperoksidov). Sootvetstvenno biolyuminescentnaya sistema morskogo drakona mozhet byt' ispol'zovana dlya monitoringa ferroptoza v zhivyh organizmah.

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Applications of bioluminescence in biotechnology and beyond

Abstract: Bioluminescent probes have hugely benefited from the input of synthetic chemistry and protein engineering. Here we review the latest applications of these probes in biotechnology and beyond, with an eye on current limitations and future directions.

Cited by 154 publications

References 371 publications

Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Luciferins Under Construction: A Review of Known Biosynthetic Pathways

Perspektivy ispol'zovaniya biolyuminescentnoj sistemy Chaetopterus variopedatus dlya monitoringa ferroptoza v zhivyh organizmah

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