Application of the combination index integrated with confidence intervals to study the toxicological interactions of antibiotics and pesticides in Vibrio qinghaiensis sp.-Q67

Liu, Ling; Liu, Shu-Shen; Yu, Mo; Chen, Fu

doi:10.1016/j.etap.2014.12.013

Cited by 34 publications

(13 citation statements)

References 53 publications

(50 reference statements)

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“…While ED and EL mixtures presented additive action at 30% and 50% effect levels, and presented synergistic action at 80% effect level except for the additive action of the E3 mixture. Theoretically, CTC [40] was the deformation expression of CA, and the reciprocal form of the combination index [41]. Therefore, CTC only reflected the judgment result of CA on toxic interaction [42].…”

Section: Enantiomer Mixture Crc and Ctcmentioning

confidence: 99%

New Insight Regarding the Relationship Between Enantioselective Toxicity Difference and Enantiomeric Toxicity Interaction from Chiral Ionic Liquids

Zhou

et al. 2019

IJMS

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Chirality is an important property of molecules. The study of biological activity and toxicity of chiral molecules has important theoretical and practical significance for toxicology, pharmacology, and environmental science. The toxicological significance of chiral ionic liquids (ILs) has not been well revealed. In the present study, the enantiomeric joint toxicities of four pairs of chiral ILs 1-alkyl-3-methylimidazolium lactate to Allivibrio fischeri were systematically investigated by using a comprehensive approach including the co-toxicity coefficient (CTC) integrated with confidence interval (CI) method (CTCICI), concentration-response curve (CRC), and isobole analysis. The direct equipartition ray (EquRay) design was used to design five binary mixtures of enantiomers according to molar ratios of 1:5, 2:4, 3:3, 4:2, and 5:1. The toxicities of chiral ILs and their mixtures were determined using the microplate toxicity analysis (MTA) method. Concentration addition (CA) and independent action (IA) were used as the additive reference models to construct the predicted CRC and isobole of mixtures. On the whole, there was an enantioselective toxicity difference between [BMIM]D-Lac and [BMIM]L-Lac, and [HMIM]D-Lac and [HMIM]L-Lac, while no enantioselective toxicity difference was observed for [EMIM]D-Lac and [EMIM]L-Lac, and [OMIM]D-Lac and [OMIM]L-Lac. Thereinto, the enantiomer mixtures of [BMIM]D-Lac and [BMIM]L-Lac, and [HMIM]D-Lac and [HMIM]L-Lac presented antagonistic action, and the enantiomer mixtures of [EMIM]D-Lac and [EMIM]L-Lac, and [OMIM]D-Lac and [OMIM]L-Lac overall presented additive action. Moreover, the greatest antagonistic toxicity interaction occurred at the equimolar ratio of enantiomers. Based on these results, we proposed two hypotheses, (1) chiral molecules with enantioselective toxicity difference tended to produce toxicity interactions, (2) the highest or lowest toxicity was usually at the equimolar ratio and its adjacent ratio for the enantiomer mixture. These hypotheses will need to be further validated by other enantiomer mixtures.

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Section: Enantiomer Mixture Crc and Ctcmentioning

confidence: 99%

New Insight Regarding the Relationship Between Enantioselective Toxicity Difference and Enantiomeric Toxicity Interaction from Chiral Ionic Liquids

Zhou

et al. 2019

IJMS

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“…Figure 1 presents the time-dependent hormesis of POL on Q67. Fan et al [25] and Liu et al [40] found that some antibiotics did not have hormetic CRCs on Q67.…”

Section: Discussionmentioning

confidence: 99%

The weak magnetic field (WMF) enhances the stimulation of polymyxin B sulfate (POL) on Vibrio qinghaiensis sp.-Q67

Wang

et al. 2020

Environ Sci Eur

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Background: The weak magnetic field (WMF) can enhance the ability to remove target pollutants in wastewater, which drives us to consider whether WMF could give rise to the hormesis or not. In our previous study, it was found that polymyxin B sulfate (POL) can induce weak hormesis on Vibrio qinghaiensis sp.-Q67 (Q67). To this end, we set up four different WMF treatments during Q67 culture and POL exposure process, having no WMF in all cases (NW), adding WMF all the time (AW), exerting WMF only during the bacterial culture (BW), and exerting WMF only in POL exposure period (EW). Results: It was shown that the concentration-response curves (CRCs) of POL in four WMF treatments at the exposure times of 6, 9, and 12 h are non-monotonic hormetic curves where the maximum stimulative effects (E min) of POL in BW and EW are obviously larger than those in AW and NW. The maximum E min is 26.8% occurring in EW and 20.7% in BW at 6 h, while the max E min is 14.6% in NW at 9 h, it means that stimulations of POL in BW and EW are earlier and stronger than those in NW. These findings first indicated that WMF can enhance the hormesis of POL. Conclusions: This study showed that WMF as a key factor may influence the maximum stimulation effect of hormesis. The characteristic of biphasic (hormetic effect) challenges the traditional classical threshold model that is close to chemical risk assessment. But the mechanism of hormesis even now is inconclusive. WMF as a novelty and neglected factor has the potential to support the further development of hormesis mechanism.

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“…EquRay was employed to design the basic concentration compositions of five binary mixture rays43. The mixture ratios ( p i,j )44, the ratio of the concentration of the j th component in the i th ray to the total concentration of the ray, of various components in 30 mixture rays and the concentrations of stocks were listed in Table 3.…”

Section: Methodsmentioning

confidence: 99%

Using Delaunay triangulation and Voronoi tessellation to predict the toxicities of binary mixtures containing hormetic compound

Liu

Zheng

et al. 2017

Sci Rep

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Concentration addition (CA) was proposed as a reasonable default approach for the ecological risk assessment of chemical mixtures. However, CA cannot predict the toxicity of mixture at some effect zones if not all components have definite effective concentrations at the given effect, such as some compounds induce hormesis. In this paper, we developed a new method for the toxicity prediction of various types of binary mixtures, an interpolation method based on the Delaunay triangulation (DT) and Voronoi tessellation (VT) as well as the training set of direct equipartition ray design (EquRay) mixtures, simply IDVequ. At first, the EquRay was employed to design the basic concentration compositions of five binary mixture rays. The toxic effects of single components and mixture rays at different times and various concentrations were determined by the time-dependent microplate toxicity analysis. Secondly, the concentration-toxicity data of the pure components and various mixture rays were acted as a training set. The DT triangles and VT polygons were constructed by various vertices of concentrations in the training set. The toxicities of unknown mixtures were predicted by the linear interpolation and natural neighbor interpolation of vertices. The IDVequ successfully predicted the toxicities of various types of binary mixtures.

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Application of the combination index integrated with confidence intervals to study the toxicological interactions of antibiotics and pesticides in Vibrio qinghaiensis sp.-Q67

Cited by 34 publications

References 53 publications

New Insight Regarding the Relationship Between Enantioselective Toxicity Difference and Enantiomeric Toxicity Interaction from Chiral Ionic Liquids

New Insight Regarding the Relationship Between Enantioselective Toxicity Difference and Enantiomeric Toxicity Interaction from Chiral Ionic Liquids

The weak magnetic field (WMF) enhances the stimulation of polymyxin B sulfate (POL) on Vibrio qinghaiensis sp.-Q67

Using Delaunay triangulation and Voronoi tessellation to predict the toxicities of binary mixtures containing hormetic compound

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