Application of traditional Chinese medicine preparation in targeting drug delivery system

Abstract

(2015) Application of traditional Chinese medicine preparation in targeting drug delivery system, Drug Delivery, 22:3, 258-265, DOI: 10.3109/10717544.2014 AbstractTargeting drug system (TDS) or targeted drug delivery system (TDDS) is a new kind of drug delivery system which could make drug to be directly concentrated on the target site with high curative effects and low side-effects. As the quintessence of Chinese culture, traditional Chinese medicine (TCM) has a large advantage in many disease clinical treatments, especially in cancer, hypertension and many other intractable diseases owing to their low toxicity and side-effects relative to western medicine. This article reviews literatures on development of TCM-targeted preparations which were published in the past 10 years. TDS including active-targeting, passive-targeting and physical-chemical-targeting preparations were introduced through domestic and overseas literatures to reveal the unique advantages of TCM-targeting preparations in drug delivery system. In this article, we have reviewed some kinds of TCM-targeting preparations and indicated that great attention should be paid to the research on the TCM-targeting preparations.

Anticancer drug discovery from Chinese medicinal herbs

“…Antibody–drug conjugate system successfully reduced the side effects caused by lidamycin [ 41 ], which set an example for toxic Chinese medicinal herbs development. Other pharmaceutical methods including nanoparticle technology and micelle preparation also have been documented to further improve the solubility and stability of compounds [ 42 ]. For example, poor delivery and stability of artemisinin reduce the anticancer effect, but both can be improved by encapsulating artemisinin into nano drug delivery systems.…”

Time Interval of Two Injections and First-Dose Dependent of Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomal Gambogenic Acid: The Contribution of PEG-Specific IgM

“…[29][30][31] However, a large number of herbal medicines are needed to be encapsulated into nanocarriers (e.g., PEGylated liposomes) because of their relatively low aqueous solubility, short biological half-life, and poor bioavailability. 32 Much more matters remain unknown for PEGylated liposomal herbal medicines than PEGylated liposomal chemotherapeutic agents (i.e., Doxorubicin, Oxaliplatin, and mitoxantrone) for concerning the ABC phenomenon. Gambogenic acid ([GEA], Supplemental Fig.…”

Folic acid-modified celastrol nanoparticles: synthesis, characterization, anticancer activity in 2D and 3D breast cancer models

“…Nanoparticle encapsulation could improve the solubility of active components from traditional Chinese herbs. For example, triptolide-loaded nanoparticles improved the solubility of triptolide, controlled its release, realised the target delivery of triptolide and avoided the toxicity at non-target site [3]. Nowadays, noble metals like platinum, gold and silver are recently being reckoned as treasured precursors in the design of inventive nano-device systems that are fabricated and incorporated for the functional aspects of nanoparticles [4].…”