Application of the Mild-Condition Phthalimidine Synthesis with Use of 1,2,3-1H-Benzotriazole and 2-Mercaptoethanol as Dual Synthetic Auxiliaries. Effective Synthesis of Phthalimidines Possessing a Variety of Substituents at 2-Position

An efficient O-phthalaldehyde-amine coupling reaction for the synthesis of a bottlebrush polymer under physiological conditions

“…20 Although this reaction has been widely used for the synthesis of small molecules since its first report by Thiele et al in 1909, 21 generally only moderate to low product yields could be achieved. [22][23][24] Recently, Li et al found that the OPA-amine reaction could proceed rapidly and efficiently in aqueous buffer. 25 The reaction proceeded under physiological buffer conditions at room temperature with full conversion and no catalyst was needed.…”