Application of the “VARICOL” process to the separation of the isomers of the SB-553261 racemate

Ludemann‐Hombourger, Olivier; Pigorini, Giuseppe; Nicoud, Roger‐Marc; Ross, David S.; Terfloth, Gerald

doi:10.1016/s0021-9673(01)01568-0

Cited by 95 publications

(55 citation statements)

References 3 publications

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“…The Varicol process was proposed by Novasep and the first experimental results were recently published As was presented in the Introduction, Varicol is a [46]. The last part of this work will present an new continuous chromatographic process and coneffective comparison between SMB and Varicol sists of a modification of the classic SMB operation operations, by evaluating the g 3 g separation 3 2…”

Section: 3 Varicol Operationmentioning

confidence: 99%

Design of simulated moving bed and Varicol processes for preparative separations with a low number of columns

Pais

Rodrigues

2003

Journal of Chromatography A

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Simulated moving bed (SMB) chromatography has received significant attention in the last decade, particularly as regards the production of very valuable products, such as enantiomerically pure pharmaceutical compounds. Recent applications in the pharmaceutical industry use SMB systems containing a low total number chromatographic columns, usually four to eight. This paper deals with the modeling and simulation of SMB systems with only four, five and six columns. In particular, two modeling strategies, the equivalent true moving bed and the real SMB models, are compared for these units in terms of separation regions and system productivity. Also, the recently proposed Varicol process is analyzed and compared with the classical SMB operation, and the advantages of this new operation mode are shown for systems using a low number of columns. 

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Section: 3 Varicol Operationmentioning

confidence: 99%

Design of simulated moving bed and Varicol processes for preparative separations with a low number of columns

Pais

Rodrigues

2003

Journal of Chromatography A

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“…Varicol is a continuous preparative multicolumn chromatographic system that, in general, operates with a smaller number of columns than the conventional simulated moving bed (SMB) process (Ludemann-Hombourger et al, 2000;Ludemann-Hombourger et al, 2002;Gomes and Rodrigues, 2012;Schulte et al, 2005). The underlying principle of the Varicol process is the asynchronous shift of the inlet and outlet ports during an overall switching time.…”

Section: Introductionmentioning

confidence: 99%

“…The more strongly adsorbed component is the primary compound in the extract stream, whereas the less strongly adsorbed component predominates in the raffinate stream (Ludemann-Hombourger et al, 2000;Adam et al, 2002). The Varicol process has been proven to be superior to the SMB process in terms of product purity and productivity in several studies (Ludemann-Hombourger et al, 2002;Wongso et al, 2004;Wongso et al, 2005;Zhang et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Chromatographic Separation of Verapamil Racemate Using a Varicol Continuous Multicolumn Process

Cremasco

Santana²

2015

Braz. J. Chem. Eng.

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-Verapamil is a chiral drug that is marketed in its racemic form, but because of the pharmacological effects due to molecule's chirality, one of the enantiomers is more potent, and the other exhibits different activities of therapeutic interest. The preparative separation of the verapamil enantiomers was performed using a continuous Varicol unit operated on a scale of 1 g/day. Amylose tris(3,5-dimethylphenylcarbamate) functioned as the stationary phase, and n-hexane/isopropanol/ethanol mixtures were used as the mobile phase. Diethylamine was used as the additive. The enantiomeric purities were 93.0% for S-(-)-verapamil and 92.0% for R-(+)-verapamil in the raffinate and extract streams, respectively. The unit provided productivities of 0.18 kg of raffinate per day per kg of adsorbent and 0.20 kg of extract per day per kg of adsorbent when using a feed concentration of 12.5 g L -1 .

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“…Multicolumn chromatographic processes like simulated moving bed (SMB) have been applied especially in the separation of binary mixtures [4,5]. According to these references, several theoretical and experimental results in the literature indicate that due to the new degree of freedom the Varicol process is found to be a more favorable chromatographic technique than SMB, especially in terms of productivity and eluent consumption.…”

Section: Introductionmentioning

confidence: 99%

Chromatographic Separation and Purification of Mitotane Racemate in a Varicol Multicolumn Continuous Process

et al. 2011

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The multicolumn continuous chromatographic separation process that increases throughput, purity, and yield compared to batch chromatography is considered as an important preparative technique to purify pharmaceutical drugs. Mitotane is a chiral drug marketed in the racemic form but pharmacological effects due to molecule chirality indicate that one of the enantiomers is more potent. Preparative separation of the mitotane enantiomers was performed by a continuous Varicol unit operated on a scale of 30 g/day. Amylose tris(3,5-dimethylphenylcarbamate) functioned as the stationary phase and acetonitrile-isopropanol mixtures as mobile phases. The enantiomeric purities obtained were 97.0 % for S-(-)-mitotane and 96.8 % for R-(+)-mitotane in the raffinate and extract streams, respectively. The unit provided productivities of 1.14 kg raffinate per day and kg adsorbent and 0.68 kg extract per day and kg adsorbent.

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Application of the “VARICOL” process to the separation of the isomers of the SB-553261 racemate

Cited by 95 publications

References 3 publications

Design of simulated moving bed and Varicol processes for preparative separations with a low number of columns

Design of simulated moving bed and Varicol processes for preparative separations with a low number of columns

Chromatographic Separation of Verapamil Racemate Using a Varicol Continuous Multicolumn Process

Chromatographic Separation and Purification of Mitotane Racemate in a Varicol Multicolumn Continuous Process

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