Application of Traditional Chinese Medicines in Postoperative Abdominal Adhesion

Wu, Fengjie; Liu, Wenqin; Feng, Haixing; Li, Long; Hou, Lei; Hou, Chuqi

doi:10.1155/2020/8073467

Cited by 21 publications

(4 citation statements)

References 94 publications

(94 reference statements)

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“…In view of the role of reactive oxygen species (ROS) in the formation of adhesions, in previous studies, several antioxidants have been used to inhibit the development of peritoneal intra-abdominal adhesions. Gallic Acid, Iranian propolis, green tea extract, Rosmarinus officinalis extract, resveratrol, honokiol, berberine hydrochloride, rhynchophylline, silymarin, breviscapine are antioxidants employed in previous studies to alleviate post-operation adhesions [ 40 ]. In the present study, hydroalcoholic extract of Salvia miltiorrhiza , which has strong antioxidant agents such as rosmarinic acid, was used to avoid the intraperitoneal adhesions development.…”

Section: Discussionmentioning

confidence: 99%

Salvia miltiorrhiza hydroalcoholic extract inhibits postoperative peritoneal adhesions in rats

Raisi

Dezfoulian

Davoodi

et al. 2021

BMC Complement Med Ther

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Background One of the most prevalent postoperative complications is believed to be intra-abdominal peritoneal adhesions, which is followed by several complications. Several adhesion prevention products have been examined, yet none of them were found to be completely effective. The current research is conducted to evaluate the beneficial effects of Salvia miltiorrhiza hydroalcoholic extract in inhibiting postoperative peritoneal adhesions in rats. Methods Forty rats were randomly classified into five equal groups (n = 8): 1) the normal group did not undergo surgical operations, 2) the control group in which the adhesion was induced, and which did not receive any treatment, 3) distilled water group that received distilled water, and 4,5) treatment groups treated with 1 and 5% of Salvia miltiorrhiza hydroalcoholic extract. The rats were euthanized 14 days following the surgery and the macroscopic score, the microscopic score of granulomatous inflammation and granulation tissue formation, IHC markers (vimentin, CD31, IL-1β, COX-2, and iNOS), and oxidative stress biomarkers (MDA, GPx, CAT, and TAC) were assessed in the experimental groups of the study. Results The difference between the control group and other groups for the adhesions macroscopic score, microscopic score, IHC markers, and oxidative stress biomarkers was significant (p < 0.05). Distilled water had no protective effect on the formation of peritoneal adhesions. Salvia miltiorrhiza treatment in two different doses significantly reduced macroscopic and microscopic scores, MDA concentration, Vimentin, IL-1β, COX-2, and iNOS compared to the control group (p < 0.05). The levels of GPx, CAT, and TAC in the treatment groups increased significantly compared with the control group (p < 0.05). Our findings revealed that a higher dose of Salvia miltiorrhiza was more effective in reducing peritoneal adhesions, proinflammatory and mesenchymal cell markers, and oxidative stress. Conclusions Salvia miltiorrhiza extract, owing to its strong antioxidant and anti-inflammatory properties, could effectively reduce peritoneal adhesions. Therefore, Salvia miltiorrhiza is recommended to be used as an effective anti-peritoneal post-operative adhesive agent.

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Section: Discussionmentioning

confidence: 99%

Salvia miltiorrhiza hydroalcoholic extract inhibits postoperative peritoneal adhesions in rats

Raisi

Dezfoulian

Davoodi

et al. 2021

BMC Complement Med Ther

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“…TCM has long been used in China to treat several diseases, including depression, gastric precancerous lesions and postoperative abdominal adhesions ( 7 , 15 , 16 ). The most well-known TCM drug is artemisinin (qinghaosu), which has potent therapeutic effects against malaria ( 17 – 19 ).…”

Section: Discussionmentioning

confidence: 99%

Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2

Wang

et al. 2021

Mol Med Rep

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Musk ketone exerts antiproliferative effects on several types of cancer, such as lung and breast cancer. However, the effects and underlying mechanisms of action of musk ketone in gastric cancer (GC) are poorly understood. The present study aimed to investigate the effects of musk ketone in GC cells. The present study indicated that musk ketone exerted significant anticancer effects on GC cells. The IC 50 values of musk ketone were 4.2 and 10.06 µM in AGS and HGC-27 cells, respectively. Low dosage of musk ketone significantly suppressed the proliferation and colony formation of AGS and HGC-27 cells. Cell cycle arrest and apoptosis were induced by musk ketone. Furthermore, microarray data indicated that musk ketone treatment led to downregulation of various genes, including sorbin and SH3 domain containing 2 (SORBS2). Reverse transcription-quantitative PCR and immunoblotting results indicated that musk ketone repressed mRNA and protein expression levels of SORBS2. It was also shown that knockdown of SORBS2 inhibited the proliferation and colony formation of HGC-27 cells. The antiproliferative effects of musk ketone were decreased in HGC-27 cells with SORBS2 silencing. In summary, the present study indicated that musk ketone suppressed the proliferation and growth of GC partly by downregulating SORBS2 expression.

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“…However, most of these measures focus on optimizing patient care practices, and active intervention measures are still lacking. Traditional Chinese medicine (TCM) offers considerable advantages for treatment of GI diseases[ 8 - 11 ], but TCM decoctions are restricted during postoperative fasting. Thus, external treatment techniques based on TCM theories are widely applied to postoperative patients, with acupuncture being the most commonly used method[ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of intradermal needle therapy at combined acupoints on patients’ gastrointestinal function following surgery for gastrointestinal tumors

Guo¹,

Wang²,

Chen³

et al. 2022

World J Clin Cases

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BACKGROUND Postoperative gastrointestinal function recovery is critical for rapid rehabilitation of patients with gastrointestinal tumors. Traditional Chinese medicine offers considerable advantages for gastrointestinal disease treatment. However, no study has reported the clinical efficacy of intradermal needle therapy (INT) at the Yuan-source, Luo-connecting, and He-sea points of the corresponding meridian for gastrointestinal function in patients following surgery for gastrointestinal tumors. AIM To investigate the effect of INT at combined acupoints on patients’ gastrointestinal function following surgery for gastrointestinal tumors. METHODS This randomized controlled trial was conducted at the Second Affiliated Hospital of Xi’an Jiaotong University on patients with diagnosed gastrointestinal cancer, no distant metastases or organ failure, and hospitalized for elective radical tumor resection, who did not receive preoperative radiotherapy or chemotherapy. Participants were randomly allocated to either the intervention ( n = 32) or the control ( n = 32) group. Participants in the control group received enhanced recovery care, while those in the intervention group received enhanced recovery care combined with INT at the Yuan-source, Luo-connecting, and He-sea points. After surgery, INT was performed immediately upon the patient's return to the ward, and continued for seven consecutive days. The independent samples t -test, chi-square test, and generalized estimating equations were used for data analysis. RESULTS The participants’ ages ranged from 40 to 80 years (average 63 ± 10.1 years). Most participants underwent surgery for either gastric (43.8%) or colon cancer (39.1%) and had adenocarcinoma (87.5%). Significant differences were noted in time to first postoperative flatus passage (66 ± 27 h vs 103 ± 41 h, P < 0.001), time to first defecation (106 ± 44 h vs 153 ± 50 h, P < 0.001), and time to first oral feeding (73 ± 30 h vs 115 ± 38 h, P < 0.001) between the intervention and control groups. Gastrointestinal symptoms, including abdominal distension, nausea, and fatigue 48 h and 72 h after surgery, were significantly alleviated in the intervention group compared with that observed in the control group ( P < 0.05). CONCLUSION INT at the Yuan-source, Luo-connecting, and He-sea points can promote recovery of gastrointestinal function and ease gastrointestinal symptoms in patients following surgical resection of gastrointestinal tumors.

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Application of Traditional Chinese Medicines in Postoperative Abdominal Adhesion

Cited by 21 publications

References 94 publications

Salvia miltiorrhiza hydroalcoholic extract inhibits postoperative peritoneal adhesions in rats

Salvia miltiorrhiza hydroalcoholic extract inhibits postoperative peritoneal adhesions in rats

Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2

Effect of intradermal needle therapy at combined acupoints on patients’ gastrointestinal function following surgery for gastrointestinal tumors

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