Application Progress of Light-Emitting Diode for Photodynamic Therapy

Li, 林立 Lin; Buhong, 李步洪 Li

doi:10.3788/lop57.150001

Cited by 2 publications

(1 citation statement)

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“…However, due to individual differences, accurately adjusting the irradiance according to the shape and size of the lesion on an irregular surface is necessary to avoid damage to surrounding normal tissues and optimize the treatment, by adjusting the light dose according to the degree of local lesions. 12 Therefore, the light dose, including irradiance (mW∕cm 2 ) and radiance (J∕cm 2 ), is one of the most important factors during PDT, which is a highly localized treatment. 13,14 In practice, most clinical PDT researchers worldwide pay attention to the calculation or measurement of the delivered light dose on a lesion surface.…”

Section: Introductionmentioning

confidence: 99%

Irradiance uniformity optimization for a photodynamic therapy treatment device with 3D scanner

Wang

Kang

et al. 2021

J. Biomed. Opt.

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Significance: The light dose in photodynamic therapy (PDT) has a considerable influence on its treatment effect, and irradiance uniformity is an issue of much concern for researchers. However, achieving intelligent and personalized dosimetry adjustments remains a challenge for current PDT instruments.Aim: To meet the requirements of intelligent and personalized dosimetry adjustments for the light dose on an irregular surface, a new PDT device with its optimal control method is proposed.Approach: This research introduces a new PDT device that includes a 3D scanner, a light-emitting diode (LED) array, and a computer. The 3D scanner is proposed to generate the point cloud of the lesion and the LED array light source, and obtain the relative position and rotation parameters between them. Then, an image segmentation algorithm is used to segment the lesion point cloud into several cluster regions. Last, the current of each LED unit is adjusted separately to achieve the expected irradiance on each cluster.Results: Compared with the general light source, the optimized light source increases the effective irradiance area by 9% to 15% and improves its uniformity by ∼9% on a human port-wine stain head model. Conclusions:The device and its optimal method may be used for optimizing the light dosimetry to realize intelligent and personalized treatment.

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Section: Introductionmentioning

confidence: 99%