Application of the Oxidative Stability Index for Assessing the Antioxidant Properties of Flavonoids

Harris, Gabriel K.; Willcox, Joye K; Catignani, George L.

doi:10.1111/j.1745-4514.2004.tb00076.x

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…This result is remarkable because quercetin exists as a particulate dispersion in LLDPE. Several studies have shown that antioxidants, including quercetin,31, 32 can function effectively in suspension in bulk vegetable oils 33. The reported solubility limit of quercetin in soybean oil is ∼100 μM (34 mg L −1 ),34 which is likely on the order of its solubility in polyethylene.…”

Section: Resultsmentioning

confidence: 99%

Polymer processing and characterization of LLDPE films loaded with α‐tocopherol, quercetin, and their cyclodextrin inclusion complexes

Koontz

Marcy

O’Keefe

et al. 2010

J of Applied Polymer Sci

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Natural antioxidant additives were compounded into linear low-density polyethylene (LLDPE) using a twin-screw counter-rotating mixer and compression molded into films. Manufactured LLDPE films contained 2715 mg kg À1 a-tocopherol in its free and b-cyclodextrin complexed form and 1950 mg kg À1 quercetin in its free and c-cyclodextrin complexed form. Both cyclodextrin complexes were loaded into films at 1.5% by weight. These natural antioxidants were incorporated into LLDPE resins with two different catalyst types, Ziegler-Natta and metallocene. Films were characterized by optical microscopy, oxidation induction time (OIT), oxygen transmission rate, contact angle analysis, and atomic force microscopy (AFM). All antioxidant additives increased the oxidative stability of LLDPE as measured by increased OIT, particularly quercetin. Natural antioxidants and their cyclodextrin inclusion complexes may provide a dual function in packaging to protect the polymer from oxidative degradation during melt processing and to delay the onset of oxidation of the packaged food during storage.

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Section: Resultsmentioning

confidence: 99%

Polymer processing and characterization of LLDPE films loaded with α‐tocopherol, quercetin, and their cyclodextrin inclusion complexes

Koontz

Marcy

O’Keefe

et al. 2010

J of Applied Polymer Sci

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“…From oxidative stability index value measurements it has been found that chrysin displays lower antioxidant activity than other flavonoids [48].…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

Role of oxidative stress in the antitumoral action of a new vanadyl(IV) complex with the flavonoid chrysin in two osteoblast cell lines: relationship with the radical scavenger activity

et al. 2010

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The new complex [VO(chrysin)(2)EtOH](2) (VOchrys) has been synthesized and thoroughly characterized. Fourier transform IR, UV-vis, diffuse reflectance, and EPR spectroscopies as well as elemental analysis and thermal measurements were performed. In solution, different species could be detected by EPR spectroscopy as a function of the ligand-to-metal ratio. The stoichiometry of the chelate complex formed at pH 5 was also determined by spectrophotometric titrations. Since flavonoids are natural antioxidant compounds, the antioxidant capacity of chrysin and its vanadyl(IV) complex was investigated using different radicals. Chrysin and its complex were not able to diminish the level of superoxide and 1,1-diphenyl-2-picrylhydrazyl radicals to a great extent. In contrast, they were strong scavengers for 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid diammonium salt radical cations and OH. radicals with a greater potency for VOchrys. Taking into account their selective antioxidant properties, we investigated the bioactivity of these compounds in two osteoblast-like cells in culture. Chrysin and VOchrys caused an inhibition of cell proliferation in MC3T3E1 normal osteoblasts and UMR106 tumor cells in a dose-response manner, with a greater effect in the latter cell line. The generation of reactive oxygen species (ROS) was evaluated in both cell lines and a correlation could be established between the antiproliferative effects of chrysin and the increase in the ROS levels. The complex did not generate types of ROS that can be detected by the dihydrorhodamine 123 technique so the antiproliferative effect may be attributed to the formation of other radicals such as superoxide, which is not detected by this probe. The morphological alterations were in agreement with these changes.

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“…2003). Recently, phenolics, particularly flavonoids, have gained much attention because of their high antioxidant activities and radical scavenging abilities with less toxicity than synthetic antioxidants (Harris et al. 2004; Degl'Innoocenti et al.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on Phenolic Compounds and Antioxidant Activity of Feutrell's Early and Kinnow Peel Extracts

Hayat¹,

Abbas

Jia

et al. 2011

Journal of Food Biochemistry

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Phenolic compounds and antioxidant activities of 70% ethanol extracts of the peels from two Pakistani citrus mandarin cultivars, namely, Feutrell's Early and Kinnow, were investigated. Results were compared with synthetic antioxidants and also with Chinese Ponkan mandarin peel to see the varietal and geographical effects. The cultivars showed the significant differences in total polyphenols, flavonoids and phenolic acids. Ferulic acid ranging from 1193.84 to 1640.87 mg/g dry weight was the dominant phenolic acid in all cultivars. The antioxidant activity of extracts as determined by b-carotene bleaching assay ranged from 28.40 to 43.78% and was in the following order: Kinnow < Feutrell's Early < Ponkan. A strong positive correlation was observed among the analyzed phenolic compounds and the antioxidant capacities. Results reveal that citrus peels under study might be used as an economical source of natural antioxidants, and both cultivars and geographical factors affect the bioactive composition in citrus mandarin peel. PRACTICAL APPLICATIONSFoods from plant origin usually contain natural antioxidants that can scavenge free radical and may contribute to reduce human diseases. Therefore, many studies have been undertaken to find the new sources of antioxidant compounds. Citrus mandarin (Citrus reticulata Blanco) peels are the source of bioactive compounds with enhanced antioxidant activity. Feutrell's Early and 1 Corresponding

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Application of the Oxidative Stability Index for Assessing the Antioxidant Properties of Flavonoids

Cited by 6 publications

References 32 publications

Polymer processing and characterization of LLDPE films loaded with α‐tocopherol, quercetin, and their cyclodextrin inclusion complexes

Polymer processing and characterization of LLDPE films loaded with α‐tocopherol, quercetin, and their cyclodextrin inclusion complexes

Role of oxidative stress in the antitumoral action of a new vanadyl(IV) complex with the flavonoid chrysin in two osteoblast cell lines: relationship with the radical scavenger activity

Comparative Study on Phenolic Compounds and Antioxidant Activity of Feutrell's Early and Kinnow Peel Extracts

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