Applications of a Single Molecule Theory of Protein Dynamics
Fang Yi
Abstract:A single molecule theory for protein dynamics has been developed since 2012. It consists of the concepts of conformational Gibbs free energy function (CGF) and single molecule thermodynamic hypothesis (STH) that claims that all stable conformations are (local or global) minimizers of CGF. These are enough to give a unified explanations and mechanisms to many aspects of protein dynamics such as protein folding; allostery; denaturation; and intrinsically disordered proteins. Formulas of CGF in water environment … Show more
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