Application of the multidimensional fatigue inventory (MFI-20) in cancer patients receiving radiotherapy

Smets, Ellen M. A.; Garssen, Bart; Cull, Ann; Haes, J.C.J.M. de

doi:10.1038/bjc.1996.42

Cited by 382 publications

(231 citation statements)

References 12 publications

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“…Previous investigations have shown that women with breast cancer undergoing chemotherapy experience both disturbed sleep and increased fatigue [18,26,37,40,41,45]. The data from the current study showed that the women experienced both disturbed sleep and fatigue before they began chemotherapy.…”

Section: Discussionsupporting

confidence: 48%

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Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer

Ancoli‐Israel

Liu

Marler

et al. 2005

Support Care Cancer

264

206

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Goals-Previous investigations have shown that women undergoing chemotherapy for breast cancer experience both disturbed sleep and fatigue. However, most of the previous research examined women either during or after chemotherapy. This study examined sleep, fatigue, and circadian rhythms in women with breast cancer before the start of chemotherapy.Patients and methods-Eighty five women with Stages I-IIIA breast cancer who were scheduled to begin adjuvant or neo-adjuvant anthracycline-based chemotherapy participated. Each had sleep/ wake activity recorded with actigraphy for 72 consecutive hours and filled out questionnaires on sleep, fatigue, depression, and functional outcome.Main results-On average, the women slept for about 6 h a night and napped for over an hour during the day. Sleep was reported to be disturbed and fatigue levels were high. Circadian rhythms were robust, but women who were more phase-delayed reported more daily dysfunction (p<0.01). Conclusions-The data from the current study suggest that the women with breast cancer likely experience both disturbed sleep and fatigue before the beginning of chemotherapy. Although their circadian rhythms are robust, breast cancer patients with more delayed rhythms experience more daily dysfunction secondary to fatigue. These data suggest that strategies to improve disturbed sleep and to phase-advance circadian rhythms prior to initiation of chemotherapy may be beneficial in improving daily function in breast cancer patients.

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Section: Discussionsupporting

confidence: 48%

“…One of the most frequent and disturbing complaints of patients with cancer is fatigue [37,40,41,45]. There is no universally accepted definition of fatigue, but what one descriptor often included is sleepiness during the day accompanied by poor sleep at night [23,45].…”

Section: Introductionmentioning

confidence: 99%

Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer

Ancoli‐Israel

Liu

Marler

et al. 2005

Support Care Cancer

264

206

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“…This test, which requires divided attention, sustained concentration and efficient information processing, has been shown to be sensitive to subtle neurocognitive deficits. In other patient samples PASAT scores have been found to mirror patients' self-reported difficulties (Johnson et al, 1994 (Fobair et al, 1986;Smets et al, 1996). Whether or not some common underlying physiological mechanism can be elucidated, this finding further underlines the importance of assessing patients who complain of cognitive dysfunction or fatigue for clinically significant and potentially remediable emotional disturbance.…”

Section: Discussionmentioning

confidence: 84%

“…Multi-Dimensional Fatigue Inventory (MFI) This 20-item Dutch instrument has been pretested in English in a mixed group of patients receiving radiotherapy in our department (Smets et al, 1995a(Smets et al, , 1996 (Bentall et al, 1993).…”

mentioning

confidence: 99%

What do cancer patients mean when they complain of concentration and memory problems?

Cull

Hay²,

Love³

et al. 1996

Br J Cancer

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Summary Cognitive function items are increasingly included in quality of life measures, and complaints of concentration and memory difficulties are often reported by cancer patients. The aim of this study was to examine the factors influencing patients' level of complaint by comparing subjective reports with objective test performance of a sample of adult lymphoma patients, disease-free and > 6 months after treatment. There was no significant difference between complainers and non-complainers in sociodemographic or clinical characteristics or in their performance on standard neuropsychometric tests of concentration and memory. Those reporting concentration and memory difficulties had significantly higher scores on measures of anxiety, depression and fatigue. This calls into question the validity of including cognitive function items in self-report quality of life measures. Patients who report concentration and memory difficulties should be screened for clinically significant and potentially remediable mood disorder. Objective testing remains the method of choice for assessing higher mental function.

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“…It has been validated in both healthy and ill populations. The authors found the instrument to have good internal consistency, construct validity and convergent validity (37,49) in both Dutch and English. The MFI has been tested on radiotherapy patients, patients with chronic fatigue syndrome, psychology students, medical students, soldiers, and junior physicians (37).…”

Section: Multidimensional Fatigue Inventory (Mfi-20)mentioning

confidence: 99%