Application of the evaporative light scattering detector to analytical problems in polymer science

Separation of bimodal high density polyethylene using multidimensional high temperature liquid chromatography

“…Furthermore, Fig. 21b indicates that IR detection gives more information on the flanks of low and high molar mass, as there are no volatility issues and no exponential dependency of the detector response as is the case when using ELSD [79,97].…”

“…Although the effect of solvent gradient has been widely eliminated in HT 2D-LC (due to the quasi isocratic conditions in SEC), the parameters of the polymer itself still influence the aerosol formation. Thus, well crystallizable fractions may be over emphasized, while low molar mass components are, due to their volatility, not detectable at all as these rather evaporate in the nebulizer [75,79,97]. IR detection has been widely used to monitor the concentration of eluting fractions as well as their comonomer content K.N.…”

“…While the ELSD remains the sole option for one-dimensional HPLC, its signal is in a complex manner influenced by the solvent gradient as well as the molecular parameters of the eluting polymer [96,97], which in the case considered here are primarily the molar mass and comonomer content. Although the effect of solvent gradient has been widely eliminated in HT 2D-LC (due to the quasi isocratic conditions in SEC), the parameters of the polymer itself still influence the aerosol formation.…”

Characterization of sodium carboxymethyl cellulose by comprehensive two-dimensional liquid chromatography

“…While in the previous SEC manuscript a RI-detector was used, an ELSD was applied in the present investigation. The response of the ELSD is known to depend on a variety of parameters, and might be even non-linear in concentration (Arndt, Macko, & Brüll, 2013). In addition it can depend on molar mass and composition.…”

The effect of drug and EUDRAGIT® S 100 miscibility in solid dispersions on the drug and polymer dissolution rate

“…The effective diffusion range was calculated to be 2-5 nm according to typical   of 5-50 ms, which is significantly smaller than the T 1 of 5-50 s. Hence, the miscibility on the smaller scale of 2-5 nm is evaluated by 1 H-T  measurements compared with the scale of approximately 20-50 nm by 1 H-T  . 34,35,37 In this experiment, 13 C detected-1 H-T  measurements using CP was performed that gives the 1 H-T  of each 13 C peaks. Table 1a shows the 1 H-T  of the DPH/S100 SPD 75 %.…”