Application of the Eosinophilic Esophagitis Histology Scoring System Grade Scores in Patients at British Columbia Children’s Hospital

Cruz, J. Valle; Irvine, Michael A.; Avinashi, Vishal; Chan, Edmond S.; Soller, Lianne

doi:10.1080/15513815.2022.2028950

Cited by 7 publications

(1 citation statement)

References 21 publications

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“…From a demographic perspective, our cohort predominantly comprised males, consistent with previous literature that has identified a male preponderance in EoE [12]. The age range of our study participants, spanning from 2 to 18 years, highlights the broad spectrum of pediatric ages at which EoE can manifest.…”

Section: Discussionsupporting

confidence: 81%

The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis

Jevtić,

Ristić,

Pavlović

et al. 2023

Diagnostics

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Background: Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease with rising incidence. While proton pump inhibitors (PPIs) are the first-line treatment, a significant proportion of patients do not respond. This study aimed to determine if the EoE Histology Scoring System (EoEHSS) can predict PPI responsiveness. Methods: A cross-sectional study was conducted on 89 pediatric patients diagnosed with EoE between 2016 and 2022. Patients were categorized into PPI responders (PPIREoE) and non-responders (PPINREoE) based on post-treatment biopsies. EoEHSS values from biopsies of the esophagus (distal, middle, and proximal segments) were compared between the two groups. Results: No significant differences in EoEHSS scores were observed for the distal and proximal esophagus between the groups. However, the middle esophagus showed a significantly higher EoEHSS grade score in the PPINREoE group, indicating a more pronounced disease severity. Specific histological features, particularly eosinophilic abscesses and surface layering of the middle segment of the esophagus, were significantly different between the groups. Conclusions: Performing a biopsy of each esophageal segment, particularly the middle, is crucial for diagnostic precision and predicting PPI responsiveness. The EoEHSS can serve as a valuable tool in predicting therapy response, emphasizing the need for personalized therapeutic approaches in EoE management.

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Section: Discussionsupporting

confidence: 81%