Application of tissue engineering techniques in tracheal repair: a bibliometric study

Xu, Xiangyu; Shen, Zhiming; Shan, Yibo; Sun, Fei; Lu, Yi; Zhu, Jianwei; Sun, Yiqi; Shi, Hongcan

doi:10.1080/21655979.2023.2274150

Cited by 3 publications

(2 citation statements)

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“…In the field of tracheal bioengineering, the structure of hydrogels (3D multilayer polymer) has been proven to be a valid surrogate for the extracellular matrix (ECM), sustaining cells' organization, viability, and growth [30] and avoiding bacterial cell growth [31,32]. In addition to biocompatibility, the similarities with chondrocyte-derived tissues (such as cartilage) constitute a further argument for their utilization [33], and this matrix is extensively adopted in tracheal tissue engineering [34,35].…”

Section: Scaffold Optionsmentioning

confidence: 99%

Tracheal Tissue Engineering: Principles and State of the Art

Mammana,

Bonis,

Verzeletti

et al. 2024

Bioengineering

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Patients affected by long-segment tracheal defects or stenoses represent an unsolved surgical issue, since they cannot be treated with the conventional surgery of tracheal resection and consequent anastomosis. Hence, different strategies for tracheal replacement have been proposed (synthetic materials, aortic allografts, transplantation, autologous tissue composites, and tissue engineering), each with advantages and drawbacks. Tracheal tissue engineering, on the other hand, aims at recreating a fully functional tracheal substitute, without the need for the patient to receive lifelong immunosuppression or endotracheal stents. Tissue engineering approaches involve the use of a scaffold, stem cells, and humoral signals. This paper reviews the main aspects of tracheal TE, starting from the choice of the scaffold to the type of stem cells that can be used to seed the scaffold, the methods for their culture and expansion, the issue of graft revascularization at the moment of in vivo implantation, and experimental models of tracheal research. Moreover, a critical insight on the state of the art of tracheal tissue engineering is also presented.

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Section: Scaffold Optionsmentioning

confidence: 99%

Tracheal Tissue Engineering: Principles and State of the Art

Mammana,

Bonis,

Verzeletti

et al. 2024

Bioengineering

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“… 121 , 122 The mismatch in mechanical properties, rigidity causing erosion of adjacent blood vessels, and the inability to integrate within surrounding tissue resulted in dislodgement during coughing and airway obstruction. 123 Other solid prostheses, including polyethylene (PE), 124 stainless‐steel wire, 125 silicone stent, 126 and tantalum, 127 have also been explored as alternatives in tracheal reconstruction.…”

Section: Advancements In Clinical Translationmentioning

confidence: 99%

Tissue‐engineered tracheal implants: Advancements, challenges, and clinical considerations

Wei,

Zhang,

Luo

et al. 2024

Bioengineering & Transla Med

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Restoration of extensive tracheal damage remains a significant challenge in respiratory medicine, particularly in instances stemming from conditions like infection, congenital anomalies, or stenosis. The trachea, an essential element of the lower respiratory tract, constitutes a fibrocartilaginous tube spanning approximately 10–12 cm in length. It is characterized by 18 ± 2 tracheal cartilages distributed anterolaterally with the dynamic trachealis muscle located posteriorly. While tracheotomy is a common approach for patients with short‐length defects, situations requiring replacement arise when the extent of lesion exceeds 1/2 of the length in adults (or 1/3 in children). Tissue engineering (TE) holds promise in developing biocompatible airway grafts for addressing challenges in tracheal regeneration. Despite the potential, the extensive clinical application of tissue‐engineered tracheal substitutes encounters obstacles, including insufficient revascularization, inadequate re‐epithelialization, suboptimal mechanical properties, and insufficient durability. These limitations have led to limited success in implementing tissue‐engineered tracheal implants in clinical settings. This review provides a comprehensive exploration of historical attempts and lessons learned in the field of tracheal TE, contextualizing the clinical prerequisites and vital criteria for effective tracheal grafts. The manufacturing approaches employed in TE, along with the clinical application of both tissue‐engineered and non‐tissue‐engineered approaches for tracheal reconstruction, are discussed in detail. By offering a holistic view on TE substitutes and their implications for the clinical management of long‐segment tracheal lesions, this review aims to contribute to the understanding and advancement of strategies in this critical area of respiratory medicine.

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