Application of ultrasound-guided placement of markers for locating axillary lymph nodes of breast cancer

Ji, Xiaohui; Wei, Mengying; Wang, Liuyuan; Li, Juanjuan; Gao, Dongxia; Geng, Cuizhi

doi:10.21037/gs-21-598

Cited by 2 publications

(2 citation statements)

References 31 publications

(30 reference statements)

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“…Broad experience with image-guided marker placement for locating axillary lymph nodes has already been gained with breast cancer surgery after neoadjuvant chemotherapy. Marker placement is regarded as safe and simple with high detection rates 23,24 . Individual institutional or surgeon preference, experience and availability of localization technique should direct the choice for the preferred marker.…”

Section: Discussionmentioning

confidence: 99%

Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial

Reijers

Menzies

Akkooi

et al. 2022

Nat Med

165

129

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A djuvant immune checkpoint inhibition (CPI) and BRAF/ MEK-targeted therapies after therapeutic lymph node dissection (TLND) have improved relapse-free survival (RFS) in patients with clinical stage III nodal melanoma. Despite these improvements, approximately 40-50% of patients have a relapse within 3-5 years after TLND 1-3 . Preclinical and early clinical trial data suggest that neoadjuvant CPI leads to superior anti-tumor immunity and survival benefit compared to adjuvant CPI 4,5 . Similarly to stage IV melanoma, the combination of anti-CLTA-4 and anti-PD-1 appears to be superior to anti-PD-1 monotherapy in the neoadjuvant setting 6,7 . Previous clinical trials (OpACIN (NCT02437279) and OpACIN-neo (NCT02977052)) testing neoadjuvant ipilimumab (anti-CTLA-4) plus nivolumab (anti-PD-1) in stage III melanoma demonstrated high pathologic response rates (pRRs; 74-78%) and a strong association between pathologic response and RFS, with 94-100% of responding patients remaining free of relapse at 2 years 5,7-9 . Similarly, long-term benefit was observed upon complete response to CPI in stage IV melanoma, even after cessation of CPI [10][11][12] .The association between response and survival; the observed ongoing responses after cessation of therapy in stage IV melanoma; and the substantial morbidity from TLND [13][14][15][16] that impairs

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Section: Discussionmentioning

confidence: 99%

Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial

Reijers

Menzies

Akkooi

et al. 2022

Nat Med

165

129

View full text Add to dashboard Cite

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“…In clinical practice, during the treatment of tumors such as breast cancer, an absorber is used to determine the location of the tumor, and its location is tattooed with metal ink, or a metal capsule made of titanium is inserted into the body using a needle [46][47][48]. This can be confirmed as a metal artifact on X-ray, CT, MRI, and US images; however, because this is an invasive method, the side effects must be considered [46,49]. However, if the location is confirmed with a US image obtained using a non-invasively attached PU, radiation exposure can be reduced.…”

Section: Discussionmentioning

confidence: 99%

Effects of Polyurethane Absorber for Improving the Contrast between Fascia and Muscle in Diagnostic Ultrasound Images

Park,

Ahn,

Lee

et al. 2024

Applied Sciences

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In ultrasound diagnostics, acoustic absorbers block unwanted acoustic energy or prevent the reception of echo signals from structures outside the target area. Non-metallic absorbers provide a low-echoic signal that is suitable for observing the anatomy of the area to which the absorber is attached. In this study, we aimed to evaluate the effect of a polyurethane film absorber (PU) on ultrasound diagnostic imaging and investigate its effectiveness in improving the image contrast between the fascia and muscle structures. Twenty-six healthy men in their twenties participated in this study. The experiment was performed with the participant in the supine position and with an ultrasound transducer probe placed at the center of the measurement area on the abdomen. Images of the rectus abdominis (RA; muscle) and rectus sheath, e.g., fascia including superficial fascia (SF) and deep fascia (DF), obtained after attaching a PU, were compared with those obtained without the absorber (No_PU). The thickness was measured using brightness mode ultrasound imaging. To analyze the quantitative differences in the fascia and muscle images depending on the presence of the absorber, the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were derived from the signal intensities measured in the target areas. The thickness of the fascia and muscle was similar in all regions of interest, regardless of the absorber; therefore, the existing diagnostic value was maintained. Overall, the signal intensity decreased; however, the SNRs of the RA, SF, and DF differed significantly. The SNR of the RA decreased in the PU but increased for the SF and DF. The CNRs for SF-RA and DF-RA significantly increased with the PU. In this study, we demonstrated that the PU behaved similarly to previously used metallic absorbers, reducing the signal from the attachment site while accurately indicating the attachment site in the ultrasound images. Furthermore, the results showed that the PU efficiently distinguished fascia from surrounding tissues, which could support studies requiring increased signal contrast between fascia and muscle tissue and aid the clinical diagnosis of fascial diseases.

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Application of ultrasound-guided placement of markers for locating axillary lymph nodes of breast cancer

Cited by 2 publications

References 31 publications

Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial

Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial

Effects of Polyurethane Absorber for Improving the Contrast between Fascia and Muscle in Diagnostic Ultrasound Images

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