Applications and safety of gold nanoparticles as therapeutic devices in clinical trials

Yao, Leeann; Bojic, Dejan; Liu, Mingyao

doi:10.1016/j.jpha.2023.06.001

Cited by 31 publications

(12 citation statements)

References 62 publications

(99 reference statements)

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“…CYT-6091 and NU-0129, phase I cleared AuNP based products, pre-clinically suggested detectable amounts of gold in the liver and tumor cells even after 120 or 174 days of treatment. 359 The pilot study with AuroLase™ in primary or metastatic lung cancer was terminated in 2014. 355 …”

Section: Clinically Developed Nano-gold Products: the Major Challenge...mentioning

confidence: 99%

Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy

Mal,

Chakraborty,

Mahapatra

et al. 2024

Nanoscale Adv.

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Section: Clinically Developed Nano-gold Products: the Major Challenge...mentioning

confidence: 99%

Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy

Mal,

Chakraborty,

Mahapatra

et al. 2024

Nanoscale Adv.

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“…The best AuNPs formulation has been evaluated in humans for drug delivery, as a therapeutic agent, and for photothermal therapy. 27,28 In these trials, it was reported that the AuNP formulations tested were safe, but the main concern centers on the fact that a portion of the gold is retained in the tumor tissues, and it is unknown what consequences there would be in the long term. 26–28 In contrast, the popular Turkevich method synthesizes AuNPs using sodium citrate as a reducing agent.…”

Section: Introductionmentioning

confidence: 99%

“…27,28 In these trials, it was reported that the AuNP formulations tested were safe, but the main concern centers on the fact that a portion of the gold is retained in the tumor tissues, and it is unknown what consequences there would be in the long term. 26–28 In contrast, the popular Turkevich method synthesizes AuNPs using sodium citrate as a reducing agent. However, removal of the byproducts of sodium citrate is required due to its potential toxicity.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled PHEA-based block copolymers for the synthesis of gold nanoparticles

Hermosillo-Ochoa,

Cortez-Lemus,

Reynoso-Soto

2024

New J. Chem.

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“…administration [ 24 ]. To address these problems, there are valid rationale and a strong need to absolutely reduce the dosage of nanomaterials via optimization of administration route capable of precise control of temperature in tumor tissues [ 25 ]. This has the great potential to trigger an outstanding antitumor immune response in the tumor microenvironment via mild PTT, achieving complete primary tumor regression and also preventing the growth of metastatic tumors by the abscopal effect while avoiding side effects within the body according to reduced material dosage [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Accurately Controlled Tumor Temperature with Silica-Coated Gold Nanorods for Optimal Immune Checkpoint Blockade Therapy

Yun,

Yang,

Shim

et al. 2024

Biomater Res

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Photothermal therapy (PTT) at mild temperatures ranging from 44 to 45 °C holds tremendous promise as a strategy for inducing potent immunogenic cell death (ICD) within tumor tissues, which can reverse the immunosuppressive tumor microenvironment (ITM) into an immune-responsive milieu. However, accurately and precisely controlling the tumor temperature remains a formidable challenge. Here, we report the precision photothermal immunotherapy by using silica-coated gold nanorods (AuNR@SiO 2 ), and investigating the optimal administration routes and treatment protocols, which enabled to achieve the sustained and controlled mild heating within the tumor tissues. First, the highest photothermal performance of AuNR@SiO 2 with 20-nm silica shell thickness than 5 or 40 nm was confirmed in vitro and in vivo. Then, the optimal conditions for precision immunotherapy were further investigated to produce mild temperature (44 to 45 °C) accurately in tumor tissues. The optimal conditions with AuNR@SiO 2 result in a distinct cell death with high early/late apoptosis and low necrosis, leading to very efficient ICD compared to lower or higher temperatures. In colon tumor-bearing mice, intratumorally injected AuNR@SiO 2 efficiently promotes a mild temperature within the tumor tissues by local irradiation of near-infrared (NIR) laser. This mild PTT substantially increases the population of mature dendritic cells (DCs) and cytotoxic T cells (CTLs) within tumor tissues, ultimately reversing the ITM into an immune-responsive milieu. Furthermore, we found that the combination mild PTT with AuNR@SiO 2 and anti-PD-L1 therapy could lead to the 100% complete regression of primary tumors and immunological memory to prevent tumor recurrence. Collectively, this study demonstrates that AuNR@SiO 2 with a robust methodology capable of continuously inducing mild temperature accurately within the ITM holds promise as an approach to achieve the precision photothermal immunotherapy.

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Applications and safety of gold nanoparticles as therapeutic devices in clinical trials

Cited by 31 publications

References 62 publications

Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy

Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy

Self-assembled PHEA-based block copolymers for the synthesis of gold nanoparticles

Accurately Controlled Tumor Temperature with Silica-Coated Gold Nanorods for Optimal Immune Checkpoint Blockade Therapy

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