Application prospective of nanoprobes with MRI and FI dual-modality imaging on breast cancer stem cells in tumor

Abstract

Breast cancer (BC) is a serious disease to threat lives of women. Numerous studies have proved that BC originates from cancer stem cells (CSCs). But at present, no one approach can quickly and simply identify breast cancer stem cells (BCSCs) in solid tumor. Nanotechnology is probably able to realize this goal. But in study process, scientists find it seems that nanomaterials with one modality, such as magnetic resonance imaging (MRI) or fluorescence imaging (FI), have their own advantages and drawbacks. They cannot meet practical requirements in clinic. The nanoprobe combined MRI with FI modality is a promising tool to accurately detect desired cells with low amount in tissue. In this work, we briefly describe the MRI and FI development history, analyze advantages and disadvantages of nanomaterials with single modality in cancer cell detection. Then the application development of nanomaterials with dual-modality in cancer field is discussed. Finally, the obstacles and prospective of dual-modal nanoparticles in detection field of BCSCs are also pointed out in order to speed up clinical applications of nanoprobes.

A literature review on multimodality molecular imaging nanoprobes for cancer detection

“…The quantum dots (QD) probes based on semiconductor quantum dots have been introduced by researchers, and its applications in biological systems was published in Nature magazine which, marked era arrival of fluorescence QD labeling biological molecules [92,93]. QD probes can specially label biomarkers on tumor cell surface and accurately label subtle sub-cellular structure.…”

“…QD probes can specially label biomarkers on tumor cell surface and accurately label subtle sub-cellular structure. Application of nanoprobes with MR imaging-Fluorescence imaging (MRI-FI) as dualmodality at the same time have displayed the spatial distribution of breast cancer stem cells (BCSCs) in solid tumors [93].…”

Development of Fluorescence/MR Dual-Modal Manganese-Nitrogen-Doped Carbon Nanosheets as An Efficient Contrast Agent for Targeted Ovarian Carcinoma Imaging

“…Among these imaging methods, MR imaging is a powerful technique for high spatially resolved visualization of the anatomic structure and function of soft tissues with a deep penetration, but it has the disadvantage of low sensitivity [8][9][10]. Fluorescence imaging, as a functional imaging method, could compensate the limitation of MR imaging for its low sensitivity in cellular and subcellular levels attributed to the inherent high sensitivity of fluorescence imaging [10][11][12]. Therefore, the combination of MRI and FL imaging renders a promising dual-modal imaging technique with complementary characteristics to improve the accuracy of tumor diagnosis [11][12][13].…”

“…Fluorescence imaging, as a functional imaging method, could compensate the limitation of MR imaging for its low sensitivity in cellular and subcellular levels attributed to the inherent high sensitivity of fluorescence imaging [10][11][12]. Therefore, the combination of MRI and FL imaging renders a promising dual-modal imaging technique with complementary characteristics to improve the accuracy of tumor diagnosis [11][12][13].…”

Biomedical Applications of Fluorescent and Magnetic Resonance Imaging Dual‐Modality Probes

“…Nowadays, FI/MRI dual‐modality probes have already been widely applied in biomedical research and clinical practice . These probes not only overcome the shortcomings of FI or MRI, but also have synergistic advantages (Table ) …”