Application of Tc-99m-tetrofosmin as a tumor imaging agent: Comparison with Tl-201

Arbab, Ali S.; Koizumi, Kiyoshi; Arai, Takao; Toyama, Keiji; Araki, Tsutomu

doi:10.1007/bf03165405

Cited by 25 publications

(14 citation statements)

References 2 publications

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“…The animals were restrained using proper retainer for mice and were injected in the tail vein with 1 mCi of 99mTc‐tetrofosmin. 99mTc‐tetrofosmin accumulates in larger amounts in tumor cells due to increased mitochondrial activity .…”

Section: Methodsmentioning

confidence: 99%

Melatonin decreases breast cancer metastasis by modulating Rho‐associated kinase protein‐1 expression

Borin

Arbab

Gelaleti

et al. 2015

Journal of Pineal Research

125

107

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The occurrence of metastasis, an important breast cancer prognostic factor, depends on cell migration/invasion mechanisms, which can be controlled by regulatory and effector molecules such as Rho-associated kinase protein (ROCK-1). Increased expression of this protein promotes tumor growth and metastasis, which can be restricted by ROCK-1 inhibitors. Melatonin has shown oncostatic, antimetastatic, and anti-angiogenic effects and can modulate ROCK-1 expression. Metastatic and nonmetastatic breast cancer cell lines were treated with melatonin as well as with specific ROCK-1 inhibitor (Y27632). Cell viability, cell migration/invasion, and ROCK-1 gene expression and protein expression were determined in vitro. In vivo lung metastasis study was performed using female athymic nude mice treated with either melatonin or Y27832 for 2 and 5 wk. The metastases were evaluated by X-ray computed tomography and single photon emission computed tomography (SPECT) and by immunohistochemistry for ROCK-1 and cytokeratin proteins. Melatonin and Y27632 treatments reduced cell viability and invasion/migration of both cell lines and decreased ROCK-1 gene expression in metastatic cells and protein expression in nonmetastatic cell line. The numbers of ‘hot’ spots (lung metastasis) identified by SPECT images were significantly lower in treated groups. ROCK-1 protein expression also was decreased in metastatic foci of treated groups. Melatonin has shown to be effective in controlling metastatic breast cancer in vitro and in vivo, not only via inhibition of the proliferation of tumor cells but also through direct antagonism of metastatic mechanism of cells rendered by ROCK-1 inhibition. When Y27632 was used, the effects were similar to those found with melatonin treatment.

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Section: Methodsmentioning

confidence: 99%

Melatonin decreases breast cancer metastasis by modulating Rho‐associated kinase protein‐1 expression

Borin

Arbab

Gelaleti

et al. 2015

Journal of Pineal Research

125

107

View full text Add to dashboard Cite

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“…It was reported that heart/lung ratio was higer than 2 and heart/liver ratio higher than 0.5 [5] . Therefore 99m Tc-TF uptake of lung neoplasmas may exhibite a higher T/N ratio and be affected lightly by liver.…”

Section: Discussionmentioning

confidence: 99%

The clinical usefulness of 99mTc-Tetrofosmin scintigraphy in the diagnosis of lung neoplasmas and mediastinal lymphoid node involvement

Huang

Zhao

Zhang

2008

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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In order to investigate the clinical significance of (99m)Tc-Tetrofosmin (TF) scintigraphy in the evaluation of lung cancer and mediastinal lymphoid node involvement, 33 patients with pulmonary neoplasmas were subjected to both (99m)Tc-TF scintigraphies and CT scans in one week before their operations or puncturations. All the images were judged visually and the emission images were analyzed with semi-quantitative methods in addition. The results of each group were compared. There was marked difference in target/non-target (T/N) ratio between the lung cancer group and the benign lesion group (P<0.001). Moreover, in the lung cancer group, T/N ratio in tomographies was significantly higher than that in planar images (P<0.01). The sensitivity and accuracy of semi-quantitative analysis in (99m)Tc-TF SPECT were significantly higher than those of CT in the diagnosis of pulmonary neoplasmas (P<0.05 and P<0.01 respectively), so was the sensitivity of (99m)Tc-TF SPECT vs CT in the diagnosis of mediastinal lymphoid node metastasis (P<0.05). It was also found that epidermoid squamous cell carcinomas and adenocarcinomas had a higher T/N ratio than in small cell carcinomas (P<0.05), and 2 h washout rate (WR) of adenocarcinomas was higher than that of epidermoid squamous cell carcinomas (P<0.05). In conclusion, (99m)Tc-TF scintigraphy showed a favorable diagnostic accuracy in appraising lung cancers and mediastinal lymph node metastases. Furthermore semi-quantitative technology can improve the accuracy, and is potential to offer some information about histological type of the cancer tissue. Therefore, (99m)Tc-TF scintigraphy will be a useful tool in the diagnosis and staging of lung cancer.

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Some authors reported that not only the primary lesion but also its lymph node metastases were delineated. Schillaci et al 5 reported 99 mTc-tetrofosmin accumulation in a patient with lung cancer (adenocarcinoma) and its brain and mediastinal lymph node metastases.…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17][18][19][20] In some cases, not only the primary lesion but also its lymph node metastases were delineated in patients with lung cancer, thyroid cancer and breast cancer, but there is no report on the visualization of bone metastases from breast cancer. We present a case of high tracer uptake in bone metastasis from breast cancer.…”

Section: Introductionmentioning

confidence: 99%

99mTc-tetrofosmin uptake in bone metastases from breast cancer

Takayama

Kinuya

Sugiyama³

et al. 1998

Ann Nucl Med

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99mTc-tetrofosmin myocardial imaging was performed in a 62-year-old woman who had undergone standard radical mastectomy for right breast cancer 6 years ago. Although the result was negative for the ischemic heart disease, it showed abnormal accumulation corresponding to the bone metastases in the spine. We believe that 99mTc-tetrofosmin imaging is helpful in detecting bone metastases from breast cancer.

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Application of Tc-99m-tetrofosmin as a tumor imaging agent: Comparison with Tl-201

Cited by 25 publications

References 2 publications

Melatonin decreases breast cancer metastasis by modulating Rho‐associated kinase protein‐1 expression

Melatonin decreases breast cancer metastasis by modulating Rho‐associated kinase protein‐1 expression

The clinical usefulness of 99mTc-Tetrofosmin scintigraphy in the diagnosis of lung neoplasmas and mediastinal lymphoid node involvement

99mTc-tetrofosmin uptake in bone metastases from breast cancer

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