Abstract:Purpose: Three-dimensional (3D) printing technology has emerged as a new treatment method due to its precision and personalization. This study aims to explore the application of a 3D-printed personalized porous tantalum cone for reconstructing the bone defect in total knee arthroplasty (TKA) revision.Methods: Between November 2017 and October 2020, six patients underwent bone reconstruction using 3D-printed porous tantalum cones in TKA revision. The knee function was assessed using the Hospital for Special Sur… Show more
“…In addition, Wang et al [104] documented a case study of an 83 year-old female patient suffering from chronic inflammation, tibial prosthesis loosening with bone loss, and severe osteoporosis who was treated with personalized 3D-printed porous pure tantalum pads assisting a left total knee arthroplasty (TKA) with good postoperative recovery and good follow-up results. Moreover, a study conducted by Ao et al [107] demonstrated the use of 3D-printed porous tantalum cones in bone reconstruction for six patients who had undergone revision TKA. The postoperative follow-up revealed that the implanted joint achieved vertebral stabilization, effectively repairing metaphyseal bone defects in the knee and enhancing joint function and quality of life.…”
Section: Application Of Porous Tantalum Bone Scaffoldsmentioning
Porous tantalum scaffolds offer a high degree of biocompatibility and have a low friction coefficient. In addition, their biomimetic porous structure and mechanical properties, which closely resemble human bone tissue, make them a popular area of research in the field of bone defect repair. With the rapid advancement of additive manufacturing, 3D-printed porous tantalum scaffolds have increasingly emerged in recent years, offering exceptional design flexibility, as well as facilitating the fabrication of intricate geometries and complex pore structures that similar to human anatomy. This review provides a comprehensive description of the techniques, procedures, and specific parameters involved in the 3D printing of porous tantalum scaffolds. Concurrently, the review provides a summary of the mechanical properties, osteogenesis and antibacterial properties of porous tantalum scaffolds. The use of surface modification techniques and the drug carriers can enhance the characteristics of porous tantalum scaffolds. Accordingly, the review discusses the application of these porous tantalum materials in clinical settings. Multiple studies have demonstrated that 3D-printed porous tantalum scaffolds exhibit exceptional corrosion resistance, biocompatibility, and osteogenic properties. As a result, they are considered highly suitable biomaterials for repairing bone defects. Despite the rapid development of 3D-printed porous tantalum scaffolds, they still encounter challenges and issues when used as bone defect implants in clinical applications. Ultimately, a concise overview of the primary challenges faced by 3D-printed porous tantalum scaffolds is offered, and corresponding insights to promote further exploration and advancement in this domain are presented.
“…In addition, Wang et al [104] documented a case study of an 83 year-old female patient suffering from chronic inflammation, tibial prosthesis loosening with bone loss, and severe osteoporosis who was treated with personalized 3D-printed porous pure tantalum pads assisting a left total knee arthroplasty (TKA) with good postoperative recovery and good follow-up results. Moreover, a study conducted by Ao et al [107] demonstrated the use of 3D-printed porous tantalum cones in bone reconstruction for six patients who had undergone revision TKA. The postoperative follow-up revealed that the implanted joint achieved vertebral stabilization, effectively repairing metaphyseal bone defects in the knee and enhancing joint function and quality of life.…”
Section: Application Of Porous Tantalum Bone Scaffoldsmentioning
Porous tantalum scaffolds offer a high degree of biocompatibility and have a low friction coefficient. In addition, their biomimetic porous structure and mechanical properties, which closely resemble human bone tissue, make them a popular area of research in the field of bone defect repair. With the rapid advancement of additive manufacturing, 3D-printed porous tantalum scaffolds have increasingly emerged in recent years, offering exceptional design flexibility, as well as facilitating the fabrication of intricate geometries and complex pore structures that similar to human anatomy. This review provides a comprehensive description of the techniques, procedures, and specific parameters involved in the 3D printing of porous tantalum scaffolds. Concurrently, the review provides a summary of the mechanical properties, osteogenesis and antibacterial properties of porous tantalum scaffolds. The use of surface modification techniques and the drug carriers can enhance the characteristics of porous tantalum scaffolds. Accordingly, the review discusses the application of these porous tantalum materials in clinical settings. Multiple studies have demonstrated that 3D-printed porous tantalum scaffolds exhibit exceptional corrosion resistance, biocompatibility, and osteogenic properties. As a result, they are considered highly suitable biomaterials for repairing bone defects. Despite the rapid development of 3D-printed porous tantalum scaffolds, they still encounter challenges and issues when used as bone defect implants in clinical applications. Ultimately, a concise overview of the primary challenges faced by 3D-printed porous tantalum scaffolds is offered, and corresponding insights to promote further exploration and advancement in this domain are presented.
“…The biological response to the host bone, on the other hand, is usually achieved by monolithic or surface modification of such implants [ 9 ]. In just the past few years, metal 3D printing technology in the medical field, especially the application of orthopedics has been highly valued, and its innovative potential and application prospects are more generally favored [ 50 , 108 , [184] , [185] , [186] , [187] , [188] ]. Several metal 3D printing orthopedic implant applications are shown in Fig.…”
Section: Clinical Applicationsmentioning
confidence: 99%
“…To date, research on the clinical application of patient-specific implants has focused on bone tumor surgery, joint replacement surgery, spinal implants, and traumatic fracture fixation and reconstruction as listed in Table 3 , Table 4 , Table 5 , Table 6 . Figure 4 Clinical application of metal 3D printing orthopedic implants (A) Radial head prosthesis [ 184 ], (B) Porous scaffolds in femoral defect [ 108 ], (C) Total talus implant [ 185 ], (D) Spine fusion device [ 186 ], (E) Trabecular acetabular cup [ 187 ], (F) Cones in total knee arthroplasty [ 188 ], reproduced with permission. …”
“…Bone tissue grows normally only when it is subjected to an appropriate mechanical load. Insufficient force will cause bone absorption, whereas excessive stress can destroy the bone tissues ( Ao et al, 2022 ).…”
Porous tantalum (Ta) implants have been developed and clinically applied as high-quality implant biomaterials in the orthopedics field because of their excellent corrosion resistance, biocompatibility, osteointegration, and bone conductivity. Porous Ta allows fine bone ingrowth and new bone formation through the inner space because of its high porosity and interconnected pore structure. It contributes to rapid bone integration and long-term stability of osseointegrated implants. Porous Ta has excellent wetting properties and high surface energy, which facilitate the adhesion, proliferation, and mineralization of osteoblasts. Moreover, porous Ta is superior to classical metallic materials in avoiding the stress shielding effect, minimizing the loss of marginal bone, and improving primary stability because of its low elastic modulus and high friction coefficient. Accordingly, the excellent biological and mechanical properties of porous Ta are primarily responsible for its rising clinical translation trend. Over the past 2 decades, advanced fabrication strategies such as emerging manufacturing technologies, surface modification techniques, and patient-oriented designs have remarkably influenced the microstructural characteristic, bioactive performance, and clinical indications of porous Ta scaffolds. The present review offers an overview of the fabrication methods, modification techniques, and orthopedic applications of porous Ta implants.
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