Application of the novel method in the diagnosis and treatment of median rhomboid glossitis Candida-associated

Abstract

The aim of this work is to demonstrate how current molecular techniques should be integrated in the diagnostic process and can have a crucial role in the management of oral fungal infections. A case of median rhomboid glossitis Candida-associated and its resolution will be described step by step. At the time of the first observation, the lesion on the surface of the tongue did not respond to the previous administration of topical antifungal agent, such a nystatin. Firstly, in order to identify the causative agent and confirm Candida albicans infection, a brushing of the lesion was performed and polymerase chain reaction analysis was carried out. In addition, deoxyribonucleic acid sequencing method, known as Pyrosequencing®, was used in the detection of point mutations commonly associated with fluconazole resistance and consequently, in the prediction of susceptibility to azole agents. According to molecular findings, the administration of fluconazole has therefore led to resolution of the case in 2 weeks. This case highlights how the use of molecular techniques, now-a-days, can assist the clinicians to quickly obtain the report with highly accurate and precise results and appropriately support them in the diagnosis and therapeutic process.

Diagnosis of Lingual Atrophic Conditions: Associations with Local and Systemic Factors. A Descriptive Review

“…AIDS, organ transplant, chemotherapy) or favourable environmental conditions ( i.e. xerostomia, poor oral hygiene, diabetes) [83-86]. Candida infection promotes different clinical manifestations on the tongue surface, both acute and chronic.…”

“…The aetiology of this disease is controversial, but it is usually considered as a clinical variant of a candida infection. A microbiological analysis of tongue surface and a thorough anamnesis are key to diagnosis [86]. …”

Enhanced antifungal effects of amphotericin B-TPGS-b-(PCL-ran-PGA) nanoparticles in vitro and in vivo

“…The incidence of mucosal and cutaneous fungal infections increasing dramatically worldwide, especially in patients who are immunocompromised because of cancer chemotherapy, immunosuppressive therapy after organ transplantation, or human immunodeficiency virus infection. 1,2 Most of these infections are caused by Candida albicans, non-albicans Candida spp., Candida tropicalis, Candida glabrata, and Candida Krusei. 3,4 Echinocandins, polyenes, pyrimidine, allylamine, and azoles are the most common antifungal agents available for the treatment of topical Candida spp.…”

Black hairy tongue in a patient with amyotrophic lateral sclerosis

“…Since an alteration of oral or systemic ecosystem can favourite the development of a pathologic condition, several studies emphasised the importance of oral hygiene procedures in order to mantain the microbial equilibrium into the oral niches. [ 15 16 ] According to the literature, the removal of lingual coating can prevent the establishment of periodontal infections[ 12 ] as well as systemic complications. In 2008, Abe et al .…”