Application of Yb,Er:Glass laser radiation for active drug delivery at the treatment of onychomycosis

Беликов, А. В.; Tavalinskaya, Anastasia D.; Smirnov, S. N.; Sergeev, A. N.

doi:10.18287/jbpe19.05.010305

Cited by 6 publications

(5 citation statements)

References 22 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Drug delivery through microchannels into the nail can be passive or active; that is, it can occur without or as a result of any external influence [15,18,19]. With passive delivery, water‐based preparations penetrate the microporated nail plate slowly due to a high coefficient of surface tension [15], and an aqueous solution of MB does not penetrate through the microporated nail plate at all [20].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Dual‐Stage Method of Active Er:YLF Laser Drug Delivery Through the Nail and Laser‐Induced Transformations of the Drug Extinction Spectrum

2021

View full text Add to dashboard Cite

Background and Objective A novel dual‐stage method for active laser drug delivery (DSLADD) in the treatment of nail diseases is being presented. This method includes sequentially performed microporation of the nail with submillisecond pulses of Er:YLF laser radiation through a layer of an aqueous solution of drug deposited on the nail surface (Stage 1) and exposure this layer to the same laser radiation to deliver drug under the nail plate (Stage 2). The delivery of methylene blue (MB) as one of the possible drugs in the treatment of nail diseases is investigated. The influence of the thickness of the MB layer, as well as the energy and number of applied laser pulses, on the rate of active laser delivery is discussed. To illustrate the possible effect of delivery on the drug delivered, special attention is paid to the deformation of the extinction spectrum of MB solution after laser irradiation. Study Design/Materials and Methods Diode‐pumped Er:YLF laser was used for DSLADD. The process of DSLADD under the nail plate was investigated using digital video microscopy. For different values of the thickness of MB solution layer applied to the nail plate and the energy of laser pulses, the number of laser pulses required to create a single through a microchannel in the nail plate and the number of laser pulses required to deliver the solution to the ventral side of the nail plate after its microporation were registered. The mass and the dose of MB solution penetrated under the nail plate, and the rate of MB solution delivery through a single microchannel was determined. Investigation of the influence of Er:YLF laser radiation parameters on the extinction spectrum of the drug was performed using a fiber spectrometer. The extinction spectra of the 0.001% aqueous solution of MB were recorded before and after exposure to a different number of Er:YLF laser pulses with the energy of 1–4 mJ. Results It was found that the minimum number of laser pulses required for active Er:YLF laser drug delivery under the nail corresponds to the MB layer thickness of 100 μm and the laser pulse energy of 4 mJ. It is shown that in this case, the rate of active laser delivery of MB solution reaches 0.26 ± 0.03 mg/pulse. The radiation of the Er:YLF laser affects the shape of the extinction spectrum of the aqueous solution of MВ, which is associated with the transition of the dye from the monomeric to dimeric state. Depending on the laser pulse energy, the fraction of a certain conformational state in the aqueous MB solution can decrease or increase, stimulating a possible change in its photodynamic and antiseptic activity. Conclusion For the first time, a novel DSLADD through the nail has been described and investigated in vitro. It was demonstrated that at Er:YLF laser pulse repetition rate of f = 30 Hz, microporation of the nail plate and drug delivery through a single microchannel will be about 1.5 s. Lasers Surg. Med. © 2021 Wiley Periodicals LLC

show abstract

Section: Introductionmentioning

confidence: 99%

Investigation of the Dual‐Stage Method of Active Er:YLF Laser Drug Delivery Through the Nail and Laser‐Induced Transformations of the Drug Extinction Spectrum

2021

View full text Add to dashboard Cite

show abstract

“…Moreover, their drawbacks include high cost and photoaging. Another research work has discussed the active transport of methylene blue solution as a drug via applying the Er: YLF-laser for nail perforation by means of pulsed radiation of microsecond Yb, Er: Glass laser, and the method was proved to be successful [29].…”

Section: Lasermentioning

confidence: 99%

Contemporary Techniques and Potential Transungual Drug Delivery Nanosystems for The Treatment of Onychomycosis

Abd-Elsalam

Abouelatta

2023

AAPS PharmSciTech

View full text Add to dashboard Cite

The humanoid nail is considered an exceptional protective barrier that is formed mainly from keratin. Onychomycosis is the cause of 50% of nail infections that is generally caused by dermatophytes. Firstly, the infection was regarded as a cosmetic problem but because of the tenacious nature of onychomycosis and its relapses, these infections have attracted medical attention. The first line of therapy was the oral antifungal agents which were proven to be effective; nevertheless, they exhibited hepato-toxic side effects, alongside drug interactions. Following, the opportunity was shifted to the topical remedies, as onychomycosis is rather superficial, yet this route is hindered by the keratinized layers in the nail plate. A potential alternative to overcome the obstacle was applying different mechanical, physical, and chemical methods to boost the penetration of drugs through the nail plate. Unfortunately, these methods might be expensive, require an expert to be completed, or even be followed by pain or more serious side effects. Furthermore, topical formulations such as nail lacquers and patches do not provide enough sustaining effects. Recently, newer therapies such as nanovesicles, nanoparticles, and nanoemulsions have emerged for the treatment of onychomycosis that provided effective treatment with possibly no side effects. This review states the treatment strategies such as mechanical, physical, and chemical methods, and highlights various innovative dosage forms and nanosystems developed in the last 10 years with a focus on advanced findings regarding formulation systems. Furthermore, it demonstrates the natural bioactives and their formulation as nanosystems, and the most relevant clinical outcomes. Graphical Abstract

show abstract

“…Pulse duration of 270 μs, energy 4 mJ, spot size 220 μm, and 30 Hz frequency were used. [34] In a study by Myers et al, 12 patients were successfully treated with a long-pulsed erbium glass 1534 nm laser. [35] Zhang et al studied the effect of combination of fractional 2940 nm Er:YAG laser with 5% amorolfine lacquer in onychomycosis.…”

Section: Parameters Used Study Endpointmentioning

confidence: 99%

Evolving role of lasers in nail therapeutics

Dhawan

Sharma²

2022

CSDM

View full text Add to dashboard Cite

The diseases of nails are chronic disorders due to the slow rate of growth of nails. The slow rate of nail growth results in long treatment regimens, thus having the potential of causing side effects and posing a limitation of administration to many people. Patients who suffer from organ dysfunction, elderly patients, patients under polypharmacy, and the inability of many patients to adhere to the complete regimen can cause the treatment of nail diseases to be frustrating for both the treating dermatologists as well as patients. Most nail disorders have formed a set treatment protocol for the administration of oral and topical drugs over the years. The use of lasers has yet to make its mark in the treatment of nail diseases due to lack of a universally accepted protocol. This review article looks into various studies evaluating the efficacy of lasers in nail diseases. Largely, this review is based on an evaluation of the effectiveness of lasers in onychomycosis (22 studies and 1 meta-analysis) and nail psoriasis (seven studies). While there is sufficient proof that lasers are effective in the treatment of nails, there is no gold standard for the type of lasers to be used for a particular disease, the treatment parameters, and the follow-up protocol. Evaluation of larger sample sizes against a control group and longer follow-ups are the need of the hour for the formulation of much-needed protocols.

show abstract

Application of Yb,Er:Glass laser radiation for active drug delivery at the treatment of onychomycosis

Cited by 6 publications

References 22 publications

Investigation of the Dual‐Stage Method of Active Er:YLF Laser Drug Delivery Through the Nail and Laser‐Induced Transformations of the Drug Extinction Spectrum

Investigation of the Dual‐Stage Method of Active Er:YLF Laser Drug Delivery Through the Nail and Laser‐Induced Transformations of the Drug Extinction Spectrum

Contemporary Techniques and Potential Transungual Drug Delivery Nanosystems for The Treatment of Onychomycosis

Evolving role of lasers in nail therapeutics

Contact Info

Product

Resources

About