Application value of D-dimer testing and Caprini risk assessment model (RAM) to predict venous thromboembolism (VTE) in Chinese non-oncological urological inpatients: a retrospective study from a tertiary hospital

Wu, Ziqiang; Li, Kaixuan; Zhu, Quan; Li, Hao-Zhen; Wang, Zhao

doi:10.21037/tau-20-320

Cited by 12 publications

(15 citation statements)

References 29 publications

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“…The results of this study showed that the level of D-dimer >1.25 mg/L was an independent risk factor. The critical value of D-dimer was much higher than previously reported (6,25). This difference may result from the high proportion of aged patients in this study.…”

Section: Discussioncontrasting

confidence: 74%

“…Thirty-day mortality of the VTE patients can reach more than 10-fold of the non-VTE patients (4) and about 30% of patients with PE die within the first year after diagnosis (5). Recent studies on VTE in urological non-oncological patients demonstrate that the incidence of VTE is not as rare as previously reported (6)(7)(8)(9). Few studies have been concerned about the incidence and risk factors of VTE in patients following TURP.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and Risk Factors of Venous Thromboembolism in Patients After Transurethral Resection of the Prostate (TURP)

Zheng

et al. 2022

Front. Surg.

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ObjectiveVenous thromboembolism (VTE) in patients following transurethral resection of the prostate (TURP) has been overlooked for many years. This research was aimed to investigate the incidence and risk factors of VTE in patients after TURP.MethodsA total of 451 patients who underwent TURP between January 2017 and December 2020 were retrospectively analyzed. Clinical data of the patients were collected, such as basic demographic data, prostate volume, creatinine values, hemoglobin values, surgery duration, Caprini score, international prostate symptom score (IPSS), quality of life (QOL) score, plasma D-dimer levels, and so on. Univariate analysis and multivariate logistic regression were performed to identify the potential risk factors of VTE. Venous ultrasonography of lower extremities was performed routinely to detect VTE for patients after TURP.ResultsIn total, 36 (8%) out of the 451 patients suffered from VTE. A total of 12 (2.7%) patients were confirmed with deep venous thrombosis (DVT). Two patients (0.4%) were identified with pulmonary embolism (PE). Twenty-two (4.9%) patients were suffered from superficial venous thrombosis. Furthermore, according to the results of multivariate stepwise logistic regression analysis, having a history of VTE (adjusted odds ratio [aOR] = 10.980, 95% CI = 2.265–53.223), complicated with postoperative bladder hematoma (aOR = 6.302, 95% CI = 2.265–17.532), D-dimer >1.25 mg/L (aOR = 4.402, 95% CI = 1.798–10.774), and age >65 (aOR = 3.106, 95% CI = 1.084–8.893) were independent risk factors of VTE after TURP. In addition, the nomogram prediction model is a useful auxiliary prevention tool of VTE.ConclusionThe incidence of VTE is severely underestimated in patients following TURP. A lot of asymptomatic VTEs have been overlooked. Early detection and diagnosis of VTE are essential. Nevertheless, further verifications based on the results of large-scaled studies are still needed.

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Section: Discussioncontrasting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Incidence and Risk Factors of Venous Thromboembolism in Patients After Transurethral Resection of the Prostate (TURP)

Zheng

et al. 2022

Front. Surg.

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“…The cutoff value for D-dimer was derived from our previous research. 8 The logistic regression model was built as . The probability model for predicting VTE was .…”

Section: Resultsmentioning

confidence: 99%

“…The cutoff value of the Caprini score was derived from our previous research. 8 The new model turned became and the probability model for predicting VTE became .…”

Section: Resultsmentioning

confidence: 99%

Establishment of Prediction Models for Venous Thromboembolism in Non-Oncological Urological Inpatients – A Single-Center Experience

Li¹,

Yu²,

Li³

et al. 2022

IJGM

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“…41 Some investigations also attempted to incorporate D-dimer results into Caprini RAM. 16,42,43 However, the efficacy of inclusion of D-dimer remains far from resolved, probably because in these studies, the optimal cutoff value of D-dimer level was independently acquired and was simply combined to risk models.…”

Section: Multivariate Regression Analysis Was Performed By Incorporatingmentioning

confidence: 99%

Validation of a modified Caprini risk assessment model in lung cancer patients undergoing surgery: Results of a multicenter cross‐sectional observational study

Cui

Yang

et al. 2022

Journal of Surgical Oncology

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Background and Objectives: Lung cancer patients slated for surgery are at high risk of venous thromboembolism (VTE). Precise risk assessment is necessary for providing proper thromboprophylaxis and reducing morbidity and mortality of VTE.Methods: A multicenter, observational, cross-sectional cohort study, involving patients with primary lung cancer undergoing surgery, was carried out from August 2016 to December 2019. All patients were assessed according to the Caprini risk assessment model (RAM) and a modified scoring system incorporating elevated Ddimer and new stratification of surgical time. The endpoint was confirmed VTE or patient discharge.Results: Out of 1205 patients, 87 (7.2%) were diagnosed with VTE. The area under the curve of modified scores for VTE was 0.759, which was larger than that of the original one (0.589) (p < 0.05). By modified Caprini scoring system, a higher score was associated with increased VTE risk (odds ratio [OR], 1.345; 95% confidence interval [CI],; p < 0.001), and there was an increased OR of 4.090 (95% CI, 2.472-6.768, p < 0.001) for VTE in high-risk category patients. Conclusion:Modified Caprini RAM showed an improved prediction of high-risk patients with an elevated likelihood of postoperative VTE compared to the original one.

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Application value of D-dimer testing and Caprini risk assessment model (RAM) to predict venous thromboembolism (VTE) in Chinese non-oncological urological inpatients: a retrospective study from a tertiary hospital

Abstract: Background:The Caprini risk assessment model (RAM) and D-dimer testing have been widely used in the prediction of venous thromboembolism (VTE). However, the clinical significance of these testing options are limited in non-oncological urological inpatients because of the low specificity.

Cited by 12 publications

References 29 publications

Incidence and Risk Factors of Venous Thromboembolism in Patients After Transurethral Resection of the Prostate (TURP)

Incidence and Risk Factors of Venous Thromboembolism in Patients After Transurethral Resection of the Prostate (TURP)

Establishment of Prediction Models for Venous Thromboembolism in Non-Oncological Urological Inpatients – A Single-Center Experience

Validation of a modified Caprini risk assessment model in lung cancer patients undergoing surgery: Results of a multicenter cross‐sectional observational study

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