Application of the chronic constriction injury of the partial sciatic nerve model to assess acupuncture analgesia

Zhi, Mujun; Liu, Kun; Zheng, Zhou-Li; He, Xingxing; Li, Tie; Sun, Guang Ping; Zhang, Meng; Wang, Fuchun; Gao, Xin-Yan; Zhu, Bing

doi:10.2147/jpr.s139324

Cited by 10 publications

(8 citation statements)

References 27 publications

(38 reference statements)

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“…The intensities of EA used in this study were identified as the thresholds of the A- and C-fiber activation. The ipsilateral biceps femoris muscle reflex was evoked by electrical stimulation of the A- and C-fibers within the receptive field of the sural nerve ( Guirimand et al, 1994 ; Zhi et al, 2017 ). Specifically, EMG responses were recorded via a pair of needles inserted into the biceps femoris muscle.…”

Section: Methodsmentioning

confidence: 99%

Electroacupuncture-Induced Muscular Inflammatory Pain Relief Was Associated With Activation of Low-Threshold Mechanoreceptor Neurons and Inhibition of Wide Dynamic Range Neurons in Spinal Dorsal Horn

et al. 2021

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Acupuncture is an effective alternative therapy for pain management. Evidence suggests that acupuncture relieves pain by exciting somatic afferent nerve fibers. However, the mechanism underlying the interaction between neurons in different layers of the spinal dorsal horn induced by electroacupuncture (EA) remains unclear. The aim of this study was to explore the mechanism of EA relieving inflammatory muscle pain, which was associated with activation of the spontaneous firing of low-threshold mechanoreceptor (LTM) neurons and inhibition of wide dynamic range (WDR) neuronal activities in the spinal dorsal horn of rats. Inflammatory muscle pain was induced by injecting complete Freund’s adjuvant into the right biceps femoris muscle. EA with intensity of threshold of A fibers (Ta) in Liangqiu (ST34) muscle considerably inhibited the abnormal spontaneous activities of electromyography (EMG) due to muscle inflammation. While EA with intensity of C-fiber threshold (Tc) increased the abnormal activities of EMG. EA with Ta also ameliorated the imbalance of weight-bearing behavior. A microelectrode array with 750-μm depth covering 32 channels was used to record the neuronal activities of WDR and LTM in different layers of the spinal dorsal horn. The spontaneous firing of LTM neurons was enhanced by EA-Ta, while the spontaneous firing of WDR neurons was inhibited. Moreover, EA-Ta led to a significant inverse correlation between changes in the frequency of WDR and LTM neurons (r = −0.64, p < 0.05). In conclusion, the results indicated that EA could alleviate inflammatory muscle pain, which was associated with facilitation of the spontaneous firing of LTM neurons and inhibition of WDR neuronal activities. This provides a promising evidence that EA-Ta could be applied to relieve muscular inflammatory pain in clinical practice.

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Section: Methodsmentioning

confidence: 99%

Electroacupuncture-Induced Muscular Inflammatory Pain Relief Was Associated With Activation of Low-Threshold Mechanoreceptor Neurons and Inhibition of Wide Dynamic Range Neurons in Spinal Dorsal Horn

et al. 2021

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“…Needling beyond and not at the site of compression is common in practice as most points being needled for sciatica are distal or proximal to sites of potential nerve compression. This approach has shown to inhibit nociception in CCI models of neuropathic pain lending support to the common acupuncture practices for sciatica [ 13 ]. For sciatica, placement of needles along the dermatomes, myotomes and spinal segments related to the sciatic nerve seems to be effective [ 52 ].…”

Section: Discussionmentioning

confidence: 96%

“…Due to their position, A1Rs have been shown to modulate Aβ fiber activity and reduce tactile allodynia under conditions of NP [ 20 ]. Adenosine also acts on A1Rs of afferent terminals to inhibit substance P (SP), calcitonin gene related peptide (CGRP) and excitatory neurotransmitter release [ 100 ] making it useful for NP by counteracting increased neuropeptide expression that occurs following nerve injury [ 13 ]. Evidenced demonstrates that ectonucleotidases reside within the epineurium of peripheral nerves, the membrane of DRG neurons and their axon terminals in lamina Ⅱ, which hydrolyze nucleotides into adenosine [ 95 , 96 , 101 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, NP is often studied using chronic constriction injury (CCI) of the sciatic nerve in animal models. Interestingly, CCI models imitate the compression-induced nerve injury seen in sciatica and related NP conditions in humans [ 13 ]. Since sciatica can involve nerve root compression and symptoms consistent with NP, a mechanism-based-approach is called for to provide optimal management strategies.…”

Section: Introductionmentioning

confidence: 99%

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Needling Interventions for Sciatica: Choosing Methods Based on Neuropathic Pain Mechanisms—A Scoping Review

Perreault

Fernández‐de‐las‐Peñas

Cummings³

et al. 2021

JCM

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Sciatica is a condition often accompanied by neuropathic pain (NP). Acupuncture and dry needling are common treatments for pain, and the current literature supports acupuncture as an effective treatment for sciatica. However, it is unknown if the mechanisms of NP are considered in the delivery of needling interventions for sciatica. Our objective was to assess the efficacy and the effectiveness of needling therapies, to identify common needling practices and to investigate if NP mechanisms are considered in the treatment of sciatica. A scoping review of the literature on needling interventions for sciatica and a review of the literature on mechanisms related to NP and needling interventions were performed. Electronic literature searches were conducted on PubMed, MEDLINE, CINAHL and Cochrane Database of Systematic Reviews from inception to August, 2020 to identify relevant papers. Reference lists of included papers were also manually screened and a related-articles search through PubMed was performed on all included articles. Mapping of the results included description of included studies, summary of results, and identification of gaps in the existing literature. Ten articles were included. All studies used acupuncture for the treatment of sciatica, no studies on dry needling were identified. Current evidence supports the efficacy and effectiveness of acupuncture for sciatica, however, no studies considered underlying NP mechanisms in the acupuncture approach for sciatica and the rationale for using acupuncture was inconsistent among trials. This review reveals that neuropathic pain mechanisms are not routinely considered in needling approaches for patients with sciatica. Studies showed acupuncture to be an effective treatment for sciatic pain, however, further research is warranted to explore if needling interventions for sciatica and NP would be more effective if NP mechanisms are considered.

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“…Therefore, the present study was undertaken to examine the interaction of analgesic and anxiolytic effects of crocin with α1-and α2-adrenoceptors of ACC in chronic constriction injury (CCI) model of the sciatic nerve. It is shown that CCI model is an animal model of neuropathic pain, which is similar to human peripheral nerve injury and its sign and symptoms [28].…”

Section: Introductionmentioning

confidence: 99%

Crocin suppressed cold allodynia and anxiety through ?2-adrenoceptors in the anterior cingulate cortex following chronic constriction injury of sciatic nerve in rats

Zohrehvand¹,

Kazemi²,

Mirasheh³

et al. 2020

JRP

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Application of the chronic constriction injury of the partial sciatic nerve model to assess acupuncture analgesia

Cited by 10 publications

References 27 publications

Electroacupuncture-Induced Muscular Inflammatory Pain Relief Was Associated With Activation of Low-Threshold Mechanoreceptor Neurons and Inhibition of Wide Dynamic Range Neurons in Spinal Dorsal Horn

Electroacupuncture-Induced Muscular Inflammatory Pain Relief Was Associated With Activation of Low-Threshold Mechanoreceptor Neurons and Inhibition of Wide Dynamic Range Neurons in Spinal Dorsal Horn

Needling Interventions for Sciatica: Choosing Methods Based on Neuropathic Pain Mechanisms—A Scoping Review

Crocin suppressed cold allodynia and anxiety through ?2-adrenoceptors in the anterior cingulate cortex following chronic constriction injury of sciatic nerve in rats

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