Application of tumor-targeting peptide-decorated polypeptide nanoparticles with doxorubicin to treat osteosarcoma

Qiu, Renna; Sun, Denghua; Bai, Yuzhuo; Li, Jiannan; Wang, Lizhe

doi:10.1080/10717544.2020.1856221

Cited by 22 publications

(21 citation statements)

References 29 publications

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“…Vimentin was a kind of epithelial-to-mesenchymal (EMT) marker highly expressed in many cancers, including colorectal cancer (Kim et al, 2020;Vermani et al, 2020). STP could specifically bind with vimentin, which can increase the tumor-targeting effects of mNPs (Qiu et al, 2020). The STP-mNPs/DOX are core-shell structured with DOX loaded in the core, and the PEG shell can protect the inside DOX while allowing the blood flow through.…”

Section: Resultsmentioning

confidence: 99%

“…Based on our previous study (Qiu et al, 2020), the mNPs/DOX and STP-mNPs/DOX were successfully synthesized. Supplementary Figure S1 shows the proton nuclear magnetic resonance (1H NMR) and Fourier-transform infrared (FTIR) spectroscopy of mNPs and STP-mNPs.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the morphology of the drug delivery systems plays an important role in the distribution within the body tissues. Spherical nanoparticles are more likely to be endocytosed within tumor cells (Qiu et al, 2020). Benefiting from the appropriate size and spherical morphology of nanoparticles, mNPs/DOX and STP-mNPs/DOX prolonged circulation and increased DOX accumulation in tumor sites through the EPR effect (Kobayashi et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…HPLC was used to evaluate the plasma pharmacokinetics of the free DOX, mNPs/DOX, and STP-mNPs/DOX (Zhu et al, (Qiu et al, 2020). The PEG shell of mNPs/ DOX and STP-mNPs/DOX could seal DOX within the nanoparticles and protect the agent while passaging the blood flow.…”

Section: Resultsmentioning

confidence: 99%

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Doxorubicin-Loaded Tumor-Targeting Peptide-Decorated Polypeptide Nanoparticles for Treating Primary Orthotopic Colon Cancer

Liu

Wang

et al. 2021

Front. Pharmacol.

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Colorectal cancer is the third most common malignant disease worldwide, and chemotherapy has been the standard treatment for colorectal cancer. However, the therapeutic effects of chemotherapy are unsatisfactory for advanced and recurrent colorectal cancers. Thus, increasing the treatment efficacy of chemotherapy in colorectal cancer is a must. In this study, doxorubicin (DOX)-loaded tumor-targeting peptide-decorated mPEG-P(Phe-co-Cys) nanoparticles were developed to treat orthotopic colon cancer in mice. The peptide VATANST (STP) can specifically bind with vimentin highly expressed on the surface of colon cancer cells, thus achieving the tumor-targeting effects. The nanoparticles are core-shell structured, which can protect the loaded DOX while passing through the blood flow and increase the circulation time. The disulfide bonds within the nanoparticles are sensitive to the glutathione-rich microenvironment of tumor tissues. Rupture of disulfide bonds of the nanoparticles leads to the continuous release of DOX, thus resulting in the apoptosis of the tumor cells. The in vivo experiments in mice with orthotopic colon cancer demonstrated that the synthesized DOX-loaded tumor-targeting peptide-decorated polypeptide nanoparticles showed properties of drug delivery systems and exhibited good antitumor properties. The synthesized nanoparticles show appropriate properties as one of the drug delivery systems and exhibit good antitumor properties after encapsulating DOX.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Doxorubicin-Loaded Tumor-Targeting Peptide-Decorated Polypeptide Nanoparticles for Treating Primary Orthotopic Colon Cancer

Liu

Wang

et al. 2021

Front. Pharmacol.

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“…REPL-NG/ONCM is supposed to be delivered within cells of interest as a form nanocomplex. Glutathione-triggered reduction of disulfide bonds is often utilized for intracellular drug delivery in a controlled manner (Chi et al, 2017; Feng et al, 2018; Qiu et al, 2020). Multiple disulfide bonds in REPL-NG can be degraded by intracellular glutathione releasing free ONCM within cytoplasmic compartment.…”

Section: Discussionmentioning

confidence: 99%

Oncomodulin derived from regeneration-associated macrophages in dorsal root ganglia promotes axon regeneration in the spinal cord

Kwon

Seo

Cho

et al. 2021

Preprint

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Preconditioning peripheral nerve injury enhances axonal regeneration of dorsal root ganglia (DRG) neurons in part by driving pro-regenerative perineuronal macrophage activation. How these regeneration-associated macrophages influence the neuronal capacity of axon regeneration remains elusive. The present study reports that oncomodulin (ONCM) is an effector molecule derived from the regeneration-associated macrophages. ONCM was highly upregulated in DRG macrophages following preconditioning injury and necessary for the preconditioning-induced neurite outgrowth. ONCM-deficient macrophages failed to generate neurite outgrowth activity of the conditioned medium in the in vitro model of neuron-macrophage interaction. CCL2/CCR2 signaling is an upstream regulator of ONCM since the ONCM upregulation was dependent on CCR2 and CCL2 overexpression-mediated conditioning effects were attenuated in ONCM-deficient mice. Direct application of ONCM potently increased neurite outgrowth in cultured DRG neurons by activating a distinct gene set, particularly neuropeptide-related genes. AAV-mediated overexpression of ONCM construct with the signal sequence increased neuronal secretion of ONCM and enhanced neurite outgrowth in an autocrine manner. For a clinically relevant approach, we developed a nanogel-mediated system for localized delivery of recombinant ONCM to DRG tissue. Electrostatic encapsulation of ONCM by a reducible epsilon-poly(L-lysine)-nanogel (REPL-NG) resulted in a slow release of ONCM allowing sustained bioactivity. Intraganglionic injection of REPL-NG/ONCM complex achieved a remarkable long-range axonal regeneration beyond spinal cord lesion, surpassing the extent expected from the preconditioning effects. The NG-mediated ONCM delivery could be exploited as a therapeutic strategy for promoting sensory axon regeneration following spinal cord injury.

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Thiolated Nanoparticles for Biomedical Applications: Mimicking the Workhorses of Our Body

Hock¹,

Racaniello

Aspinall

et al. 2021

Advanced Science

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Advances in nanotechnology have generated a broad range of nanoparticles (NPs) for numerous biomedical applications. Among the various properties of NPs are functionalities being related to thiol substructures. Numerous biological processes that are mediated by cysteine or cystine subunits of proteins representing the workhorses of the bodies can be transferred to NPs. This review focuses on the interface between thiol chemistry and NPs. Pros and cons of different techniques for thiolation of NPs are discussed. Furthermore, the various functionalities gained by thiolation are highlighted. These include overall bio-and mucoadhesive, cellular uptake enhancing, and permeation enhancing properties. Drugs being either covalently attached to thiolated NPs via disulfide bonds or being entrapped in thiolated polymeric NPs that are stabilized via inter-and intrachain crosslinking can be released at the diseased tissue or in target cells under reducing conditions. Moreover, drugs, targeting ligands, biological analytes, and enzymes bearing thiol substructures can be immobilized on noble metal NPs and quantum dots for therapeutic, theranostic, diagnostic, biosensing, and analytical reasons. Within this review a concise summary and analysis of the current knowledge, future directions, and potential clinical use of thiolated NPs are provided.

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Application of tumor-targeting peptide-decorated polypeptide nanoparticles with doxorubicin to treat osteosarcoma

Cited by 22 publications

References 29 publications

Doxorubicin-Loaded Tumor-Targeting Peptide-Decorated Polypeptide Nanoparticles for Treating Primary Orthotopic Colon Cancer

Doxorubicin-Loaded Tumor-Targeting Peptide-Decorated Polypeptide Nanoparticles for Treating Primary Orthotopic Colon Cancer

Oncomodulin derived from regeneration-associated macrophages in dorsal root ganglia promotes axon regeneration in the spinal cord

Thiolated Nanoparticles for Biomedical Applications: Mimicking the Workhorses of Our Body

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