Application of Tapping-Mode Scanning Probe Electrospray Ionization to Mass Spectrometry Imaging of Additives in Polymer Films

Shimazu, Ryo; Yamoto, Yoshinari; Kosaka, Tomoya; Kawasaki, Hideya; Arakawa, Ryuichi

doi:10.5702/massspectrometry.s0050

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…e timing of the liquid bridge formation and the ESI are separated by the probe oscillation. Tapping-mode scanning probe electrospray ionization mass spectrometry imaging (t-SPESI-MSI) of tissue sections of mouse brain, 11) mouse pancreatic cancer tissue, 12) and a polymer lm 13) has been reported. e spatial resolution of t-SPESI-MSI depends on the size of the liquid bridge.…”

Section: Introductionmentioning

confidence: 99%

Reduced Sampling Size with Nanopipette for Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging

et al. 2016

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Mass spectrometry imaging (MSI) with ambient sampling and ionization can rapidly and easily capture the distribution of chemical components in a solid sample. Because the spatial resolution of MSI is limited by the size of the sampling area, reducing sampling size is an important goal for high resolution MSI. Here, we report the rst use of a nanopipette for sampling and ionization by tapping-mode scanning probe electrospray ionization (t-SPESI). e spot size of the sampling area of a dye molecular lm on a glass substrate was decreased to 6 µm on average by using a nanopipette. On the other hand, ionization e ciency increased with decreasing solvent ow rate. Our results indicate the compatibility between a reduced sampling area and the ionization e ciency using a nanopipette. MSI of micropatterns of ink on a glass and a polymer substrate were also demonstrated.

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Section: Introductionmentioning

confidence: 99%

Reduced Sampling Size with Nanopipette for Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging

et al. 2016

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Development of Scanning Probe Electrospray Ionization Mass Spectrometry and Label Free Mass Imaging of Biological Tissue Section

Otsuka

2016

Journal of The Surface Science Society of Japan

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Understanding the spatial distribution of chemical components inside materials is essential to make advances in science and technology. Scanning probe electrospray ionization mass spectrometry (SPESI-MS) is an analytical technique to realize the ambient sampling and ionization. The fusion of the electrospray ionization technique in mass spectrometry and the technique used in scanning probe microscopy has given a birth to a new analytical method. The demonstration of a label-free mass imaging of biological tissue sections showed the possibility of bio-marker detection and or discovery by SPESI-MS.

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Visualization of Sampling and Ionization Processes in Scanning Probe Electrospray Ionization Mass Spectrometry

et al. 2019

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Ambient sampling and ionization techniques based on direct liquid extraction and electrospray ionization are of great value for rapid analysis and mass spectrometry imaging. Scanning probe electrospray ionization (SPESI) enables the sampling and ionization of analyte molecules in a solid material using a liquid bridge and electrospray, respectively, from a single capillary probe. To further improve SPESI, it is essential to understand the dynamic behavior of nanoliter volumes of liquids during sampling and ionization. In this study, the dynamic formation and breakage of the liquid bridge and the subsequent electrospray ionization were investigated by measuring the displacement of the capillary probe using a new optical technique. Measurements revealed that both the time from the formation of the liquid bridge to its breakage and the time from the breakage of the liquid bridge to the detection of analyte ions were correlated with the physical properties of the solvent. It was also found that both of these times were positively correlated with the flow rate. These results will not only lead to the improvement of sampling and ionization efficiencies but also afford a greater understanding of the physicochemical properties of charged nanoliter volumes of liquids.

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Application of Tapping-Mode Scanning Probe Electrospray Ionization to Mass Spectrometry Imaging of Additives in Polymer Films

Cited by 3 publications

References 19 publications

Reduced Sampling Size with Nanopipette for Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging

Reduced Sampling Size with Nanopipette for Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging

Development of Scanning Probe Electrospray Ionization Mass Spectrometry and Label Free Mass Imaging of Biological Tissue Section

Visualization of Sampling and Ionization Processes in Scanning Probe Electrospray Ionization Mass Spectrometry

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