Abstract:A simple, sensitive, and precise spectrophotometric method has been developed for the quantification of esomeprazole as pure and in its dosage form (injection). The developed method is based on the diazo-coupling reaction of esomeprazole with a diazotized p-nitroaniline to produce a yellow azo dye soluble in an aqueous medium and gave a maximum absorption at 440 nm. Then using cloud point extraction method by adding Triton X-114 to azo dye solution and heating in water-bath at 50 0 C for 25 minutes. The cloudy… Show more
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